Results 131 to 140 of about 4,013,335 (305)
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
A U-Net Architecture for Inpainting Lightstage Normal Maps
ComputersIn this paper, we investigate the inpainting of normal maps that were captured from a lightstage. Occlusion of parts of the face during performance capture can be caused by the movement of, e.g., arms, hair, or props.
Hancheng Zuo, Bernard Tiddeman
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Geocarto InternationalForest Canopy Closure (CC) is vital for assessing forest ecosystems. This study integrates multispectral imagery with enhanced U-Net models (U-Net, U-Net++, U-Net3+) to achieve cost-effective large-scale CC estimation.
Lei Chen +5 more
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Deep learning-enabled generative acceleration for topology-optimized structures in 2D and 3D domain
Discover Artificial IntelligenceLatest research explored into how Deep Learning (DL) can be used to accelerate topology optimization while reducing processing costs. Topology optimization, relying on finite element analysis (FEA) and iterative solvers, typically incurs substantial ...
S Kanmani, M. Murali
doaj +1 more source
2025 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW)Published in CVPR Workshops (CVMI), 2025. Project page/code/models/dataset: $\href{https://slavkoprytula.github.io/IAUNet/}{\text{this https URL}}$
Yaroslav Prytula +3 more
openaire +3 more sources
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source