Results 261 to 270 of about 871,767 (407)

Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition

Advanced Science, EarlyView.
Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu, Zhihuang Zheng, Marleen Silke Oswald, Guozhe Cheng, Jun Liu, Qidi Zhai, Ute Kruegel, Michael Schaefer, Holger Gerhardt, Nicole Endlich, Maik Gollasch, Stefan Simm, Dmitry Tsvetkov   +12 more
wiley   +1 more source

The Tyrosine Kinase Hck Is an Inhibitor of HIV-1 Replication Counteracted by the Viral Vif Protein [PDF]

, 2001
Ghérici Hassaı̈ne, M Courcoul, Gilles Bessou, Yves Barthalay, Christophe Picard, Daniel Olive, Yves Collette, Robert Vigne, Étienne Decroly   +8 more
openalex   +1 more source

Multimodal prediction of tyrosine kinase inhibitors therapy outcomes in advanced EGFR-mutated NSCLC patients. [PDF]

J Transl Med
Chai X, Li H, Yang M, Zeng J, Chen G, Li Y, Wang W, Liu Z, Li K, Zhang T, Wang S, Che N.   +11 more
europepmc   +1 more source

Targeting IGF1R Overcomes Armored and Cold Tumor Microenvironment and Boosts Immune Checkpoint Blockade in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
IGF1R is highly expressed in the armored & cold tumors, and collagen mediates IGF1R at the transcriptional and post‐translational levels to promote TNBC cell invasion and immune escape and to stabilize its own structure by interacting with the collagen receptor DDR1.
Mengyun Wan, Jie Mei, Yun Cai, Ji Zhou, Ningyi Xue, Ying Jiang, Yan Zhang, Jingjing Huang, Yichao Zhu   +8 more
wiley   +1 more source

The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls [PDF]

, 2001
Uwe‐Karsten Hanisch, Marco Prinz, Klemens Angstwurm, Karl Georg Häusler, Oliver Kann, Helmut Kettenmann, Joerg R. Weber   +6 more
openalex   +1 more source

Advancing endometrial cancer treatment: exploring immunotherapy and tyrosine kinase inhibitors through clinical cases. [PDF]

Drugs Context
Salutari V.
europepmc   +1 more source

Aligned Conductive Magnetic Nanofibers with Directional Magnetic Field Stimulation Promotes Peripheral Nerve Regeneration

Advanced Science, EarlyView.
Peripheral nerve injury necessitates alternatives to autografts. This study combines magnetic nanoparticles, oriented PCL fibers, and Ppy to create a conductive, magnetically active scaffold. In vitro and in vivo experiments demonstrated enhanced downstream pathways of calcium signaling, as revealed by transcriptome analysis.
Zheyuan Fan, Wei Yu, Xinggui Wen, Xiangdong Ding, Xiang Li   +4 more
wiley   +1 more source

THE EFFECT OF A TYROSINE KINASE INHIBITOR ON LPS INDUCED MORTALITY AND MEDIATOR PRODUCTION IN A NEONATAL RAT MODEL.

, 1996
Jennifer R. Cochran, H. Chen, Giuseppe Teti, James A. Cook   +3 more
openalex   +1 more source

3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors Block Calcium-dependent Tyrosine Kinase Pyk2 Activation by Angiotensin II in Vascular Endothelial Cells [PDF]

, 2001
Kumi Satoh, Kazuo Ichihara, Erwin J. Landon, Tadashi Inagami, Hua Tang   +4 more
openalex   +1 more source

Impact of Tyrosine Kinase Inhibitors on Thyroid Function in Chronic Myeloid Leukemia: A Systematic Review. [PDF]

Cureus
Sardarova N, Patel T, Abugoukh TM, Kim D, Yousuf S, Hammoude M.   +5 more
europepmc   +1 more source