Results 91 to 100 of about 4,013,335 (305)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Enhanced glaucoma detection using U-Net and U-Net+ architectures using deep learning techniques
Photodiagnosis and Photodynamic TherapyThis study compares multiple image processing and deep learning methods to demonstrate an enhanced approach to glaucoma diagnosis. The approach focuses on noise reduction using median filtering and optic disc segmentation utilizing the U-Net and U-Net ...
B.P. Pradeep kumar +2 more
doaj +1 more source
تشخیص فروچالهها و زمینلغزشها با استفاده از روشهای یادگیری عمیق و تصاویر پهپادی [PDF]
Muhandisī va mudirīyyat-i ābkhīzمقدمه زمینلغزشها و فروچالهها به زیرساختهای اجتماعی، اقتصادی و طبیعی آسیب میزنند. این فرایندها تأثیرات مستقیم و غیرمستقیم بر زیرساختهای مهم، از جمله مناطق مسکونی دارند و بر تغییر کاربری اراضی و مهاجرت از روستا به شهر تأثیرگذارند.
نرگس کریمینژاد +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Functorial Semantics for Petri Nets under the Individual Token Philosophy [PDF]
, 1999 Although the algebraic semantics of place/transition Petri nets under the collective token philosophy has been fully explained in terms of (strictly) symmetric (strict) monoidal categories, the analogous construction under the individual token philosophy
Meseguer, J. +11 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Is Our Carbon Wallet Empty: The embodied carbon of the national infrastructure pipeline. A report by the Net Zero Infrastructure Industry Coalition [PDF]
, 2021 This report highlights the challenges the infrastructure sector faces in addressing the UK’s net-zero carbon commitment by 2050. Included is a manifesto for change, which will enable the infrastructure sector to measure, control and reduce carbon ...
Net Zero Infrastructure Industry Coalition
core
An experimental study of U-net variants on liver segmentation from CT scans
Journal of Intelligent SystemsThe liver, a complex and important organ in the human body, is crucial to many physiological processes. For the diagnosis and ongoing monitoring of a wide spectrum of liver diseases, an accurate segmentation of the liver from medical imaging is essential.
Halder Akash +4 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source