Results 191 to 200 of about 269,227 (256)

Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

Animal Models and Experimental Medicine, EarlyView.
We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin, Zichu Fu, Xuanxuan Zou, Senmao Chai, Jingjing Weng, Puqing Wang, Xiaodong Sun, Ming Sang   +7 more
wiley   +1 more source

Current and future landscape of Bruton tyrosine kinase inhibitors in allergy. [PDF]

J Allergy Clin Immunol
Lin EV, Arce B, Alvarez-Arango S, Dispenza MC.   +3 more
europepmc   +1 more source

SnRNA‐seq reveals cellular heterogeneity and proliferation mechanisms in limb venous malformations

Animal Models and Experimental Medicine, EarlyView.
To dissect the cellular heterogeneity and invasive mechanisms of limb venous malformations (VMs), this study first obtained tissue samples from four patients with VMs and four normal controls (NC). Single‐nucleus suspension was prepared, followed by transcriptome library construction and sequencing. After pretreatment, quality control, standardization,
Junjie Lin, Tingting Liu, Bin Fang, Xiaojuan Feng, Wenting Jiao, Changkuan Chen, Yaqing Ding, Gaozan Zhu, Wenqiu Wang, Wenbo Liu, Yuanqi Li, Shoufu Hou, Jianshe Wei, Junbo Qiao   +13 more
wiley   +1 more source

Efficacy and safety of tyrosine kinase inhibitors in advanced hepatocellular carcinoma patients with Child-Pugh A and B cirrhosis: a meta-analysis. [PDF]

Front Pharmacol
Liu X, Li J, Li M, Xiang B.
europepmc   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Characterizing P-glycoprotein and Breast Cancer Resistance Protein interactions of asciminib among other tyrosine kinase inhibitors used in chronic myeloid leukemia. [PDF]

Cancer Chemother Pharmacol
Verhagen NE, Touw DCW, van den Heuvel JJMW, van den Broek PH, Blijlevens NMA, Janssen JJWM, Koenderink JB, Russel FGM.   +7 more
europepmc   +1 more source

Tyrosine-kinase inhibitors for lung or breast cancer and drug-drug interactions: a clinical guide. [PDF]

Oncol Rev
Santamaria F, Roberto M, Maltese G, Nicolella F, Torchia A, Buccilli D, Di Civita MA, Giancontieri P, Marinelli D, Cirillo A, Bianco V, Verrico M, Botticelli A, Santini D.   +13 more
europepmc   +1 more source

AXL-SHC1 signaling axis mediates adaptive resistance to HER2-targeted tyrosine kinase inhibitors in HER2-aberrant lung and gastric cancers. [PDF]

NPJ Precis Oncol
Ishida M, Yamada T, Katayama Y, Kawachi H, Sawada R, Nakamura R, Hirai S, Matsui Y, Morimoto K, Onoi K, Nakamura-Sasada A, Horinaka M, Sakai T, Sakakida T, Doi T, Yasumoto K, Goto Y, Furuya N, Taniguchi H, Ogino H, Takayuki N, Chihara Y, Fukuda K, Taniguchi H, Uehara H, Yano S, Tokuda S, Takayama K.   +27 more
europepmc   +1 more source

The resistance landscape of EGFR tyrosine kinase inhibitors in advanced non-small cell lung cancer: molecular mechanisms and novel therapeutic strategies. [PDF]

Transl Lung Cancer Res
Liu S, Zhou L, He Y, Liu Q, Tang Y, Liu Z, Zeng X, Li J.   +7 more
europepmc   +1 more source

<i>BCR::ABL1</i> Mutational Profiling in US Patients With Chronic-phase Chronic Myeloid Leukemia on Tyrosine Kinase Inhibitors. [PDF]

Cancer Diagn Progn
Haddad FG, Jabbour EJ, Gutkin SW, Pathak AK, Zhai Y, Kantarjian HM.   +5 more
europepmc   +1 more source