Results 41 to 50 of about 2,848,207 (306)

A Study on the Morphology of the Suprascapular Notch and Its Distance from the Glenoid Cavity [PDF]

Journal of Clinical and Diagnostic Research, 2013
Introduction: A suprascapular nerve entrapment can occur at the suprascapular notch or at the spinoglenoid notch. So, the size and shape of the suprascapular notch are associated with suprascapular entrapment neuropathy as well as with an injury to ...
Muralidhar Reddy Sangam, Sattiraju Sri Sarada Devi, Karumanchi Krupadanam, Kolla Anasuya   +3 more
doaj   +1 more source

Evaluation of anterior cruciate ligament injury and intercondylar notch stenosis in patients with knee osteoarthritis with MRI

Van Tıp Dergisi, 2020
INTRODUCTION: We aimed to evaluate intercondylar notch morphology of femur in patients with knee osteoarthritis (OA) and to investigate the relation of anterior cruciate ligament (ACL) injury.
Ayşe Serap Akgün
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Translaminar fracture limit curves for U-notched glass/epoxy composite laminates with different layup configurations subjected to mixed mode- I/II loading

Composites Part C: Open Access
Characterization of FRP composite laminate subjected to mixed-mode loading is one of the challenging topics in fracture mechanics. In this study, numerous experiments are conducted on U-notched rectangular tension (UNRT) specimens of various tip radii ...
E. Pirhadi, A.R. Torabi, Sahel Shahbaz, M. Petrů, S.S. R․ Koloor   +4 more
doaj   +1 more source

Coupling Finite Element Analysis and the Theory of Critical Distances to Estimate Critical Loads in Al6060-T66 Tubular Beams Containing Notches

Metals, 2020
This paper validates a methodology for the estimation of critical loads in tubular beams containing notch-type defects. The methodology is particularized for the case of Al6060-T66 tubular cantilever beams containing U-shaped notches.
Marcos Sánchez, Sergio Cicero, Borja Arroyo, José Alberto Álvarez   +3 more
doaj   +1 more source

Brittle fracture of U-notched graphite plates under mixed mode loading

Materials & Design, 2012
Abstract Brittle fracture of isostatic polycrystalline graphite is studied experimentally, theoretically and numerically using U-notched samples under mode I and mixed mode loading (I + II) considering different combinations of the notch radius and the tilt angle of the notch.
Berto F., Lazzarin P., Marangon C.
openaire   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Numerical predictions of U-notched sample failure based on a discrete energy argument [PDF]

Theoretical and Applied Fracture Mechanics, 2019
Abstract Kodsi (2016) proposed a criterion for isotropic, linear elastic media in a brittle state applicable to both sharp and blunt notches. Fracture toughness and material strength are the only parameters required to operate the criterion. This paper provides a formulation of the criterion specific to blunt notches and further examines the ...
Zahedi, S.A., Kodsi, C., Berto, F.
openaire   +2 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Fracture assessment of U-notched graphite specimens by means of cohesive zone model

Procedia Structural Integrity, 2020
Abstract Various types of graphite have gained interest in many industrial applications due to their high strength and excellent heat tolerance. However, due to the brittle nature of this material, presence of stress concentrators such as notches and geometrical discontinuities considerably re-duces the overall loading bearing of the graphite ...
N. Razavi, H.R. Majidi, F. Berto, M.R. Ayatollahi   +3 more
openaire   +1 more source