Results 111 to 120 of about 4,013,335 (305)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

A Novel Deep Learning Model for Pancreas Segmentation: Pascal U-Net

Inteligencia Artificial
A robust and reliable automated organ segmentation from abdomen images is a crucial problem in both quantitative imaging analysis and computer aided diagnosis.
Ender Kurnaz, Rahime Ceylan, Mustafa Alper Bozkurt, Hakan Cebeci, Mustafa Koplay   +4 more
doaj  

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Generalized U-Net for automatic liver segmentation and R2* estimation for assessment of iron overload using MRI

BMC Medical Imaging
Background Although R2*-MRI is extensively validated for assessing liver iron concentration (LIC), techniques for robust and automatic liver extraction remain underdeveloped, limiting clinical workflow and adoption for automated LIC reporting. Hence this
Utsav Shrestha, Zachary R. Abramson, Stephan Kannengiesser, Xiaodong Zhong, Cara E. Morin, Aaryani Tipirneni-Sajja   +5 more
doaj   +1 more source

Injecting Hierarchy with U-Net Transformers

CoRR, 2019
The Transformer architecture has become increasingly popular over the past two years, owing to its impressive performance on a number of natural language processing (NLP) tasks. However, all Transformer computations occur at the level of word representations and therefore, it may be argued that Transformer models do not explicitly attempt to learn ...
David Donahue, Vladislav Lialin, Anna Rumshisky   +2 more
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

A Comparative Analysis of Deep-Learning-Based Speech Enhancement Models: Assessing Biometric Speaker Verification in Real-World Noisy Environments

Big Data and Cognitive Computing
Speech enhancement through denoising is essential for maintaining signal intelligibility and quality in biometric speaker verification pipelines that operate in acoustically adverse conditions.
Md Jahangir Alam Khondkar, Ajan Ahmed, Stephanie Schuckers, Masudul H. Imtiaz   +3 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A dynamic petri net model for iterative and interactive distributed multimedia presentation [PDF]

, 2005
Object Composition Petri Nets (OCPN), Priority Petri Nets (P-Net), Dynamic OCPN (DOCPN) and Enhanced P-Nets (EP-Net) have extended the original Petri Net to achieve the modeling of media synchronization and asynchronous user interactions during ...
Guan, SU, Tan, WK
core