Results 41 to 50 of about 880,315 (306)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Tyrosine-Decorated Gold Nanoclusters Chelated Cerium(III) for Fluorescence Detection of Dopamine
, 2021 In this work, a tyrosine-decorated gold nanocluster (Tyr-GNC)–cerium(III) complex was established for the fluorescent detection of dopamine (DA). Tris–HCl buffer was used for synthesizing Tyr-GNC; thus, Tyr-GNC could emit fluorescence even under neutral
Fang-Nan Wu +9 more
core +1 more source
Czech Journal of Food Sciences, 2006 This review article gives a survey of principal pathways that lead to the biosynthesis of the proteinogenic amino acids of the alanine-valine-leucine group starting with pyruvic acid from the glycolytic pathway and serine-cysteine-glycine group starting ...
Jan Velíšek, Karel Cejpek
doaj +1 more source
Frontiers in Oncology, 2021 The use of patient-derived primary cell cultures in cancer preclinical assays, including drug screens and genotoxic studies, has increased in recent years.
Ahmad Najem +17 more
doaj +1 more source
Structural basis of tubulin tyrosination by tubulin tyrosine ligase [PDF]
Journal of Cell Biology, 2013 Tubulin tyrosine ligase (TTL) catalyzes the post-translational retyrosination of detyrosinated α-tubulin. Despite the indispensable role of TTL in cell and organism development, its molecular mechanism of action is poorly understood. By solving crystal structures of TTL in complex with tubulin, we here demonstrate that TTL binds to the α and β subunits
Prota Andrea E. +10 more
openaire +4 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
, 2018 Here, we show that aromatic amino acid tyrosine, under a physiologically mimicking condition, readily forms amyloid-like entities that can effectively drive aggregation of different globular proteins and aromatic residues. Tyrosine self-assembly resulted
Bibin G. Anand (1697590) +7 more
core +1 more source
, 2020 A Black dots represent per participant the difference scores (tyrosine minus placebo) of the slope of the subjective value as a function of N-back levels. Negative scores reflect more pronounced discounting (i.e.
Roshan Cools (48557) +4 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
NukleonikaThe mechanisms of the reversible oxidative deamination of l-tyrosine to p-hydroxyphenylpyruvic acid and reductive amination of phenylpyruvic acid to l-phenylalanine, both catalyzed by the enzyme l-phenylalanine dehydrogenase (PheDH, EC 1.4.1.20), were ...
Pałka Katarzyna +3 more
doaj +1 more source