Results 71 to 80 of about 950,196 (257)
Systemic treatment for hepatocellular carcinoma
Chronic Diseases and Translational Medicine, 2018 Hepatocellular carcinoma (HCC) is one of the most common cancers with high mortality worldwide. Treatment options for patients with advanced stage HCC remain a great challenge. However, novel agents especially small molecule tyrosine kinase inhibitor and
Manushi Aggarwal +2 more
doaj +1 more source
Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility. [PDF]
, 2011 BackgroundCell migration plays an important role in many physiological and pathological processes, including immune cell chemotaxis and cancer metastasis.
Liao, Kan, Liu, Yang, Wang, Wenqi
core +2 more sources
Tuberculosis and Respiratory Diseases, 2016 Somatic mutations that lead to hyperactivation of epidermal growth factor receptor (EGFR) signaling are detected in approximately 50% of lung adenocarcinoma in people from the Far East population and tyrosine kinase inhibitors are now the standard first ...
Y. Chang, Chang-Min Choi, Jae Cheol Lee
semanticscholar +1 more source
Клиническая онкогематология, 2018 Background. Kinase domain mutations of BCR-ABL gene is the most common cause of tyrosine kinase inhibitor resistance. Aim. To present the data on prognostic value of BCR-ABL mutation burden in Russian patients over the last 10 years.
Vera Vyacheslavovna Tikhonova +9 more
doaj +1 more source
Tyrosine kinase inhibition produces specific alterations in axon guidance in the grasshopper embryo [PDF]
, 1998 Tyrosine kinase signaling pathways are essential for process outgrowth and guidance during nervous system development. We have examined the roles of tyrosine kinase activity in programming growth cone guidance decisions in an intact nervous system in ...
Menon, Kaushiki P., Zinn, Kai
core
Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53 independent pathways [PDF]
, 2014 Most cancer cells use aerobic glycolysis to fuel their growth. The enzyme lactate dehydrogenase-A (LDH-A) is key to cancer’s glycolytic phenotype, catalysing the regeneration of nicotinamide adenine dinucleotide (NAD þ ) from reduced nicotinamide adenine
Allison, Simon J. +6 more
core +1 more source
Preclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model [PDF]
, 2022 Hiroshi Ikeuchi +6 more
openalex +1 more source
Frontiers in Oncology, 2020 Numerous recurrent genetic mutations are known to occur in acute myeloid leukemia (AML). Among these common mutations, Fms-like tyrosine kinase 3 remains as one of the most frequently mutated genes in AML.
Kran Suknuntha +9 more
doaj +1 more source
CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation [PDF]
, 2003 CD40 is a 48-kDa phosphorylated transmembrane glycoprotein belonging to the TNF receptor superfamily. CD40 has been demonstrated on a range of cell types, and it has an important role in adaptive immunity and inflammation.
Callard, R.E. +4 more
core
Rapamycin induces transactivation of the EGFR and increases cell survival. [PDF]
, 2009 The mammalian target of rapamycin (mTOR) signaling network regulates cell growth, proliferation and cell survival. Deregulated activation of this pathway is a common event in diverse human diseases such as cancers, cardiac hypertrophy, vascular ...
Chaturvedi, D +4 more
core +2 more sources