Results 261 to 270 of about 326,057 (302)
Some of the next articles are maybe not open access.
Tyrosine Kinase Inhibitors and Cancer Therapy
Clinical Biochemistry, 2004Cancer is the second leading cause of death in the western world. Despite advances in diagnosis and treatment, overall survival of patients remains poor. Scientific advances in recent years have enhanced our understanding of the biology of cancer. Human protein tyrosine kinases (PTKs) play a central role in human carcinogenesis and have emerged as the ...
Srinivasan, Madhusudan +1 more
openaire +3 more sources
Bulletin du cancer, 2012
Membrane receptors with tyrosine kinase activity and cytoplasmic tyrosine kinases have emerged as important potential targets in oncology. Starting from basic structures such as anilino-quinazoline, numerous compounds have been synthesised, with the help of tyrosine kinase crystallography, which has allowed to optimise protein-ligand interactions.
+5 more sources
Membrane receptors with tyrosine kinase activity and cytoplasmic tyrosine kinases have emerged as important potential targets in oncology. Starting from basic structures such as anilino-quinazoline, numerous compounds have been synthesised, with the help of tyrosine kinase crystallography, which has allowed to optimise protein-ligand interactions.
+5 more sources
Neoadjuvant Tyrosine Kinase Inhibitors
Thoracic Surgery ClinicsNeoadjuvant tyrosine kinase inhibitor (TKI) therapy has appeal given the potential for early systemic disease control and tumor downstaging prior to surgery. Until recently, data has have come from smaller series with outcomes from larger trials, including NeoADAURA, ALNEO, and NAUTIKA1, reporting early results. Neoadjuvant use of TKI has been shown to
Gavitt A, Woodard +2 more
openaire +2 more sources
Tyrosine kinase inhibitors and the thyroid
Best Practice & Research Clinical Endocrinology & Metabolism, 2009Protein tyrosine kinase inhibitors (TKIs) have emerged as significant targets for novel cancer therapies. For patients with differentiated or medullary carcinomas unresponsive to conventional treatments, multiple novel therapies primarily targeting angiogenesis have entered clinical trials.
openaire +2 more sources
Receptor tyrosine kinase inhibitors in cancer
Cellular and Molecular Life Sciences, 2023Targeted therapy is a new cancer treatment approach, involving drugs that particularly target specific proteins in cancer cells, such as receptor tyrosine kinases (RTKs) which are involved in promoting growth and proliferation, Therefore inhibiting these proteins could impede cancer progression.
Nasim, Ebrahimi +11 more
openaire +2 more sources
Are catechins natural tyrosine kinase inhibitors?
Drug News & Perspectives, 2002Enhanced activity of tyrosine kinase receptors (RTKs) has been implicated as a contributing factor in the development of malignant and nonmalignant proliferative diseases such as cancer and atherosclerosis. Several growth factors traducing mitogenic signals through RTKs are implicated in the development of tumor and cardiovascular diseases.
Agapios, Sachinidis, Jurgen, Hescheler
openaire +2 more sources
Inhibitors of the insulin receptor tyrosine kinase
Pharmacology & Therapeutics, 1994Insulin is a polypeptide hormone consisting of 51 amino acids. Insulin promotes a variety of anabolic enzymatic pathways and inhibits many catabolic enzymatic pathways involved in energy storage, as well as in synthesis of structural tissue proteins.
P R, Srinivas, G, Grunberger
openaire +2 more sources
Arrhythmic Complications of Tyrosine Kinase Inhibitors
Future Cardiology, 2015Division of Cardiovascular Medicine, University of South Florida, Morsani College of Medicine, 2 Tampa General Circle, Tampa, FL 33606, USA Department of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA *Author for correspondence: mfradley@health.usf ...
Michael G, Fradley +1 more
openaire +2 more sources
Tyrosine kinase inhibitor induced pancreatitis
Journal of Oncology Pharmacy Practice, 2012Sorafenib and sunitinib are oral tyrosine kinase inhibitors, commonly used in the treatment of metastatic renal cell carcinoma. Known adverse events associated with tyrosine kinase inhibitors include hypertension and palmarplantar erythrodysesthesia. We report two cases of acute pancreatitis associated with tyrosine kinase inhibitors.
Adrienne, Sevin +2 more
openaire +2 more sources
2016
Breast cancer is the most common cancer in women worldwide. Although various subgroups are defined according to the expression of hormones and ErbB family receptors, it is well known that this disease is more heterogeneous than its classification system suggests.
Burcu Cakar, Erdem Göker
openaire +1 more source
Breast cancer is the most common cancer in women worldwide. Although various subgroups are defined according to the expression of hormones and ErbB family receptors, it is well known that this disease is more heterogeneous than its classification system suggests.
Burcu Cakar, Erdem Göker
openaire +1 more source