Results 211 to 220 of about 1,776,183 (353)

RET/PTCandRETTyrosine Kinase Expression in Adult Papillary Thyroid Carcinomas¹ [PDF]

, 1998
Diana Learoyd, Marinella Messina, Jan Zedenius, Ana I. Guinea, Leigh Delbridge, Bruce G. Robinson   +5 more
openalex   +1 more source

A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome.

New England Journal of Medicine, 2003
J. Cools, D. DeAngelo, J. Gotlib, E. Stover, R. Legare, J. Cortes, J. Kutok, Jennifer Hayes Clark, I. Galinsky, J. Griffin, N. Cross, A. Tefferi, J. Malone, R. Alam, S. Schrier, J. Schmid, M. Rose, P. Vandenberghe, G. Verhoef, M. Boogaerts, I. Wlodarska, H. Kantarjian, P. Marynen, S. Coutre, R. Stone, D. Gilliland   +25 more
semanticscholar   +1 more source

Hypoxia‐Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O‐GlcNAcylation

Advanced Science, EarlyView.
Under hypoxia, HIF1A is directly bound to the PRELID2 promoter to increase PRELID2 pre‐mRNA expression, followed by the DYRK1A–SFPQ–SAM68 complex binding to Alu‐containing introns in PRELID2 pre‐mRNA, leading to circPRELID2 circularization. CircPRELID2 interacts with PCBP1 and promotes its cytoplasmic retention.
Pengshan Zhang, Zai Luo, Yitian Xu, Yuan Zhang, Renchao Zhang, Nadina Paerhati, Shaopeng Zhang, Qianqian Cai, Zhengjun Qiu, Chen Huang   +9 more
wiley   +1 more source

Targeting MITF as a tyrosine-kinase-inhibitor-independent strategy for treating GIST. [PDF]

Mol Ther Oncol
Yeung SF, Huang Q, Liang K, Wing Tsui SK.   +3 more
europepmc   +1 more source

Radiolabeled EGFR Tyrosine Kinase for the Detection of Dual Mutations EGFR L858R/T790M in NSCLC

, 2023

openalex   +1 more source

Plant Virus‐Induced Inheritable Apoptosis Drives Reproductive Costs in Female Insect Vectors to Balance Viral Biparental Transmission

Advanced Science, EarlyView.
Rice gall dwarf virus (RGDV), transmitted biparentally by leafhopper vector to their offspring, exploits the capsid protein to induce inheritable ovarian apoptosis via insulin‐driven PI3K/AKT/FoxO signaling axis. This mechanism enhances infection but reduces female reproductive fitness, causing inefficient maternal transmission.
Haibo Wu, Wenqiang Wan, Qingquan Liang, Hengsong Yang, Chengcong Lu, Taiyun Wei, Qian Chen   +6 more
wiley   +1 more source

The Receptor Tyrosine Kinase Axl in (Advanced) Gastric Cancer-From Pathophysiology to Therapeutic Impact. [PDF]

Medicina (Kaunas)
Schreiner OD, Schreiner TG, Miron L, Ciobanu RC.   +3 more
europepmc   +1 more source

ROR1-a Novel Receptor Tyrosine Kinase with Unique Therapeutic Potentials in Chronic Lymphocytic Leukemia

, 2011
Amir Hossein Daneshmanesh
openalex   +1 more source

Lactate Activates the HCAR1/β‐Arrestin2/PP2A Signaling Axis to Mediate STAT1/2 Dephosphorylation and Drive Osteosarcoma Progression

Advanced Science, EarlyView.
In the present study, it is found that in osteosarcoma, lactate‐activated HCAR1 promotes β‐arrestin 2 translocation from cytoplasm to nucleus. In the nucleus, β‐arrestin 2 recruits PP2A to the activated STAT1/2 dimers, mediating STAT1/2 dephosphorylation and inhibiting the transcription of downstream anti‐oncogenes to promote OS progression.
Zhitao Han, Qi Jia, Guangjian Bai, Zhao Li, Jin Zeng, Zhenhua Wang, Jing Zhang, Jiashi Cao, Baoquan Xin, Yonggang Liu, Jingyu Shen, Lining Wang, Xing Huang, Chunlei Zhang, Kai Tong, Fenglei Dai, Yajie Zhang, Weina Zhu, Songyi Cheng, Yuanming Chen, Xinghai Yang, Guanghui Chen, Zhenhua Zhou, Yong Ma, Weibo Liu, Ting Wang, Tielong Liu   +26 more
wiley   +1 more source

Significance of the tyrosine kinase 2 gene in both type 1 and type 2 diabetes. [PDF]

BMJ Open Diabetes Res Care
Nagafuchi S, Mine K, Perveen R, Mori H, Anzai K, Takahashi H.   +5 more
europepmc   +1 more source