Results 81 to 90 of about 274,745 (274)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

MDU-Net: Multi-scale Densely Connected U-Net for biomedical image segmentation

, 2018
Radiologist is "doctor's doctor", biomedical image segmentation plays a central role in quantitative analysis, clinical diagnosis, and medical intervention.
Jin, Yuzhen, Xu, Jilan, Xu, Xiaowei, Zhang, Jiawei, Zhang, Yanchun   +4 more
core  

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Application of U-net models in estimating forest canopy closure based on multi-source remote sensing imagery

Geocarto International
Forest Canopy Closure (CC) is vital for assessing forest ecosystems. This study integrates multispectral imagery with enhanced U-Net models (U-Net, U-Net++, U-Net3+) to achieve cost-effective large-scale CC estimation.
Lei Chen, TingTing Yang, ZhiQiang Wu, XinLong Li, YanZhen Lin, Yi Lian   +5 more
doaj   +1 more source

Image Segmentation Based On U-Net and Adjusted U-Nets

Highlights in Science, Engineering and Technology
Image segmentation, the process of dividing an image into various areas is quite crucial recently. Numerous industries, including robotics, remote sensing, and medical imaging, have applications for this task. In recent years, deep learning techniques, especially U-shaped networks (U-nets), have shown remarkable success in solving image segmentation ...
openaire   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Leveraging U-Net and ASPP for effective fault detection in photovoltaic modules

Scientific Reports
The efficiency of photovoltaic (PV) systems is often compromised by undetected faults, exacerbated by the complexity of thermal imagery backgrounds. This study presents a novel deep-learning-based approach to enhance fault detection in PV systems by ...
Khalfalla Awedat, Masoud Alajmi, Mustafa Elfituri   +2 more
doaj   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

A U-Net Architecture for Inpainting Lightstage Normal Maps

Computers
In this paper, we investigate the inpainting of normal maps that were captured from a lightstage. Occlusion of parts of the face during performance capture can be caused by the movement of, e.g., arms, hair, or props.
Hancheng Zuo, Bernard Tiddeman
doaj   +1 more source