Results 201 to 210 of about 857,410 (384)
Advanced Science, EarlyView.Identifying biomarkers associated with PTC, particularly those related to PTMC progression, is crucial for precise risk stratification and treatment planning. This study utilized single‐cell RNA sequencing on 19 surgical tissue specimens, confirmed PROS1/MERTK axis as a critical component of the cellular microenvironment and a key regulatory mechanism ...
Wenqian Zhang +11 more
wiley +1 more source
Tyrosine Kinase Inhibitor–associated Fibrothorax [PDF]
American Journal of Respiratory and Critical Care Medicine, 2019 Jorge E. Cortes +5 more
openaire +3 more sources
Inhibition of Experimental Autoimmune Encephalomyelitis by a Tyrosine Kinase Inhibitor [PDF]
, 1999 Gabriela Constantin +3 more
openalex +1 more source
Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization
Advanced Science, EarlyView.This study identified a natural compound, isoquercitrin, which significantly alleviated kidney inflammation and fibrosis by inhibiting STAT3 activity. Isoquercitrin forms a strong, noncovalent bond that directly binds to STAT3. Isoquercitrin binds to the pY+1 pocket of the SH2 domain of STAT3 via hydrogen bonding with Ser668, Gln635, and Gln633 ...
Chen Xuan +12 more
wiley +1 more source
Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture
Advanced Science, EarlyView.This study uses experiments and biophysical modeling to examine the response and adaptation of cells to nanoscale topography of surfaces. It is shown that cytoskeletal assembly and nuclear localization of transcription regulatory factors such as yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) can be tuned by ...
Emmet A. Francis +7 more
wiley +1 more source
Synergistic activation of guinea‐pig cardiac cystic fibrosis transmembrane conductance regulator by the tyrosine kinase inhibitor genistein and cAMP [PDF]
, 1997 Lesya M. Shuba, Terence F. McDonald
openalex +1 more source
Advanced Science, EarlyView.MP3 tumor cells, a specific subpopulation of tumor cells in D‐TGCT, regulated the differentiation of CD34+ Fbs into MMP3+ Fbs and APOE+ Fbs through COL6A3 − (ITGAV + ITGB8) interaction. APOE+ Fbs activated IL‐1B+CCL20+ Mφs through the CXCL12/CXCR4 axis. IL‐1B+CCL20+ Mφs and MMP3+ Fbs participated in the local invasion of D‐TGCT.
Yubin Xie +15 more
wiley +1 more source