Results 31 to 40 of about 3,977 (192)

Conservation of the OmpC Porin Among Typhoidal and Non-Typhoidal Salmonella Serovars

Frontiers in Immunology, 2020
Salmonella enterica infections remain a challenging health issue, causing significant morbidity and mortality worldwide. Current vaccines against typhoid fever display moderate efficacy whilst no licensed vaccines are available for paratyphoid fever or ...
Nuriban Valero-Pacheco, Nuriban Valero-Pacheco, Nuriban Valero-Pacheco, Joshua Blight, Gustavo Aldapa-Vega, Gustavo Aldapa-Vega, Phillip Kemlo, Marisol Pérez-Toledo, Marisol Pérez-Toledo, Isabel Wong-Baeza, Ayako Kurioka, Christian Perez-Shibayama, Cristina Gil-Cruz, Luvia E. Sánchez-Torres, Rodolfo Pastelin-Palacios, Armando Isibasi, Arturo Reyes-Sandoval, Paul Klenerman, Constantino López-Macías, Constantino López-Macías, Constantino López-Macías   +20 more
doaj   +1 more source

Characterization and protective efficacy of a sptP mutant of Salmonella Paratyphi A

Immunity, Inflammation and Disease, Volume 8, Issue 4, Page 774-781, December 2020., 2020
Salmonella Paratyphi A lacking sptP is attenuated, immunogenic, and protective in mice. The sptP mutant SPA017ΔsptP has the potential of being a live‐attenuated vaccine candidate. Abstract Background Salmonella Paratyphi A causes paratyphoid A, a severe systemic disease of people and remains a major public health problem in many parts of the world.
Pengtao Pan, Fanyu Zou, Chuanshan He, Qunli He, Junlei Yin   +4 more
wiley   +1 more source

Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes reveal differentially expressed proteins linked to the cell surface and pathogenicity [PDF]

, 2019
Background: Salmonella enterica subsp. enterica contains more than 2,600 serovars of which four are of major medical relevance for humans. While the typhoidal serovars (Typhi and Paratyphi A) are human-restricted and cause enteric fever, non-typhoidal ...
Barbé, Barbara, Deborggraeve, Stijn, Gevaert, Kris, Jacobs, Jan, Saleh, Sara, Staes, An, Timmerman, Evy, Van Puyvelde, Sandra   +7 more
core   +2 more sources

Human Salmonella Typhi exposure generates differential multifunctional cross‐reactive T‐cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella

Clinical &Translational Immunology, Volume 9, Issue 9, 2020., 2020
Vaccines are lacking against several of the major causes of invasive Salmonella disease, such as invasive nontyphoidal Salmonella and S. Paratyphi A. These studies demonstrate that T memory cell effector responses generated after human wt Salmonella Typhi mucosal infection are multifunctional and cross‐reactive against S. Paratyphi A, S.
Rekha R Rapaka, Rezwanul Wahid, Stephanie Fresnay, Jayaum S Booth, Thomas C Darton, Claire Jones, Claire S Waddington, Myron M Levine, Andrew J Pollard, Marcelo B Sztein   +9 more
wiley   +1 more source

Extensively Drug‐Resistant (XDR) Typhoid: Evolution, Prevention, and Its Management

BioMed Research International, Volume 2020, Issue 1, 2020., 2020
Typhoid fever is the result of a human host‐restricted Salmonella enteric serotype typhi infection that causes enteric fever. Around 21 million people contract typhoid annually, with Pakistan’s inhabitants at most risk amongst Asian countries where typhoid remains prevalent.
Javed Akram, Arsalan Shamim Khan, Hassan Ahmed Khan, Syed Amir Gilani, Shehla Javed Akram, Fridoon Jawad Ahmad, Riffat Mehboob, Oguz R. Sipahi   +7 more
wiley   +1 more source

