Results 241 to 250 of about 519,424 (350)

Correction: Receptor tyrosine kinase inhibitor sunitinib as novel immunotherapy to inhibit myeloid-derived suppressor cells for treatment of endometriosis. [PDF]

Front Immunol
He Y, Hung SW, Liang B, Zhang R, Gao Y, Chu CY, Zhang T, Xu H, Chung JPW, Wang CC.   +9 more
europepmc   +1 more source

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

Advanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

ZNF529 up-regulation speeds up progression and induces tyrosine kinase inhibitor resistance in hepatocellular carcinoma. [PDF]

J Gastrointest Oncol
Qin K, Zhou SS, Li JD, Qin DY, Zeng DT, Huang WY, Huang ZG, Yao GP, Chen YZ, Yin BT, Li FX, Wang L, Chen G, He RQ.   +13 more
europepmc   +1 more source

Multi-tyrosine kinase inhibitors in paediatric soft tissue sarcoma – A review [PDF]

Kim P.J. Schellekens, Andrea Ferrari, Michael T. Meister, C. Michel Zwaan, Susanne A. Gatz, Max M. van Noesel, Michela Casanova, Reineke A. Schoot   +7 more
openalex   +1 more source

OTUD6A in Airway Epithelial Cells Exacerbates Allergic Asthma by Promoting Airway Inflammation and Airway Remodeling Through Deubiquitination of hResistin/mRELMα

Advanced Science, EarlyView.
This study elucidates a novel mechanistic role of the deubiquitinase OTUD6A in asthma pathogenesis, uncovering its regulatory function in airway inflammation and airway remodeling through the stabilization of hResistin/mRELMα. This study offers a novel regulatory axis (OTUD6A‐hResistin/mRELMα) in asthma pathogenesis and OTUD6A inhibition as a potential
Weiting Pan, Xinru Xi, Wei Dai, Tingfang Xiao, Yeqing Chen, Xuanyu Chen, Xiangting Ge, Chengguang Zhao, Hui Zhang, Yali Zhang, Weixi Zhang   +10 more
wiley   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma. [PDF]

Int J Cancer
Zhao L, Cheng J, Zheng Y, Wu J, Fan J, Sun H, Gao C.   +6 more
europepmc   +1 more source

Inhibition of tumor–microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain [PDF]

, 2018
Grither, Whitney R., Longmore, Gregory D.   +1 more
core   +1 more source

Alpha-fetoprotein response predicts treatment outcomes in patients with unresectable hepatocellular carcinoma receiving immune checkpoint inhibitors with or without tyrosine kinase inhibitors or locoregional therapies.

, 2021
Wei‐Fan Hsu, Hung‐Wei Wang, Cheng‐Kuo Chen, Hung‐Chun Lai, Po‐Heng Chuang, Mu‐Hung Tsai, Wen‐Pang Su, Hung‐Yao Chen, Chia‐Sheng Chu, Jen‐Wei Chou, Sheng‐Hung Chen, Tsung-Yu Tsai, Wang‐De Hsiao, Chi‐Chen Lin, Guan‐Tarn Huang, Ming‐Tsan Lin, Cheng‐Yuan Peng   +16 more
openalex   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source

Jiedu Xiaozhen Granules for Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-Mediated Skin Toxicity: Protocol for a Randomized Controlled Trial.

JMIR Res Protoc
Hao S, Li X, Hao S, Zhang X, Qi X, Jin G, Shen F, Liu L.   +7 more
europepmc   +1 more source