Results 111 to 120 of about 168,919,123 (296)

Issues for the long-term management of Social Business Documents

International Journal of Information Systems and Project Management, 2016
Social business documents are currently one of the fastest growing content types within organizations. As carriers of important business information they require systematic management to ensure their content is available, accurate and protected over the ...
Verena Hausmann, Susan Williams, , ,
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Types of licensed child care in Oregon. Russian

, 2016
"LIC-311ru 4/5/2016."Includes list of situations when child care providers are not required to be licensed.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Opportunities, challenges, and strategies for using ChatGPT in higher education: A literature review

Journal of Digital Educational Technology
While there is a growing body of research on chat generative pre-trained transformer (ChatGPT) in education, there appears to be little research that provides a comprehensive review of challenges, opportunities, and strategies for the effective ...
Sarin Sok, Kimkong Heng
semanticscholar   +1 more source

Types of licensed child care in Oregon. Vietnamese

, 2016
"LIC-311vn 4/5/2016."Includes list of situations when child care providers are not required to be licensed.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Developing a manually annotated clinical document corpus to identify phenotypic information for inflammatory bowel disease

BMC Bioinformatics, 2009
Background Natural Language Processing (NLP) systems can be used for specific Information Extraction (IE) tasks such as extracting phenotypic data from the electronic medical record (EMR).
Jones Makoto, Shen Shuying, South Brett R, Garvin Jennifer, Samore Matthew H, Chapman Wendy W, Gundlapalli Adi V   +6 more
doaj   +1 more source

Types of licensed child care in Oregon. Chinese

, 2016
"LIC-311ch 4/5/2016."Includes list of situations when child care providers are not required to be licensed.This archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program.

core