Results 311 to 320 of about 787,124 (352)

Superoxide generation and tyrosine kinase

Biochemistry and Cell Biology, 2000
NADPH oxidase is a multi-subunit enzyme complex responsible for superoxide generation in many cells, for example, B-lymphocytes and osteoclasts. NADPH oxidase is localized on the cell surface and generates superoxide extracellularly. After synthesis, components of this oxidase are transported to the cell membrane where the functional NADPH oxidase ...
George Sun, William L. Ries, L. Lyndon Key, Martha Hardaway, Su Yang   +4 more
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Regulation of Tyrosine Kinases by Tyrosine Phosphorylation [PDF]

, 1991
Protein kinases can be classified according to whether they phosphorylate phenolic (tyrosine) or aliphatic (serine and threonine) hydroxyl groups (Hunter and Cooper, 1985). Although there are now a few examples of kinases that seemingly break the rule (Howell et al., 1990), most tyrosine kinases differ from the serine/threonine kinases in their primary
Alasdair MacAuley, Andrius Kazlauskas, Jonathan A. Cooper   +2 more
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Receptor Tyrosine Kinase Inhibitors

2015
Receptor tyrosine kinases (RTKs) are a diverse group of transmembrane proteins involved in signal transduction. Their function in many cell types is to drive a wide variety of cellular functions, including growth, differentiation and angiogenesis, by transducing growth factor signals from the external milieu to intracellular processes. In malignancies,
Antony M. Latham, Jayakanth Kankanala, Sreenivasan Ponnambalam   +2 more
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Protein tyrosine kinases and cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1997
4. Tyrosine kinase activation by mutation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . F222 4.1. BCR–ABL and human leukemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . F222 4.2. TEL–ABL and human leukemia . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . F224 4.3.
Brian J. Druker, Kathryn S. Kolibaba
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Oncogenic protein tyrosine kinases

Cellular and Molecular Life Sciences, 2004
Tyrosine kinases (TKs) and related molecules comprise over 100 different genes. Approximately two-thirds represent receptor TKs, the other third being non receptor TKs. TKs regulate important cellular signalling, from the transduction of extracellular signals to the regulation of key biological processes such as cell proliferation and apoptosis [1, 2].
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Antiangiogenic Drugs and Tyrosine Kinases

Anti-Cancer Agents in Medicinal Chemistry, 2008
Various cancer types have different molecular and biological strategies for vascularization: neoangiogenesis, postnatal vasculogenesis, glomeruloid angiogenesis, intussusceptive microvascular growth, vessel cooption and vascular mimicry. The majority is still relatively obscure, which limits the development of more successful antivascular agents. It is
Balazs Dome, József Tímár
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Receptor tyrosine kinases and their targets

Current Opinion in Genetics & Development, 1994
One of the ways in which higher eukaryotes receive messages from the environment is via cell surface receptor tyrosine kinases. These are transmembrane proteins with an extracellular binding domain that specifies the growth factor with which it will interact, and an intracellular domain that encodes the tyrosine kinase.
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Study of Tyrosine Kinases and Protein Tyrosine Phosphorylation

2004
In recent years, our increased understanding of the complex signal transduction mechanisms that regulate cellular function has fueled huge advances in all aspects of biomedical science and cell biology. Platelet and megakaryocyte function is no exception to this. In the last 10 yr our understanding of the receptor biochemistry and the systems that they
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Abl tyrosine protein kinase

Seminars in Immunology, 1995
Mammalian c-Abl belongs to an evolutionary conserved family of non-receptor tyrosine kinases. It is distributed both in the cytoplasm in association with F-actin, and in the nucleus where it binds chromatin. The normal function of c-Abl is poorly understood. Nevertheless, there has been rapid progress in the characterization of the structural features,
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Tyrosine kinase inhibitors and the thyroid

Best Practice & Research Clinical Endocrinology & Metabolism, 2009
Protein tyrosine kinase inhibitors (TKIs) have emerged as significant targets for novel cancer therapies. For patients with differentiated or medullary carcinomas unresponsive to conventional treatments, multiple novel therapies primarily targeting angiogenesis have entered clinical trials.
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