Results 251 to 260 of about 664,087 (343)

SIRT4 Promotes Pancreatic Cancer Stemness by Enhancing Histone Lactylation and Epigenetic Reprogramming Stimulated by Calcium Signaling

Advanced Science, EarlyView.
As a downstream target of α2δ1‐mediated calcium signaling, SIRT4 serves as an oncogene to promote the stemness of pancreatic cancer via deacetylating ENO1 directly at K358, leading to attenuated ENO1's RNA‐binding capacity, enhanced glycolytic substrate 2‐PG binding and robust glycolytic activity to increase the level of lactate that induce histone ...
Mengzhu Lv, Xiaodan Yang, Congcong Xu, Qingru Song, Hailian Zhao, Tianjiao Sun, Jingtao Liu, Yuan Zhang, Guogui Sun, Yuanchao Xue, Zhiqian Zhang   +10 more
wiley   +1 more source

THE METABOLISM IN VITRO OF TYROSINE BY LIVER AND KIDNEY TISSUES OF NORMAL AND VITAMIN C-DEFICIENT GUINEA PIGS

, 1944
Tien Ho Lan, Robert Ridgely Sealock
openalex   +1 more source

Kinome profiling reveals pathogenic variant specific protein signalling networks in MEN2 children with Medullary Thyroid Cancer. [PDF]

NPJ Precis Oncol
Rix B, Chauhan R, Masoumi Z, Grönroos E, Brain CE, Ogunbiyi OK, Swarbrick K, Swanton C, Bonnet D, Kurzawinski TR, Izatt L, McDonald NQ, Grey W.   +12 more
europepmc   +1 more source

DNA‐PKcs‐Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia‐Induced Cardiac Dysfunction in Type 1 Diabetes

Advanced Science, EarlyView.
In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang, Xing Chang, Chun Li, Jing Gao, Zhijiang Guo, Haowen Zhuang, Lingjun Wang, Yusheng Huang, Wei Wang, Chao Li, Qingyong He   +10 more
wiley   +1 more source

AN ENZYMATIC METHOD FOR THE DETECTION AND ESTIMATION OF TYROSINE IN URINE

, 1929
S. S. Lichtman, Harry Sobotka
openalex   +1 more source

Cnicin: a promising drug for promoting nerve repair. [PDF]

Front Cell Dev Biol
Fischer D.
europepmc   +1 more source

CPL‐Diff: A Diffusion Model for De Novo Design of Functional Peptide Sequences with Fixed Length

Advanced Science, EarlyView.
This study presents a diffusion model for generating functional peptide sequence lengths using mask control. The model can generate antimicrobial, antifungal, and antiviral peptides with specific lengths on demand. The model learns the structure of peptides better and generates peptides with better physicochemical properties, and the model has good ...
Zhenjie Luo, Aoyun Geng, Leyi Wei, Quan Zou, Feifei Cui, Zilong Zhang   +5 more
wiley   +1 more source

SOLUBILITY OF GLYCINE, LEUCINE, AND TYROSINE IN LIQUID AMMONIA

, 1949
John B. Zachary, Walter J. Moore
openalex   +1 more source

Targeting kinases that regulate programmed cell death: a new therapeutic strategy for breast cancer. [PDF]

J Transl Med
Hong Y, He J, Deng D, Liu Q, Zu X, Shen Y.   +5 more
europepmc   +1 more source

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai   +12 more
wiley   +1 more source