Results 71 to 80 of about 44,552 (307)

Effects of Edentulism on Mandibular Morphology: Evaluation of Panoramic Radiographs

open access: yesThe Scientific World Journal, 2014
Purpose. The objective of this study was to evaluate morphological changes of the mandible in edentulous and dentate subjects using panoramic radiographs. Materials and Methods. Panoramic radiographs were divided into the following three groups: Group I (
Rıdvan Okşayan   +5 more
doaj   +1 more source

PTC124 Rescues Nonsense Mutation of Two Tumor Suppressor Genes NOTCH1 and FAT1 to Repress HNSCC Cell Proliferation

open access: yesBiomedicines, 2022
(1) Background: PTC124 (Ataluren) is an investigational drug for the treatment of nonsense mutation-mediated genetic diseases. With the exception of the TP53 tumor suppressor gene, there has been little research on cancers with nonsense mutation.
Ming-Han Wu   +9 more
doaj   +1 more source

The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis [PDF]

open access: yes, 2015
Hepatic stellate cells (HSCs) known as “master producers” and macrophages as “master regulators”, are the key cell types that strongly contribute to the progression of liver fibrosis.
Baarlen, Joop van   +3 more
core   +4 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Applicability of Semi-Quantitative Evaluation of the Intercondylar Notch

open access: yesApplied Sciences, 2021
The intercondylar notch (IN) can differ in morphology and size, influencing the contained ligaments. For a better understanding of the influence of the IN’s anatomy on knee pathologies, a classification of different shapes was proposed.
Lena Hirtler   +3 more
doaj   +1 more source

Tensile fracture analysis of a ductile polymeric material weakened by U-notches

open access: yesPolymer Testing, 2017
Abstract Fracture of a ductile epoxy polymer containing U-notches was investigated both experimentally and theoretically under pure opening mode. Two various U-notched polymeric specimens with different notch tip radii were utilized in the experiments; one of them was loaded under remote tension and the other under three-point bending.
A.R. Torabi   +2 more
openaire   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

An extension of the Equivalent Material Concept applied to fracture of U-notched solids

open access: yesProcedia Structural Integrity, 2020
The authors wish to express their gratitude to the European Union’s H2020 research and innovation program for their financial support under the LightCoce project (No 814632).
Gómez, F.J.   +2 more
openaire   +3 more sources

Systematic review on morphometric study of suprascapular notch

open access: yesAdvances in Human Biology
Suprascapular notch roofed by STSL is located in the lateral part of the superior border of scapula and medial to the base of the coracoids process. The suprascapular nerve (SN) is entrapped due to anatomical variation of the notch.
Sushma Daripelli   +2 more
doaj   +1 more source

Dynamic vibration analysis of ti-alloy gas turbine blade rotating at high speed after grind-out repair of foreign object damage [PDF]

open access: yes, 2017
Vibration analysis of gas turbine blade contributes to progress in Aerospace and Aeronautics industries. Most commonly, identification and suppression of unwanted vibration is essential need.
Madhu, E.   +3 more
core  

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