Results 291 to 300 of about 664,087 (343)

First-Line Ipilimumab with Nivolumab versus Immune Checkpoint Inhibitors with Tyrosine Kinase Inhibitors in Patients with Intermediate- or Poor-Risk Metastatic Clear Cell Renal Cell Carcinoma. [PDF]

J Kidney Cancer VHL
Ostrowski M, Jo Y, Gebrael G, Chehade CH, Ozay ZI, Nordblad B, Srivastava A, Garg D, Ji R, Fortuna GG, Thomas VM, Chigarira B, Anderson E, Agarwal N, Maughan BL, Swami U.   +15 more
europepmc   +1 more source

COPS5 Triggers Ferroptosis Defense by Stabilizing MK2 in Hepatocellular Carcinoma

Advanced Science, EarlyView.
COPS5, which is overexpressed in HCC in an amplification‐ and ATF4‐dependent manner, stabilizes MK2 through deubiquitination and, in turn, induces HSPB1 activation, protecting HCC cells from ferroptosis and thus promoting sorafenib resistance and tumor progression. Abstract Sorafenib, which is proven to serve as a potent ferroptosis inducer, is used as
Ai‐Ling Luo, Wen‐Ying Zheng, Qiong Zhang, Yan Yuan, Mei‐Qi Li, Kai Du, An‐Ran Gao, Li‐Jun Pei, Jie Xie, Wen‐Hao Chen, Long Zhang, Xiu‐Zhu Guo, Xiao‐Ran Yang, Chao Zeng, Guo‐Hua Yang, Min Deng   +15 more
wiley   +1 more source

The Impact of SGLT-2 Inhibitors on Hydroxyl Radical Markers and Diabetic Neuropathy: A Short-Term Clinical Study. [PDF]

Antioxidants (Basel)
Klabuzai Á, Bekő V, Sütő Z, Horváth M, Wágner Z, Vágási K, Pfeil V, Süle M, Grosz G, Wittmann I, Kun S.   +10 more
europepmc   +1 more source

Cardiomyocyte‐Enriched USP20 Ameliorates Pathological Cardiac Hypertrophy by Targeting STAT3 Deubiquitination

Advanced Science, EarlyView.
Cardiomyocyte‐enriched USP20 regulates the K63‐linked ubiquitination of STAT3, and the cardiomyocyte‐specific USP20‐STAT3‐CARM1 axis exerts a protective role in cardiac hypertrophy. Targeting USP20 through cardiac‐specific gene therapy presents a promising strategy for the treatment of cardiac hypertrophy.
Lingfeng Zhong, Shanshan Dai, Fan Yu, Guo‐Ping Shi, Qinyan Gong, Yucong Zhang, Jingsi Duan, Zhengyin Lou, Zhixuan Tang, Fuzhe Gong, Derong Chen, Liya Hou, Xinyang Hu, Jinghai Chen, Jian'an Wang, Deling Yin   +15 more
wiley   +1 more source

Gram-negative bacteria activate cellular pathways in plaque microenvironment; Systems biology approach. [PDF]

BMC Microbiol
Ganjali R, Elahimanesh M, Aghazadeh H, Najafi M.   +3 more
europepmc   +1 more source

Substrate binding of human and bacterial type IA topoisomerase: An experimentation with AlphaFold 3.0. [PDF]

Comput Struct Biotechnol J
Mamun Y, Aguado A, Preza A, Kadel A, Mogallur A, Gonzalez B, De La Rosa J, Diaz D, Evdokimova P, Karki U, Tse-Dinh YC, Chapagain P.   +11 more
europepmc   +1 more source

Unraveling the Metabolic and Microbiome Signatures in Fecal Samples of Pregnant Women with Prenatal Depression. [PDF]

Metabolites
Li J, Mei PC, An N, Fan XX, Liu YQ, Zhu QF, Feng YQ.   +6 more
europepmc   +1 more source

Investigation of Eumelanin Biosynthesis in <i>Gluconacetobacter tumulisoli</i> FBFS 97: A Novel Insight into a Bacterial Melanin Producer. [PDF]

Microorganisms
Song J, Ma Y, Xie Z, Chen F.
europepmc   +1 more source

The Involvement of Amino Acid Metabolism in the Mechanisms of Salt Tolerance Adaptation in <i>Medicago sativa</i> and <i>Medicago truncatula</i>. [PDF]

Plants (Basel)
Shen S, Pan L, Li J, Wang J, Ahmad I, Liu H, Bai Y, Kang B, Yin J, Gao Y, Lu Y, Wang X.   +11 more
europepmc   +1 more source

Insights into the Role of GhTAT2 Genes in Tyrosine Metabolism and Drought Stress Tolerance in Cotton. [PDF]

Int J Mol Sci
Mehari TG, Tang J, Gu H, Fang H, Han J, Zheng J, Liu F, Wang K, Yao D, Wang B.   +9 more
europepmc   +1 more source