Results 171 to 180 of about 950,345 (395)

High-efficiency liposomal encapsulation of a tyrosine kinase inhibitor leads to improved in vivo toxicity and tumor response profile

International Journal of Nanomedicine, 2013
Rajesh Mukthavaram,1 Pengfei Jiang,1 Rohit Saklecha,1 Dmitri Simberg,3,4 Ila Sri Bharati,1 Natsuko Nomura,1 Ying Chao,1 Sandra Pastorino,1 Sandeep C Pingle,1 Valentina Fogal,1 Wolf Wrasidlo,1,2 Milan Makale,1,2 Santosh Kesari1,21Translational Neuro ...
Mukthavaram R, Jiang P, Saklecha R, Simberg D, Bharati IS, Nomura N, Chao Y, Pastorino S, Pingle SC, Fogal V, Wrasidlo W, Makale M, Kesari S   +12 more
doaj  

Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastrointestinal stromal tumor.

New England Journal of Medicine, 2001
H. Joensuu, P. Roberts, M. Sarlomo‐Rikala, Leif C. Andersson, P. Tervahartiala, David A. Tuveson, David A. Tuveson, S. Silberman, R. Capdeville, S. Dimitrijević, B. Druker, G. Demetri   +11 more
semanticscholar   +1 more source

Mechanobiological Dynamics‐Inspired Mechanomodulatory Biomaterials

Advanced Science, EarlyView.
Recent advances in biomaterial‐mediated mechanomodulation of stem cell fate, encompassing 2, 3, and 4D systems and their synergy with artificial intelligence is overviewed. By integrating knowledge from diverse fields, this review ultimately aims to inspire the design of smarter biomaterial systems that can accelerate the clinical translation of ...
Letao Yang, Pengfei Jiang, Joshua B Stein, Yannan Hou, Chaochen Zhou, Heemin Kang, Ki‐Bum Lee   +6 more
wiley   +1 more source

Targeting the tumor-promoting microenvironment in MET-amplified NSCLC cells with a novel inhibitor of pro-HGF activation [PDF]

, 2017
Galemmo, Robert A, Jr, Han, Zhenfu, Janetka, James W, Klampfer, Lidija, Owusu, Benjamin Y, Thomas, Shantasia, Venukadasula, Phanindra   +6 more
core   +2 more sources

Obesity‐Associated TRIM15 Promotes the Proliferation of Esophageal Adenocarcinoma Through the YY2/FOXRED1 Axis

Advanced Science, EarlyView.
The study identifies TRIM15 as a key driver in the development of obesity‐associated esophageal adenocarcinoma (EAC). Mechanistically, TRIM15 degrades YY2 through the proteasome pathway, suppressing FOXRED1 transcription and ultimately accelerating tumor proliferation.
Haohui Wang, Chong Yang, Dayuan Luo, Pingting Liu, Zhen Zeng, Weilin Peng, Dongzi Peng, Hao Su, Xiaoxiong Xiao, Haiqin Wang, Xin Jin   +10 more
wiley   +1 more source

Allogeneic Stem Cell Transplantation versus Tyrosine Kinase Inhibitors Combined with Chemotherapy in Patients with Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia

, 2017
Jing Wang, Qian Jiang, Lan‐Ping Xu, Xiaohui Zhang, Huan Chen, Ya‐Zhen Qin, Guo‐Rui Ruan, Hao Jiang, Jinsong Jia, Ting Zhao, Kai‐Yan Liu, Bin Jiang, Xiao‐Jun Huang   +12 more
openalex   +1 more source

Metformin Restores Mitochondrial Function and Neurogenesis in POLG Patient‐Derived Brain Organoids

Advanced Science, EarlyView.
Patient‐derived POLG‐mutant cortical organoids reveal neuronal subtype‐specific mitochondrial and synaptic defects, with dopaminergic neurons most affected. Metformin treatment restores neuronal identity, mitochondrial function, and excitability, increased mtDNA maintenance, and reprogrammed metabolism via TCA and redox pathways.
Zhuoyuan Zhang, Tsering Yangzom, Ning Lu, Shenglong Deng, Xianglu Xiao, Guang Yang, Kristina Xiao Liang   +6 more
wiley   +1 more source

Targeting the MET receptor tyrosine kinase in non-small cell lung cancer: emerging role of tivantinib

Cancer Management and Research, 2014
Eberechi S Agwa, Patrick C MaTranslational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USAAbstract: MET receptor tyrosine kinase and its natural ligand, hepatocyte growth factor, have been implicated in a ...
Agwa ES, Ma PC
doaj  

Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome.

New England Journal of Medicine, 2001
B. Druker, C. Sawyers, H. Kantarjian, D. Resta, Sofia Fernandes Reese, J. Ford, R. Capdeville, M. Talpaz   +7 more
semanticscholar   +1 more source

Tyrosine kinase inhibitors [PDF]

Cancer Cell, 2004
Arteaga, Carlos L., Baselga, Jose
openaire   +1 more source