Results 71 to 80 of about 4,533,013 (299)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

The role of NOTCH2 gene in human malignant glial brain tumours [PDF]

, 2008
Background: Glioblastoma multiforme (GBM), astrocytoma (A) and oligodendroglioma (OG) are the neoplasms of the glial lineage in the Central Nervous System (CNS).
Sivasankaran, Balasubramanian
core   +1 more source

Tensile fracture analysis of a ductile polymeric material weakened by U-notches

Polymer Testing, 2017
Abstract Fracture of a ductile epoxy polymer containing U-notches was investigated both experimentally and theoretically under pure opening mode. Two various U-notched polymeric specimens with different notch tip radii were utilized in the experiments; one of them was loaded under remote tension and the other under three-point bending.
A.R. Torabi, A.S. Rahimi, M.R. Ayatollahi   +2 more
openaire   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Modelling delta-notch perturbations during zebrafish somitogenesis [PDF]

, 2013
The discovery over the last 15 years of molecular clocks and gradients in the pre-somitic mesoderm of numerous vertebrate species has added significant weight to Cooke and Zeeman's ‘clock and wavefront’ model of somitogenesis, in which a travelling ...
Baker, R. E., Maini, P. K., Murray, PJ, Baker, RE, Baker, Ruth E., Murray, Philip J., Maini, PK, Murray, P J, Maini, Philip K.   +8 more
core   +1 more source

Effects of Edentulism on Mandibular Morphology: Evaluation of Panoramic Radiographs

The Scientific World Journal, 2014
Purpose. The objective of this study was to evaluate morphological changes of the mandible in edentulous and dentate subjects using panoramic radiographs. Materials and Methods. Panoramic radiographs were divided into the following three groups: Group I (
Rıdvan Okşayan, Bayram Asarkaya, Nizamettin Palta, İrfan Şimşek, Oral Sökücü, Eren İşman   +5 more
doaj   +1 more source

Experimental verification of the virtual isotropic material concept for the last-ply-failure of U-notched quasi-isotropic E-glass/epoxy composite laminates under tension-shear loading

Journal of Industrial Textiles, 2022
Fracture investigation of U-notched E-glass/epoxy laminated composite specimens with various notch root radii is performed under mixed mode I/II loading conditions both experimentally and theoretically.
Ali Reza Torabi, Ebrahim Pirhadi
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Delta-like 4 is indispensable in thymic environment specific for T cell development. [PDF]

, 2008
The thymic microenvironment is required for T cell development in vivo. However, in vitro studies have shown that when hematopoietic progenitors acquire Notch signaling via Delta-like (Dll)1 or Dll4, they differentiate into the T cell lineage in the ...
Holländer, Georg, Habu, S., Holländer, G. A., Hozumi, K., Hirano, K, Mailhos, C, Ken-ichi Hirano, Negishi, N, Saulius Zuklys, Habu, S, Zuklys, S, Yahata, T., Sonoko Habu, Mailhos, C., Georg A. Holländer, Naoko Negishi, Ando, K., Ando, K, Kiyoshi Ando, Holländer, GA, Shima, D. T., Negishi, N., Carolina Mailhos, Hozumi, K, Yahata, T, Shima, DT, Hirano, K., Katsuto Hozumi, Takashi Yahata, David T. Shima, Zuklys, S.   +30 more
core   +1 more source