Results 231 to 240 of about 871,767 (407)

Dose Optimization of Tyrosine Kinase Inhibitors for Chronic Myeloid Leukemia. [PDF]

Clin Pharmacol
Chen J, Zhu Y, Zhao Y, Guo N, Yao Y, Luo X, Huang L.   +6 more
europepmc   +1 more source

D‐glucuronyl C5‐Epimerase Binds to EGFR to Suppress Kidney Fibrosis

Advanced Science, EarlyView.
Glucuronyl C5‐epimerase (Hsepi, gene name Glce) is a key enzyme catalyzing heparan sulfate (HS) chain biosynthesis in HS proteoglycans, which are ubiquitously expressed on cell membranes. In normal renal tubular cells, Glce binds to the intracellular domains of EGFR, maintaining stable and orderly EGFR phosphorylation.
Xiaoqi Jing, Jun Wu, Jingru Ning, Xiaoyu Ding, Zhenyun Du, Xiaojiang Wang, Lulin Huang, Ran Wang, Changlin Mei, Kan Ding   +9 more
wiley   +1 more source

Hypoxia Induces Transcription of the Plasminogen Activator Inhibitor-1 Gene Through Genistein-Sensitive Tyrosine Kinase Pathways in Vascular Endothelial Cells [PDF]

, 2000
Tsuyoshi Uchiyama, Masahiko Kurabayashi, Yoshio Ohyama, Toshihiro Utsugi, Nobuhiro Akuzawa, Mahito Sato, Shouichi Tomono, Shoji Kawazu, Ryozo Nagai   +8 more
openalex   +1 more source

Bibliometric analysis of hepatocellular carcinoma and tyrosine kinase inhibitors. [PDF]

Medicine (Baltimore)
Wu W, Mao H, Song J, Yang F.
europepmc   +1 more source

Phosphorylation‐Dependent Stabilization of Collaborator of ARF (CARF) Suppresses Lymphoma Cell Proliferation

Advanced Science, EarlyView.
This study revealed that oncogene Collaborator of ARF (CARF) is closely related to B‐cell lymphoma tumorigenesis, and shares a conserved mechanism regulating protein stability with Arabidopsis Kip‐Related Protein6 (KRP6) through casein kinase 1‐mediated phosphorylation. Reduced phosphorylation led to the enhanced protein stability of CARF, resulting in
Li Qu, Zhuang Wei, Shuting Zhou, Xiaofan Zhang, Wenjun Zhang, Aibin Liang, Zhe Wang, Hongwei Xue   +7 more
wiley   +1 more source

Semicochliodinol A and B: Inhibitors of HIV-1 Protease and EGF-R Protein Tyrosine Kinase Related to Asterriquinones Produced by the Fungus Chrysosporium merdarium.

, 1997
Andreas Fredenhagen, Frank Petersen, Marina Tintelnot‐Blomley, Johannes Rösel, Helmut Mett, Paul Hug   +5 more
openalex   +2 more sources

The tyrosine kinase inhibitor STI571, like interferon-α, preferentially reduces the capacity for amplification of granulocyte-macrophage progenitors from patients with chronic myeloid leukemia [PDF]

, 2000
Stephen B Marley, Michael W. Deininger, Richard J. Davidson, John M. Goldman, Myrtle Y. Gordon   +4 more
openalex   +1 more source

Exploring research frontiers and emerging trends of tyrosine kinase inhibitors in the treatment of colorectal cancer. [PDF]

BMC Cancer
Li X, Chen Z, Yin J, Shen X, Li H.
europepmc   +1 more source

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

Advanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao, Yuan Fei Li, Fu Kang Yuan, Meng Lu Zhao, Ya Wen Han, Jia Xin Wang, Qi Yang, Han Ying Ye, Yu Cheng Lu, Shao Chin Lee   +9 more
wiley   +1 more source

Effects of protein tyrosine kinase inhibitors on voltage‐operated calcium channel currents in vascular smooth muscle cells and pp60^c‐src kinase activity [PDF]

, 2000
S. Wijetunge, Joanne Lymn, Alun D. Hughes   +2 more
openalex   +1 more source