Results 11 to 20 of about 2,705 (182)

A forecast of typhoid conjugate vaccine introduction and demand in typhoid endemic low- and middle-income countries to support vaccine introduction policy and decisions

Human Vaccines & Immunotherapeutics, 2017
A Typhoid Conjugate Vaccine (TCV) is expected to acquire WHO prequalification soon, which will pave the way for its use in many low- and middle-income countries where typhoid fever is endemic.
Vittal Mogasale, Enusa Ramani, Il Yeon Park, Jung Seok Lee   +3 more
doaj   +4 more sources

Evidence of Extended Thermo-Stability of Typhoid Polysaccharide Conjugate Vaccines [PDF]

Microorganisms, 2021
Typhoid conjugate vaccines (TCV) are effective in preventing enteric fever caused by Salmonella enterica serovar Typhi in Southeast Asia and Africa. To facilitate vaccination with the Vi capsular polysaccharide–tetanus toxoid conjugate vaccine, Typbar ...
Fang Gao, Kay Lockyer, Alastair Logan, Sarah Davis, Barbara Bolgiano, Sjoerd Rijpkema, Gopal Singh, Sai D. Prasad, Samuel Pradeep Dondapati, Gurbaksh Singh Sounkhla   +9 more
doaj   +4 more sources

Early Insights From Clinical Trials of Typhoid Conjugate Vaccine [PDF]

Clinical Infectious Diseases, 2020
Abstract Clinical trials of typhoid conjugate vaccine (TCV) are ongoing in 4 countries. Early data confirm safety, tolerability, and immunogenicity of typhoid conjugate vaccine, and early efficacy results are promising. These data support World Health Organization recommendations and planned country introductions.
Kathleen M. Neuzil, Buddha Basnyat, John D. Clemens, Melita A. Gordon, Priyanka Patel, Andrew J. Pollard, Mila Shakya, Firdausi Qadri   +7 more
openaire   +5 more sources

Typhoid Conjugate Vaccines: Advancing the Research and Public Health Agendas [PDF]

The Journal of Infectious Diseases, 2021
Abstract The disease burden of typhoid fever remains high in endemic areas in Asia and Africa, especially in children. Recent clinical trials conducted by the Typhoid Vaccine Acceleration Consortium show typhoid conjugate vaccine (TCV) to be safe, immunogenic, and efficacious at preventing blood culture-confirmed typhoid fever in African
Birkhold, M, Mwisongo, A, Pollard, AJ, Neuzil, KM   +3 more
openaire   +4 more sources

Typhoid conjugate vaccines: making vaccine history in Africa [PDF]

Expert Review of Vaccines, 2018
The 21 February 2018 was a day in vaccine history as 4-year old Golden Kondowe became the first child in Africa to be enrolled in an individually randomized vaccine efficacy trial of a newly WHO pr...
James E. Meiring, Pratiksha Patel, Priyanka Patel, Melita A. Gordon   +3 more
doaj   +3 more sources

Development of Vi conjugate – a new generation of typhoid vaccine [PDF]

Expert Review of Vaccines, 2013
Typhoid fever remains to be a serious disease burden worldwide with an estimated annual incidence about 20 million. The licensed vaccines showed moderate protections and have multiple deficiencies. Most important of all, none of the licensed typhoid vaccines demonstrated protection for children under 5 years old.
S C Szu
exaly   +4 more sources

Opinion of Parents Regarding Conjugate Typhoid Vaccine

Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College, 2020
Objective : To study the opinion of parents regarding conjugate typhoid vaccine . Method : 400 parents bringing their kids for vaccination were enrolled for the study at the vaccination clinic of The Karachi Adventist Hospital .A cross sectional ...
M.Hanif Memon, Farhan Saeed, Muhammad Iqbal , Muhammad Athar Khan, Erum Saboohi saboohi, fatima Siraj, fatima Siraj   +6 more
doaj   +2 more sources

Toward Control? The Prospects and Challenges of Typhoid Conjugate Vaccine Introduction [PDF]

Clinical Infectious Diseases, 2019
Abstract With a newly World Health Organization (WHO)–prequalified typhoid conjugate vaccine (TCV), Gavi funding for eligible countries, and a WHO policy recommendation for TCV use, now is the time for countries to introduce TCVs as part of an integrated typhoid control program, particularly in light of the increasing burden of ...
Carey, ME, Diaz, ZI, Broadstock, M, Bailey, R, Bentsi-Enchill, AD, Larson, HJ   +5 more
openaire   +4 more sources

Typhoid Conjugate Vaccine: A Boon for Endemic Regions. [PDF]

Cureus
Typhoid fever has the highest disease burden in countries in low- and middle-income countries, primarily located in Asia and Sub-Saharan Africa. Previous typhoid vaccines such as the live attenuated typhoid (Ty21a) vaccine and Vi (virulence) capsular polysaccharide vaccine had the limitation that they could not be administered with other standard ...
Agarwal N, Gupta N, Nishant, H S S, Dutta T, Mahajan M.   +5 more
europepmc   +3 more sources

Efficacy of typhoid conjugate vaccine in Nepal: final results of a phase 3, randomised, controlled trial

The Lancet Global Health, 2021
Summary: Background: Typhoid fever is a major public health problem in low-resource settings. Vaccination can help curb the disease and might reduce transmission.
Mila Shakya, MPH, Merryn Voysey, DPhil, Katherine Theiss-Nyland, PhD, Rachel Colin-Jones, MA, Dikshya Pant, FCPS, Anup Adhikari, MA, Susan Tonks, BSc, Yama F Mujadidi, MSc, Peter O’Reilly, MBBCh, Olga Mazur, MSc, Sarah Kelly, MSc, Xinxue Liu, PhD, Archana Maharjan, MA, Ashata Dahal, MPH, Naheeda Haque, PharmD, Anisha Pradhan, BSc, Suchita Shrestha, MPH, Manij Joshi, BPharm, Nicola Smith, MBBCh, Jennifer Hill, PhD, Jenny Clarke, PhD, Lisa Stockdale, PhD, Elizabeth Jones, BMedSc, Timothy Lubinda, MSc, Binod Bajracharya, MD, Sabina Dongol, DPhil, Abhilasha Karkey, DPhil, Stephen Baker, ProfPhD, Gordan Dougan, ProfPhD, Virginia E Pitzer, ScD, Kathleen M Neuzil, ProfMD, Shrijana Shrestha, ProfMD, Buddha Basnyat, ProfFRCPE, Andrew J Pollard, ProfFMedSci   +33 more
doaj   +3 more sources