Results 71 to 80 of about 3,263,406 (307)

Astrocyte heterogeneity in brain metastases

Molecular Oncology, EarlyView.
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver, Neibla Priego, Manuel Valiente   +2 more
wiley   +1 more source

Notch Signaling In Solid Tumors [PDF]

In recent years a substantial body of evidence derived from not only preclinical but also clinical studies has accumulated in support of Notch signaling playing important oncogenic roles in several types of cancer.
Koch, Ute, Radtke, Freddy
core   +1 more source

Miniature transparent UWB antenna with tunable notch for green wireless applications [PDF]

, 2011
Copyright @ 2011 IEEEA miniature transparent UWB antenna with tunable notch that can be incorporated with a solar panel for harnessing solar energy has been proposed and presented.
AbuTarboush, HF, Yuk, TI, T. I. Yuk, Nilavalan, R, Y. Y. Sun, T. Peter, S. W. Cheung, H. F. AbuTarboush, Cheung, SW, R. Nilavalan, Peter, T, Sun, YY   +11 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Fungal CSL transcription factors [PDF]

, 2007
Background: The CSL (CBF1/RBP-J kappa/Suppressor of Hairless/LAG-1) transcription factor family members are well-known components of the transmembrane receptor Notch signaling pathway, which plays a critical role in metazoan development. They function as
Prevorovsky, M, Folk Petr, Folk, P, Puta, F, Půta František, Převorovský Martin   +5 more
core   +1 more source

Notch-signaling regulates the transition of atoh1a cycling progenitors towards atoh1b committed cells. [PDF]

, 2020
A-B) Whole mount double in situ hybridization with atoh1a (green) and atoh1b (magenta) in Tg[tp1:GFP] embryos (readout of Notch-activity in white). A’-B’) Reconstructed transverse views of embryos displayed as dorsal views in (A-B) through the point ...
Carla Belmonte-Mateos (8394240), Cristina Pujades (346486), Ivan Belzunce (8394237)   +2 more
core   +1 more source

Failure configuration and evaluation of hybrid CFRP-GFRP laminates using innovative Arcan fixture: Experimental and simulation approach

Composites Part C: Open Access
This study successfully explored and evaluated the impact of notches modification in U, V, and square shapes on both tensile and shear strength using Arcan fixture.
Ariyana Dwiputra Nugraha, Daffa Alandro, Kevin Gausultan Hadith Mangunkusumo, Muhammad Kusni, Yi Chieh Wu, Muhammad Akhsin Muflikhun   +5 more
doaj   +1 more source

Coupling Finite Element Analysis and the Theory of Critical Distances to Estimate Critical Loads in Al6060-T66 Tubular Beams Containing Notches

Metals, 2020
This paper validates a methodology for the estimation of critical loads in tubular beams containing notch-type defects. The methodology is particularized for the case of Al6060-T66 tubular cantilever beams containing U-shaped notches.
Marcos Sánchez, Sergio Cicero, Borja Arroyo, José Alberto Álvarez   +3 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The interaction of Notch signalling, haemodynamic flow and angiogenesis in Von Hippel-Lindau mutant zebrafish. [PDF]

, 2013
Introduction: There is increasing evidence that the endothelium is able to transduce circulatory force into signals which influence angiogenic behaviour.
Watson, Oliver
core