Results 31 to 40 of about 443,809 (299)

Nanomedicine of tyrosine kinase inhibitors

Theranostics, 2021
Recent progress in nanomedicine and targeted therapy brings new breeze into the field of therapeutic applications of tyrosine kinase inhibitors (TKIs). These drugs are known for many side effects due to non-targeted mechanism of action that negatively impact quality of patients' lives or that are responsible for failure of the drugs in clinical trials.
Šmídová, Veronika, Michálek, Petr, Goliášová, Zita, Eckschlager, Tomáš, Hodek, Petr, Adam, Vojtěch, Heger, Zbyněk   +6 more
openaire   +3 more sources

Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus [PDF]

, 2008
We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of α7 nAChR. In the present studies, mechanisms underlying the acute and chronic
Abel, Arendt, Atack, Bain, Bear, Blanquet, Bliss, Blitzer, Blitzer, Bogan, Casey, Charpantier, Cho, Dajas-Bailador, Davies, Davis, Decker, Dhavan, Dominguez del Toro, English, Faghih, Fujii, Giovannini, Gray, Hope, Huang, Huang, Hunter, Hurst, Ji, Jones, Kawakami, Kelly, Kihara, Klein, Krause, Le Novere, Levin, Li, Liston, Lu, Man, Mann, Marrero, Matsuyama, Matthies, Meriane, Opazo, O’Dell, Peavy, Picciotto, Polesskaya, Polesskaya, Radcliffe, Roberson, Rush, Salazar, Sanna, Sanna, Santos, Seguela, Sharifzadeh, Sharifzadeh, Sharma, Shaw, Shaw, Sweatt, Takada-Takatori, Tominaga-Yoshino, Wada, Wang, Wang, Welsby, Welsby, Whitehouse, Woo, Wu, Yang, Ying, Yu, Zhang, Zwart   +81 more
core   +1 more source

Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. [PDF]

, 2014
Btk and Etk/BMX are Tec-family non-receptor tyrosine kinases. Btk has previously been reported to be expressed primarily in B cells and has an important role in immune responses and B-cell malignancies.
Bhardwaj, G, Changou, C, Chintapalli, S, Evans, CP, Guo, W, Kumaresan, P, Kung, H-J, Lam, KS, Liu, R, Ma, A-H, Mazloom, A, Patterson, R, Sanchez, E, Xiao, K, Xiao, W, Yang, JC, Yeh, C-T   +16 more
core   +2 more sources

New targets for resolution of airway remodeling in obstructive lung diseases. [PDF]

, 2018
Airway remodeling (AR) is a progressive pathological feature of the obstructive lung diseases, including asthma and chronic obstructive pulmonary disease (COPD).
Deshpande, Deepak A., Nayak, Ajay P., Penn, Raymond B   +2 more
core   +2 more sources

Hepatocyte growth factor, a key tumor-promoting factor in the tumor microenvironment [PDF]

, 2017
The tumor microenvironment plays a key role in tumor development and progression. Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which promote growth, survival and metastatic spread of cancer cells.
Galemmo, Robert, Janetka, James, Klampfer, Lidija, Owusu, Benjamin Yaw   +3 more
core   +2 more sources

Skin Toxicities Induced by Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and their Influence on Treatment Adjustments in Lung Cancer Patients

Acta Dermato-Venereologica
Skin toxicities caused by epidermal growth factor receptor tyrosine kinase inhibitors can affect patient quality of life and lead to treatment adjustments, including dose reduction or discontinuation.
Ji Su Lee, Jimin Woo, Tae Min Kim, Namkyu Kim, Bhumsuk Keam, Seong Jin Jo   +5 more
doaj   +1 more source

Interstitial Lung Disease Induced by Crizotinib in Non-Small-Cell Lung Cancer

Acta Médica Portuguesa, 2019
The treatment of advanced non-small-cell lung cancer shifted with the development of molecular-targeted therapies, like the tyrosine kinase inhibitors.
Andreia Tereso, Luís Carreto, Manuela Baptista, Maria Amélia Almeida   +3 more
doaj   +1 more source

Evidence of the presence of calcium/calmodulin-dependent protein kinase IV in human sperm and its involvement in motility regulation [PDF]

, 2005
The mechanisms involved in the regulation of mammalian sperm motility are not well understood. Calcium ions (Ca(2+)) have been suggested to play a key role in the maintenance of motility; nevertheless, how Ca(2+) modulates this process has not yet been ...
Buffone, Mariano Gabriel, Chertihin, Olga, Herr, John C,, Jha, Kula N., Marin Briggiler, Clara Isabel, Vazquez, Monica Hebe, Visconti, Pablo E.   +6 more
core   +1 more source

Therapeutic choices in patients with Ph-Positive chronic myelogenous leukemia in Mexico in the era of tyrosine kinase inhibitors: stem cell transplantation or tyrosine kinase inhibitors? Fifteen years later

Revista de Investigación Clínica
Background: Chronic myelogenous leukemia is a neoplastic proliferation of the granulocytic series. In Mexico, chronic myelogenous leukemia accounts for approximately 10% of all leukemias.
Max Robles-Nasta, Daniela Sánchez-Bonilla, Moises M. Gallardo-Pérez, Edgar J. Hernández-Flores, Merittzel A. Montes-Robles, María de L. Pastelín-Martínez, Juan C. Olivares-Gazca, Guillermo J. Ruiz-Delgado, Guillermo J. Ruiz-Argüelles   +8 more
doaj   +1 more source

Nilotinib-Associated Destructive Thyroiditis

Case Reports in Endocrinology, 2015
Protein tyrosine kinase inhibitors are currently an important drug class in the treatment of leukemia. They represent targeted cancer therapy and have become the treatment of choice in chronic myeloid leukemia.
Suhalia Bakerywala, Monica D. Schwarcz, Michael D. Goldberg, Guy Valiquette, Irene A. Weiss   +4 more
doaj   +1 more source