Results 181 to 190 of about 950,345 (395)
Type II Alveolar Epithelial Cells Promote Sepsis‐Induced Immunosuppression in Alveolar Macrophages via Exosomal lncRNA Rmrp Release
Advanced Science, EarlyView.The S100A4/STAT3 axis promotes Rmrp transcription in AEC‐IIs and Rmrp expression in AEC‐II‐derived exosomes. Upon entry into AMs, Rmrp binds to and blocks the ubiquitination and degradation of ZFP36. Increased ZFP36 induced Pfkfb3 mRNA decay by binding to AREs in the 3′ UTR, curbing glycolysis and immune responses of AMs and aggravating SII and ...Chengxi Liu, Weixia Xuan, Song Cao, Huayun Jia, Qian Wu, Xiaowu Tan, Qijie Wang, Xiaojun Li, Lisha Ding, Yaru Xiong, Meiyun Zhao, Longcheng Zheng, Yunzhu Xi, Jianhua Tan, Rong Li, Xulong Zhang, Wenjie Liu, Xu Wu +17 morewiley +1 more sourceMetastatic Perivascular Epithelioid Cell Tumor Of The Kidney: A Case Report With Emphasis On Response To The Tyrosine-Kinase Inhibitor Sunitinib
Research and Reports in Urology, 2019 Rami S AlAzab,1 Mohammed S Alorjani,2 Firas E Sahawneh,1 Sana Al-Sukhun3 1Urology Division, Department of Surgery, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan; 2Department of Pathology and Microbiology, Faculty of ...AlAzab RS, Alorjani MS, Sahawneh FE, Al-Sukhun S +3 moredoaj Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib.
New England Journal of Medicine, 2014 J. Woyach, R. Furman, Ta-Ming Liu, H. Ozer, M. Zapatka, A. Ruppert, L. Xue, Daniel Li, S. Steggerda, M. Versele, S. Dave, Jenny Zhang, A. S. Yilmaz, S. Jaglowski, K. Blum, A. Lozanski, G. Lozanski, D. James, J. Barrientos, P. Lichter, S. Stilgenbauer, J. Buggy, B. Chang, A. Johnson, J. Byrd +24 moresemanticscholar +1 more sourceCircPVT1 Promotes Lung Metastasis and Tumor Progression in Renal Cell Carcinoma by Encoding the cP104aa Peptide and Targeting EIF4A3
Advanced Science, EarlyView.This study reveals that circPVT1 promotes the renal cell carcinoma lung metastasis and tumor progression through encoding the cP104aa peptide and directly binds with EIF4A3, which jointly regulates the target gene c‐MYC. Abstract
Circular RNA (circRNA) plays a pivotal role in the pathogenesis of renal cell carcinoma (RCC).Houliang Zhang, Tao Tao, Jie Ji, Tonglei Zhao, Si Sun, Lijie Zhang, Jianping Wu, Ming Chen, Shuqiu Chen, Bin Xu, Weipu Mao +10 morewiley +1 more source29P Brigatinib (BRG) vs crizotinib (CRZ) in anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor-naive ALK+ non-small cell lung cancer (NSCLC): ALTA-1L final results
, 2022 Marcello Tiseo, Sanjay Popat, Hye Ryun Kim, M-J. Ahn, Jin Yang, J-Y. Han, Maximilian J. Hochmair, K.H. Lee, Angelo Delmonte, M.R. García Campelo, Dongwook Kim, Frank Griesinger, Enriqueta Felip, Raffaele Califano, A.I. Spira, Scott Gettinger, Huimin Lin, Y. Liu, Florin Vranceanu, D. Ross Camidge +19 moreopenalex +2 more sourcesNNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring
Advanced Science, EarlyView.In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai +11 morewiley +1 more sourceSupplementary Table 2 from Impact of <i>TP53</i> Mutations on Outcome in <i>EGFR</i>-Mutated Patients Treated with First-Line Tyrosine Kinase Inhibitors
, 2023 Matteo Canale, Elisabetta Petracci, Angelo Delmonte, Elisa Chiadini, Claudio Dazzi, Maximilian Papi, Laura Capelli, Cláudia Casanova, Nicoletta De Luigi, Marita Mariotti, Alessandro Gamboni, Rita Chiari, Chiara Bennati, Daniele Calistri, Vienna Ludovini, Lucio Crinò, Dino Amadori, Paola Ulivi +17 moreopenalex +1 more sourceThe Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy
Proceedings of the National Academy of Sciences of the United States of America, 2010 L. Honigberg, Ashley M. Smith, M. Sirisawad, E. Verner, D. Loury, B. Chang, Shyr-Jiann Li, Z. Pan, D. Thamm, Richard A. Miller, J. Buggy +10 moresemanticscholar +1 more source
