Results 111 to 120 of about 5,768,655 (280)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Enhanced glioma semantic segmentation using U-net and pre-trained backbone U-net architectures
Scientific ReportsGliomas are known to have different sub-regions within the tumor, including the edema, necrotic, and active tumor regions. Segmenting of these regions is very important for glioma treatment decisions and management.
Amir Khorasani
doaj +1 more source
LU-NET: An Improved U-Net for Ventricular Segmentation
IEEE Access, 2019 In order to solve the problem of low accuracy of the U-Net in cardiac ventricular segmentation, we propose an improved U-net named LU-Net by the following three methods.
Jun Zhang +5 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Recurrent U-Net for Resource-Constrained Segmentation [PDF]
, 2019 State-of-the-art segmentation methods rely on very deep networks that are not always easy to train without very large training datasets and tend to be relatively slow to run on standard GPUs.
Fua, Pascal +9 more
core +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
CoRR, 2018 We design a new connectivity pattern for the U-Net architecture. Given several stacked U-Nets, we couple each U-Net pair through the connections of their semantic blocks, resulting in the coupled U-Nets (CU-Net). The coupling connections could make the information flow more efficiently across U-Nets.
Zhiqiang Tang 0001 +4 more
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A deep learning aided bone marrow segmentation of quantitative fat MRI for myelofibrosis patients
Frontiers in OncologyPurposeTo automate bone marrow segmentation within pelvic bones in quantitative fat MRI of myelofibrosis (MF) patients using deep-learning (DL) U-Net models.MethodsAutomated segmentation of bone marrow (BM) was evaluated for four U-Net models: 2D U-Net ...
Humera Tariq +7 more
doaj +1 more source