Results 121 to 130 of about 486,983 (268)

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Bosutinib induced pleural effusions: Case report and review of tyrosine kinase inhibitors induced pulmonary toxicity

, 2017
Natalia Moguillansky, Hafiz Abdul Moiz Fakih, John R. Wingard   +2 more
openalex   +1 more source

Clinical implication and usefulness of de novo EGFR T790M mutation in lung adenocarcinoma with EGFR-tyrosine kinase inhibitor sensitizing mutation [PDF]

, 2020
Sang Hoon Lee, Eun Young Kim, Arum Kim, Yoon Soo Chang   +3 more
openalex   +1 more source

NNMT Orchestrates Metabolic‐Epigenetic Reprogramming to Drive Macrophage‐Myofibroblast Transition in Hypertrophic Scarring

Advanced Science, EarlyView.
In macrophage‐myofibroblast transition, upregulated NNMT depletes S‐Adenosylmethionine‌ (SAM) and nicotinamide adenine dinucleotide(NAD+), thereby triggering epigenetic reprogramming via Histone H3 Lysine 27 acetylation (H3K27ac) accumulation at the promoter region of master transcription factor Prrx1.
Xiwen Dong, Weinan Guo, Yuxuan Qian, Wenyan Jin, Xiaozhen Li, Jingyuan Yang, Qingrong Ni, Shuang Wu, Fanni Li, Hua Wang, Chunying Li, Hong Cai   +11 more
wiley   +1 more source

Prediction for early progression of metastatic renal cell carcinoma treated with first-line tyrosine kinase inhibitors

, 2020
Jun Teishima, T. Hayashi, Seiya Inoue, Yohei Sekino, Shinsuke Fujii, Kenichiro Ikeda, Keisuke Goto, Akio Matsubara   +7 more
openalex   +1 more source

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Editorial: Targeting Bruton Tyrosine Kinase

Frontiers in Cell and Developmental Biology, 2022
Cornelia Brunner, Annika C. Betzler, Jennifer R. Brown, Amy H. Andreotti, Emanuela Grassilli   +4 more
doaj   +1 more source

Intersection of Tyrosine Kinase Inhibition and Sepsis-Induced Cardiomyopathy. [PDF]

Case Rep Pathol
Abe H, Takasu K, Yamamoto K, Shigeki T, Miyazaki T, Tokano T, Minamino T.   +6 more
europepmc   +1 more source

Targeting the Proline-Rich Tyrosine Kinase 2 /Mitochondrial Calcium Uniporter Pathway, Ruthenium Red, and Nimodipine alone and in Combination Evoked Neuroprotective Effect in Experimentally Induced Brain Stroke in Rats

, 2020
Amany A. Alzokaky
openalex   +1 more source

EIF1AX Nucleolar Condensates Enhance Susceptibilities for the Management of Endometrial Cancer

Advanced Science, EarlyView.
This schematic illustrates the mechanism of a senolytic strategy in endometrial cancer. EIF1AX facilitates the incorporation of DDX21 into nucleolar condensates, an event that suppresses rDNA transcription and induces cellular senescence. The compound 2,5‐MeC exploits this pathway by promoting EIF1AX nucleolar translocation and condensate formation ...
Chengyu Lv, Zihang Lin, Jiandong Sun, Yuhong Ye, Qibin Wu, Liangzhi Cai, Dabin Liu, Pengming Sun, Shie Wang   +8 more
wiley   +1 more source