Results 121 to 130 of about 295,660 (323)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Perbandingan Model U-Net dan ELU-Net untuk Segmentasi Semantik Citra Medis Kanker Pankreas

Jurnal Nasional Teknik Elektro dan Teknologi Informasi
Analisis citra medis untuk melakukan segmentasi semantik menggunakan teknologi deep learning masif dikembangkan saat ini. Salah satu pengembangannya adalah arsitektur U-Net, yang dapat menghasilkan akurasi yang baik. Pengembangan dilanjutkan menghasilkan
Algi Fari Ramdhani, Yudi Widhiyasana, Setiadi Rachmat   +2 more
doaj   +1 more source

Landform detection on Mars using image segmentation with a u-net convolutional neural network architecture

, 2023
Florian Auer-Welsbach, Andreas Windisch, Giacomo Nodjoumi   +2 more
openalex   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

CU-Net: Coupled U-Nets

, 2018
We design a new connectivity pattern for the U-Net architecture. Given several stacked U-Nets, we couple each U-Net pair through the connections of their semantic blocks, resulting in the coupled U-Nets (CU-Net). The coupling connections could make the information flow more efficiently across U-Nets.
Tang, Zhiqiang, Peng, Xi, Geng, Shijie, Zhu, Yizhe, Metaxas, Dimitris N.   +4 more
openaire   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

RepFed-Net: privacy-preserving federated learning with reputation-aware aggregation for retinal vessel segmentation using enhanced U-Net [PDF]

A. V. V. M Sri, Mahesh Kumar Morampudi
openalex   +1 more source

MU Net: Ovarian Follicle Segmentation Using Modified U-Net Architecture

, 2022
Debasmita Saha, Ardhendu Mandal, Rinku Ghosh   +2 more
openalex   +1 more source