Results 161 to 170 of about 950,345 (395)

Probiotic‐Based Materials as Living Therapeutics

Advanced Materials, EarlyView.
Recent advances in Engineered Living Materials are highlighted, integrating synthetic biology and advanced materials, with a focus on probiotic‐based therapeutics. Probiotic Living Materials hold great potential for biosensing, infection treatment, osteogenesis, wound healing, vaginal and gastrointestinal disorders, and cancer therapy. breakthroughs in
Laura Sabio, Graham J. Day, Manuel Salmeron‐Sanchez   +2 more
wiley   +1 more source

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

A novel Bruton's tyrosine kinase inhibitor JDB175 shows potent efficacy to suppress central nervous system lymphoma [PDF]

, 2023
Yong Xia, Xue Li, Ning Jiang, Xiawei Wei
openalex   +1 more source

The Bionic Interface: Considering the Material Mediated Electrical Stimulation of Stem Cells

Advanced Materials, EarlyView.
Electrical stimulation directs stem cell fate in tissue engineering. Cellular responses are influenced by membrane properties, intrinsic cell state, material charge‐transport characteristics, and the applied electrical signal. Additionally, a material’s ability to inject, store, and redistribute charge further modulates these responses.
Kaiwen Zhang, Daniel De Maria, Mercyjayapriya Jebakumar, James Collins, Kate E. Fox, Peter C. Sherrell, Amy Gelmi   +6 more
wiley   +1 more source

Mesenchymal Stem Cell‐Inspired Microneedle Platform for NIR‐responsive Immunomodulation and Accelerated Chronic Wound Healing

Advanced Materials, EarlyView.
The research demonstrates a Mesenchymal Stem Cell‐inspired microneedle platform (MSCi@MN) that addresses chronic diabetic wounds by combining MSC‐derived extracellular nanovesicles (NV)–DNA conjugates in microneedle tips with photothermal MXene in the patch layer.
Chan Ho Moon, Hee Gyeong Ko, Hyun Lee, Seojoon Bang, Hyeong Seok Kang, Ju Yeong Gwon, Jong Hwa Seo, Nayoung Lee, So Won Jeon, Yun‐A Kim, Jong Sang Yoon, Kyung‐Yup Cha, Min‐Ho Kang, Dong Yun Lee, Soo‐Hong Lee, Gi Doo Cha, Kisuk Yang, Donghyun Lim, Heemin Kang, Su Ryon Shin, Han Young Kim, Hyun‐Do Jung   +21 more
wiley   +1 more source

Cabozantinib for progressive metastatic medullary thyroid cancer: a review

Therapeutics and Clinical Risk Management, 2014
Joshua R Colombo, Richard O Wein Department of Otolaryngology, Head and Neck Surgery, Tufts Medical Center, Boston, MA, USA Abstract: Medullary thyroid cancer is uncommon and patients typically present with advanced disease.
Colombo JR, Wein RO
doaj  

Engineering of an Ancestral McbA with Enhanced Domain Mobility Extends Biocatalytic Amide Synthesis Scope

Advanced Synthesis &Catalysis, EarlyView.
We show how engineered ancestral amide bond synthetases (ABSs) together with cofactor recycling using a single polyphosphate kinase paves the way for chemoenzymatic synthesis of pharmacophores. The figure illustrates how ancestral ABS has a more flexible C‐terminal domain, which is associated with enhanced catalytic performance and expanded amine scope.
Elisabeth Söderberg, Marianne R. Molenaar, Katarzyna Zaczyk, Magnus Johansson, Martin A. Hayes, Per‐Olof Syrén   +5 more
wiley   +1 more source

Radiographic assessment and therapeutic decisions at RECIST progression in EGFR-mutant NSCLC treated with EGFR tyrosine kinase inhibitors

, 2012
Mizuki Nishino, Stephanie Cardarella, Suzanne E. Dahlberg, David M. Jackman, Nikhil H. Ramaiya, Hiroto Hatabu, Michael S. Rabin, Pasi A. Jnne, Bruce E. Johnson   +8 more
openalex   +2 more sources

Allogeneic Haematopoietic Stem Cell Transplantation for Chronic Myeloid Leukaemia in the Era of Tyrosine Kinase Inhibitors [PDF]

, 2018
Ahmet Emre Eşkazan, Mario Tiribelli
openalex   +1 more source

CRISPR‐MI and scRNA‐Seq Reveal TREM2's Function in Monocyte Infiltration and Macrophage Apoptosis During Abdominal Aortic Aneurysm Development

Advanced Science, EarlyView.
A method is developed for conducting genome‐wide CRISPR/Cas9 screening of monocyte infiltration in vivo (CRISPR‐MI) that is easily adaptable across a variety of disease models. Through the combination of CRISPR‐MI and scRNA‐Seq, this study discovers that Trem2 is a key regulator of early monocyte infiltration in abdominal aortic aneurysm (AAA ...
Haocheng Lu, Chao Xue, Yang Zhao, Jinjian Sun, Changzhi Zhao, Xu Zhang, Guizhen Zhao, Yaozhong Liu, Hongyu Liu, Yongjie Deng, Ying Wang, Chi Zhang, Yingjie Liu, Linjun Zeng, Ying Yang, Bolun Li, Shusi Ding, Linkang Zhou, Henry Kuang, Zanxin Wang, Wenhao Ju, Haihuan Lin, Jie Lin, Yanhong Guo, Lin Chang, Hongmei Zhao, Jing Wang, Jiandie Lin, Lemin Zheng, Y. Eugene Chen, Jifeng Zhang   +30 more
wiley   +1 more source