Results 51 to 60 of about 4,533,013 (299)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Identification of epidermal Pdx1 expression discloses different roles of Notch1 and Notch2 in murine KrasG12D-induced skin carcinogenesis in vivo [PDF]

, 2010
Background The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis.
Mazur Pawel K., Radtke, Freddy, Freddy Radtke, Roland M Schmid, Schmid, Roland M., Nakhai Hassan, Grüner, Barbara M., Pawel K Mazur, Schmid Roland M., Barbara M. Grüner, Bence Sipos, Nakhai, Hassan, Jens T Siveke, Strobl Lothar J., Siveke, J.T., Mazur, P.K., Radtke Freddy, Sipos, Bence, Radtke, F., Barbara M Grüner, Zimber-Strobl Ursula, Nakhai, H., Jens T. Siveke, Sipos, B., Grüner, B.M., Schmid, R.M., Strobl, Lothar J., Grüner Barbara M., Strobl, L.J., Lothar J Strobl, Lothar J. Strobl, Zimber-Strobl, Ursula, Hassan Nakhai, Pawel K. Mazur, Roland M. Schmid, Mazur, Pawel K., Ursula Zimber-Strobl, Sipos Bence, Siveke Jens T., Zimber-Strobl, U., Siveke, Jens T.   +40 more
core   +3 more sources

Leptin and Notch Signaling Cooperate in Sustaining Glioblastoma Multiforme Progression

Biomolecules, 2020
Glioblastoma multiforme (GBM) is the most malignant form of glioma, which represents one of the commonly occurring tumors of the central nervous system.
Salvatore Panza, Umberto Russo, Francesca Giordano, Antonella Leggio, Ines Barone, Daniela Bonofiglio, Luca Gelsomino, Rocco Malivindi, Francesca Luisa Conforti, Giuseppina Daniela Naimo, Cinzia Giordano, Stefania Catalano, Sebastiano Andò   +12 more
doaj   +1 more source

Fracture assessment of U-notched graphite specimens by means of cohesive zone model

Procedia Structural Integrity, 2020
Abstract Various types of graphite have gained interest in many industrial applications due to their high strength and excellent heat tolerance. However, due to the brittle nature of this material, presence of stress concentrators such as notches and geometrical discontinuities considerably re-duces the overall loading bearing of the graphite ...
N. Razavi, H.R. Majidi, F. Berto, M.R. Ayatollahi   +3 more
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Transcriptional program of osteoblast differentiation : coordinated activation of Notch, Wnt, and TGF-[beta] signaling pathways in MC3T3 cell line [PDF]

, 2005
In order to examine the early events in osteoblast differentiation, three different model systems for osteoblast differentiation were compared: mouse pre-osteoblastic cell line MC3T3; mouse myoblastic cell line C2C12 and primary mouse calvarial ...
Zamurovic, Natasa
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity

, 2017
Abnormal enlargement of the alveolar spaces is a hallmark of conditions such as chronic obstructive pulmonary disease and bronchopulmonary dysplasia.
林泰元;曹伯年;魏淑?, Tsao, Po-Nien;Matsuoka, Chisa;Wei, Shu-Chen;Sato, Atsuyasu;Sato, Susumu;Hasegawa, Koichi;Chen, Hung-kuan;Ling, Thai-Yen;Mori, Munemasa;Cardoso, Wellington V.;Morimoto, Mitsuru   +1 more
core   +1 more source

Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach [PDF]

, 2011
Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain ...

core   +2 more sources