Results 81 to 90 of about 5,543,646 (278)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Injecting Hierarchy with U-Net Transformers
CoRR, 2019 The Transformer architecture has become increasingly popular over the past two years, owing to its impressive performance on a number of natural language processing (NLP) tasks. However, all Transformer computations occur at the level of word representations and therefore, it may be argued that Transformer models do not explicitly attempt to learn ...
David Donahue +2 more
openaire +2 more sources
Dense-U-net network structure.
A brain tumor magnetic resonance image processing algorithm can help doctors to diagnose and treat the patient’s condition, which has important application significance in clinical medicine. This paper proposes a network model based on the combination of
Xiaoli Yang (314226) +4 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Enhanced glaucoma detection using U-Net and U-Net+ architectures using deep learning techniques
Photodiagnosis and Photodynamic TherapyThis study compares multiple image processing and deep learning methods to demonstrate an enhanced approach to glaucoma diagnosis. The approach focuses on noise reduction using median filtering and optic disc segmentation utilizing the U-Net and U-Net ...
B.P. Pradeep kumar +2 more
doaj +1 more source
تشخیص فروچالهها و زمینلغزشها با استفاده از روشهای یادگیری عمیق و تصاویر پهپادی [PDF]
Muhandisī va mudirīyyat-i ābkhīzمقدمه زمینلغزشها و فروچالهها به زیرساختهای اجتماعی، اقتصادی و طبیعی آسیب میزنند. این فرایندها تأثیرات مستقیم و غیرمستقیم بر زیرساختهای مهم، از جمله مناطق مسکونی دارند و بر تغییر کاربری اراضی و مهاجرت از روستا به شهر تأثیرگذارند.
نرگس کریمینژاد +3 more
doaj +1 more source
Lost in the Vaso‐Occlusion: A Patient's Abdominal Pain Returns With a Vengeance
Pediatric Blood &Cancer, EarlyView.
Dunia Hatabah +5 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source