Results 41 to 50 of about 2,440 (155)

Estimating the economic burden of typhoid in children and adults in Blantyre, Malawi: A costing cohort study

PLoS ONE, 2022
Background Typhoid causes preventable death and disease. The World Health Organization recommends Typhoid Conjugate Vaccine for endemic countries, but introduction decisions depend on cost-effectiveness.
Fumbani Limani, Christopher Smith, Richard Wachepa, Hlulose Chafuwa, James Meiring, Patrick Noah, Pratiksha Patel, Priyanka D. Patel, Frédéric Debellut, Clint Pecenka, Melita A. Gordon, Naor Bar-Zeev   +11 more
doaj   +2 more sources

Immune response of S. Typhi-derived Vi polysaccharide and outer membrane protein a conjugate in mice

Pediatrics and Neonatology, 2023
Typhoid fever is a serious concern precisely in developing nations. Still investigators are exploring a better conjugate partner for Vi-polysaccharide to develop a more effective vaccine for typhoid fever. Here, we cloned and expressed S.
Shabirul Haque, Sanjukta Sengupta, Azhar Khan, Asok Kumar Mukhopadhyay, Maharaj Kishan Bhan, Ramesh Kumar, Bansilal Jailkhani   +6 more
doaj   +1 more source

Prevention of enteric fever in travellers with typhoid conjugate vaccines [PDF]

Journal of Travel Medicine, 2018
The 2018 WHO position paper on typhoid vaccines indicates preference for the use of new generation typhoid conjugate vaccines over existing parenteral Vi-polysaccharide (Vi-PS) and oral attenuated Ty21a ...
Britto, C, Jin, C, Theiss-Nyland, K, Pollard, A   +3 more
openaire   +2 more sources

Conjugate vaccines for enteric fever: proceedings of a meeting organized in New Delhi, India in 2009

Journal of Infection in Developing Countries, 2010
Enteric fever is responsible for significant morbidity in South Asia and high prevalence of severe disease is seen in children under two years of age. Effective typhoid vaccines are available, but they cannot be used for children under two years of age
Audino Podda, Allan James Saul, Rashmi Arora, Zulfiqar Bhutta, Anju Sinha, Rajni Gaind, Tanu Singhal, Samir Saha, Abdullah Brooks, Laura B. Martin, Yeshwant Amdekar, Amar Jeet Chitkara, Mae Shieh, Ambujam Nair Kapur, Tulsi Das Chugh   +14 more
doaj   +1 more source

Predicting the Impact of Typhoid Conjugate Vaccines on Antimicrobial Resistance [PDF]

Clinical Infectious Diseases, 2019
Abstract Background Empiric prescribing of antimicrobials in typhoid-endemic settings has increased selective pressure on the development of antimicrobial-resistant Salmonella enterica serovar Typhi.
Kaufhold, Samantha, Yaesoubi, Reza, Pitzer, Virginia E   +2 more
openaire   +2 more sources

Parting the Clouds over Typhoid with a New Conjugate Vaccine [PDF]

New England Journal of Medicine, 2019
Typhoid fever is caused by fecal–oral transmission of Salmonella enterica serovar Typhi (S. Typhi).
Marks, Florian, Kim, Jerome H
openaire   +2 more sources

Synthetic O‐Polysaccharide Backbone Units for a Single Antigen Vaccine Against Two Major Non‐Typhoidal Salmonella Serovars

Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.
A modular strategy was developed to synthesize tri‐, hexa‐, and nona‐saccharides representing repeating units of the conserved O‐polysaccharide backbone of Salmonella. Conjugates of these glycans to bacteriophage Qβ induced strong IgG responses in mice and rabbits. Antibodies elicited recognized native O‐polysaccharides and conferred protection against
Xingling Pan, Changxin Huo, Soham Maity, Herbert Kavunja, Rachel Moszyk, Cameron Talbot, Scott M. Baliban, Xuefei Huang   +7 more
wiley   +2 more sources

Evaluation of Typhoid Conjugate Vaccine Effectiveness in Ghana (TyVEGHA) Using a Cluster-Randomized Controlled Phase IV Trial: Trial Design and Population Baseline Characteristics

Vaccines, 2021
Typhoid fever remains a significant health problem in sub-Saharan Africa, with incidence rates of >100 cases per 100,000 person-years of observation. Despite the prequalification of safe and effective typhoid conjugate vaccines (TCV), some uncertainties ...
Andrea Haekyung Haselbeck, Birkneh Tilahun Tadesse, Juyeon Park, Malick M. Gibani, Ligia María Cruz Espinoza, Ariane Abreu, Craig Van Rensburg, Michael Owusu-Ansah, Sampson Twuamsi-Ankrah, Michael Owusu, Isaac Aguna, Valentina Picot, Hyonjin Jeon, Ellen Higginson, Sunju Park, Zenaida R. Mojares, Justin Im, Megan E. Carey, Farhana Khanam, Susan Tonks, Gordon Dougan, Deokryun Kim, Jonathan Sugimoto, Vittal Mogasale, Kathleen M. Neuzil, Firdausi Qadri, Yaw Adu-Sarkodie, Ellis Owusu-Dabo, John Clemens, Florian Marks   +29 more
doaj   +1 more source

Shifting Enteric Fever Epidemiology in children in Nepal: Is the Burden of Paratyphi on the Rise?

Journal of Nepal Medical Association
Nepal has a high burden of enteric fevers. An observational study conducted in a tertiary-level hospital in Nepal over 11 years (2014–2024), reviewing hospital records of all blood culture-positive cases of Salmonella Typhi and Paratyphi in children ...
Shrijana Shrestha, Sanjeev Man Bijukchhe, Saugat Bhandari, Meeru Gurung   +3 more
doaj   +1 more source

Toward Control? The Prospects and Challenges of Typhoid Conjugate Vaccine Introduction [PDF]

Clinical Infectious Diseases, 2019
Abstract With a newly World Health Organization (WHO)–prequalified typhoid conjugate vaccine (TCV), Gavi funding for eligible countries, and a WHO policy recommendation for TCV use, now is the time for countries to introduce TCVs as part of an integrated typhoid control program, particularly in light of the increasing burden of ...
Carey, ME, Diaz, ZI, Broadstock, M, Bailey, R, Bentsi-Enchill, AD, Larson, HJ   +5 more
openaire   +2 more sources