Results 121 to 130 of about 3,263,406 (307)

Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]

, 2009
Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE ...
Nakano, Yuko, Willem, Michael, Kudo, Takashi, Minagawa, Kazuyuki, Jiang, Jingwei, Okochi, Masayasu, Takemoto, Hiroshi, Hosono, Motoko, Nishimura, Masaki, Takeda, Masatoshi, Itoh, Naohiro, Nishigaki, Atsuko, Hasegawa, Hiroshi, Sakaguchi, Gaku, Kato, Akira, Haass, Christian, Tanaka, Toshihisa, Yanagida, Kanta, Mori, Kohji, Nakayama, Taisuke, Kikuchi, Jyunko, Dohi, Keiji, Takinami, Yoshihiko, Katoh, Takaaki, Nishitomi, Kouhei, Morihara, Takashi, Tagami, Shinji, Fukumori, Akio   +27 more
core   +1 more source

CADASIL – obraz zmian morfologicznych i ich patomechanizm

Aktualności Neurologiczne, 2011
CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) jest uogólnioną chorobą naczyń związaną z obecnością mutacji w umiejscowionym na chromosomie 19. genie NOTCH 3. Proces patologiczny w CADASIL-u uszkadza
Dorota Dziewulska
doaj  

Flash Assembloids: A Rapid Biofabrication of a Platform for Modeling Early Glioblastoma Invasion at the Glioblastoma–Brain Organoid Interfaces

Advanced Healthcare Materials, EarlyView.
This study presents a bioengineered assembloid (ASM) system combining glioblastoma (GBM) cells in oxidized alginate (OA) microgels with dorsal organoids (DOs). This model simulates brain tumor‐host interactions, revealing enhanced GBM invasion, altered gene expression, and aggressive infiltration patterns, demonstrating ASM as a valuable platform for ...
Chao Liang, Henry Robert Howard, Shihui Chen, Won‐Young Choi, Summer Cao, Arthur Chien, Kevin Zou, Michael Kassiou, Fabien Delerue, Ho Sang Jung, Yeonju Park, Young Mee Jung, Yong‐Dae Kwon, Karrie M. Kiang, Gilberto Ka‐Kit Leung, Ryohichi Sugimura, Ann‐Na Cho, Sang Jin Lee   +17 more
wiley   +1 more source

Therapeutic Extracellular Vesicles from Synovial Fibroblast‐Primed MSCs for Osteoarthritis Treatment

Advanced Healthcare Materials, EarlyView.
EVs derived from the microenvironment of SFs transferred MSCs (miSF‐MSC‐EVs) enhanced the expression of miRNAs that regulate cell migration, cell adhesion, and the TGF‐β signaling pathway, demonstrating superior anti‐inflammatory and cartilage regeneration effects compared to conventional MSC‐EVs.
Seo Jeong Kim, Ji Seob Kim, Min Hee Moon, Jae‐Hyeok Jang, In Sun Hwang, Byung‐Hyun Cha   +5 more
wiley   +1 more source

Experimental Investigation of the Influence of Notch Geometry on Impact Resistance of Al/Cu Bimetallic Sheets

Journal of Engineering
The impact resistance of bimetallic materials is a critical aspect of engineering, particularly in the aerospace and automotive industries. Notched geometries are often encountered in real-world scenarios due to manufacturing defects or intentional ...
Shadi B. Ahmed, Paiman S. Salih , Hameed D. Lafta   +2 more
doaj   +1 more source

Nanoplatforms for Sentinel and Tumor‐Draining Lymph Node Mapping: From Visualization to Pathway‐Informed Staging

Advanced Healthcare Materials, EarlyView.
Lymphotropic nanoplatforms integrate multimodal imaging with therapeutic guidance to map sentinel and tumor‐draining lymph nodes, revealing functional drainage, metastatic involvement, and nodal accessibility, while providing mechanistic insight to support precision surgical and therapeutic interventions.
Xu Chen, Nina Li, Meiyan Zou, Zihao Zhou, Rongwei Xu, Weiyao Feng, Xinyuan Zhao, Li Cui   +7 more
wiley   +1 more source

Application of the Theory of Critical Distances to the notch effect in expanded polystyrene foams

Journal of the Mechanical Behavior of Materials
This work studies the notch effect and the influence of particle size on the fracture behavior of Expanded Polystyrene (EPS) foams with U-shaped notches.
Martin Pablo, Cabrera Iñigo, Miranda Marina, Cicero Sergio, Castro Jorge   +4 more
doaj   +1 more source

Encoded Cell‐Material Interactions to Reroute Cytokine Signaling for Regenerative Medicine

Advanced Healthcare Materials, EarlyView.
We present native MATRIX (Material Activated To Regulate Inducible gene eXpression), a co‐engineered material‐cell platform. Surfaces functionalized with antibodies for endogenous soluble ligands (e.g., IL‐1β or IL‐6) capture and immobilize ligands for presentation to a cognate, engineered synthetic Notch receptor, releasing a transcription factor (TF)
Zachary M. Eidman, Jhanvi Sharma, Joanne C. Lee, Nicholas F. Schulze, Hannah J. Brien, Kevin C. Corn, Marjan Rafat, Jonathan M. Brunger   +7 more
wiley   +1 more source

Structural, biochemical and biophysical characterisation of human transcription factor RBP-Jκ [PDF]

, 2006
RBP-Jκ serves as interaction partner for both cellular and viral proteins. The protein mediates cellular and Epstein-Barr viral signal transduction, which in both cases results in dedifferentiation or immortalization of the cell.
Henning, Karen
core  

The structural and functional significance of lipid-binding properties of human Notch ligands [PDF]

The Notch receptor and its canonical ligands Jagged/Serrate and Delta-like form part of a core metazoan juxtacrine signal transduction pathway crucial for development and tissue homeostasis.
Feng, Xinyi
core   +1 more source