Predicting the Impact of Vaccination on the Transmission Dynamics of Typhoid in South Asia: A Mathematical Modeling Study [PDF]

, 2014
Background: Modeling of the transmission dynamics of typhoid allows for an evaluation of the potential direct and indirect effects of vaccination; however, relevant typhoid models rooted in data have rarely been deployed.
Baker, Stephen, Balaji, Veeraraghavan, Bowles, Cayley C., Farrar, Jeremy J., Grenfell, Bryan T., Kang, Gagandeep, Pitzer, Virginia E.   +6 more
core   +4 more sources

Enteric fever among children: 50 cases in a French tertiary care centre. [PDF]

, 2018
Background: Enteric fever in France is primarily travel-associated. Characteristics of paediatric cases are scarce and information from field studies in endemic countries might not be generalizable to non-endemic countries. Methods: In this retrospective
Basmaci, R, Bonacorsi, S, Faye, A, Gaschignard, J, Lauzanne, AD, Lemaitre, C, Mariani, P, Morin, L, Pommelet, V, Tourdjman, M   +9 more
core   +1 more source

The effects of vaccination and immunity on bacterial infection dynamics in vivo. [PDF]

, 2014
Salmonella enterica infections are a significant global health issue, and development of vaccines against these bacteria requires an improved understanding of how vaccination affects the growth and spread of the bacteria within the host. We have combined
A Vazquez-Torres, AC McGregor, AJ Grant, AJ Grant, AN Layton, Andrew J. Grant, C Coward, CA Guzman, CE Hormaeche, Chris Coward, CM Parry, CM Rosenberger, Denise M. Monack, Duncan J. Maskell, EK Mulholland, EL Hohmann, ER Moxon, FM Collins, FM Collins, FM Collins, GB Mackaness, GG Meynell, GG Meynell, H Smith, H Uppington, I Hauteforte, J Thatte, JA Crump, JA Harrison, M Sheppard, MA Gordon, MB Sztein, MK Siggins, MM Levine, N Ménager, O Restif, Olivier Restif, P Kaiser, P Mastroeni, P Mastroeni, P Mastroeni, P Mastroeni, P Mastroeni, P Mastroeni, P Mastroeni, P Mastroeni, P van Damme, Pietro Mastroeni, Richard Dybowski, RV Blanden, S Dorai-Raj, S Helaine, S Helaine, S Helaine, S Marcus, SC Szu, SK Hoiseth, SP Cobbold, SP Cobbold, TK Eisenstein, WH Benjamin Jr   +60 more
core   +8 more sources

Homologous and heterologous re-challenge with Salmonella Typhi and Salmonella Paratyphi A in a randomised controlled human infection model.

PLoS Neglected Tropical Diseases, 2020
Enteric fever is a systemic infection caused by Salmonella Typhi or Paratyphi A. In many endemic areas, these serovars co-circulate and can cause multiple infection-episodes in childhood.
Malick M Gibani, Celina Jin, Sonu Shrestha, Maria Moore, Lily Norman, Merryn Voysey, Elizabeth Jones, Luke Blackwell, Helena Thomaides-Brears, Jennifer Hill, Christoph J Blohmke, Hazel C Dobinson, Philip Baker, Claire Jones, Danielle Campbell, Yama F Mujadidi, Emma Plested, Lorena Preciado-Llanes, Giorgio Napolitani, Alison Simmons, Melita A Gordon, Brian Angus, Thomas C Darton, Vincenzo Cerundulo, Andrew J Pollard   +24 more
doaj   +1 more source

THE STANDARDIZATION OF TYPHOID-PARATYPHOID VACCINE

American Journal of Public Health, 1925
Data from other workers have been quoted which show that the baneful effect upon infants of milk of high prepasteurized bacterial content has been recognized and elucidated. Data are given covering observations in Baltimore of three years' duration, in the first two of which this hypothesis seems to be supported while in the last year it is not ...
openaire   +3 more sources