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Tyrosine Kinase Inhibitors

2016
Breast cancer is the most common cancer in women worldwide. Although various subgroups are defined according to the expression of hormones and ErbB family receptors, it is well known that this disease is more heterogeneous than its classification system suggests.
Cakar B., Göker E.
openaire   +2 more sources

Biosynthesis of β-tyrosine

Biochimica et Biophysica Acta (BBA) - General Subjects, 1972
Abstract 1. 1. An enzyme: tyrosine α,β-amino mutase was isolated from cells of Bacillus brevis Vm4. 2. 2. Tyrosine α,β-amino mutase forms β-tyrosine from L -α-tyrosine. 3. 3. The optimal conditions for the reaction are at pH 8.5 and 37°C. 4. 4. ATP is the only cofactor required for the enzyme activity. 5. 5.
Z, Kurylo-Borowska, T, Abramsky
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Targeted tyrosine iodination in a multi‐tyrosine vasopressin analog

Journal of Peptide Science, 2007
AbstractIodination of the conserved 2‐tyrosine (Tyr2) residue in the pressin and tocin rings of arginine‐ or lysine‐vasopressin (AVP or LVP), and oxytocin, respectively, impairs binding to their respective receptors. Synthetic antagonists that have their Tyr2 either replaced by another amino acid or irreversibly blocked by an O‐methyl or O‐ethyl ether,
Jacques A, Durr   +3 more
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PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

Science, 1997
Jing Li   +16 more
semanticscholar   +1 more source

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells

Nature Medicine, 1996
B. Druker   +7 more
semanticscholar   +1 more source

Regulation of Tyrosine Kinases by Tyrosine Phosphorylation

1991
Protein kinases can be classified according to whether they phosphorylate phenolic (tyrosine) or aliphatic (serine and threonine) hydroxyl groups (Hunter and Cooper, 1985). Although there are now a few examples of kinases that seemingly break the rule (Howell et al., 1990), most tyrosine kinases differ from the serine/threonine kinases in their primary
Jonathan A. Cooper   +2 more
openaire   +1 more source

Study of Tyrosine Kinases and Protein Tyrosine Phosphorylation

2004
In recent years, our increased understanding of the complex signal transduction mechanisms that regulate cellular function has fueled huge advances in all aspects of biomedical science and cell biology. Platelet and megakaryocyte function is no exception to this. In the last 10 yr our understanding of the receptor biochemistry and the systems that they
openaire   +2 more sources

A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat

Nature Biotechnology, 2019
Yiran Yang   +12 more
semanticscholar   +1 more source

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