Results 131 to 140 of about 481,772 (339)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Characterization of Strategic Deconflicting Service Impact on Very Low-Level Airspace Capacity

open access: yesDrones
European airspace is poised for significant transformation as it prepares to accommodate a new class of unmanned traffic that will reshape the transport of people and goods.
Zhiqiang Liu   +2 more
doaj   +1 more source

Measuring U-space social and environmental impact

open access: yes
U-space will enable urban air mobility (UAM) on a wide scale, facilitating a variety of use cases (e.g., medical and emergency transport, delivery of goods, passenger transport services). Social acceptance and impact on citizens is not completely understood in this growing scenario.
Baena, Miguel   +7 more
openaire   +3 more sources

U-Space Contingency Management Based on Enhanced Mission Description

open access: yesAerospace
Loss of communication, low battery, or bad weather conditions (like high-speed wind) are currently managed by performing a return to launch (RTL) point maneuver. However, the execution of this procedure can pose a safety threat since it has not been considered within the mission planning process. This work proposes an advanced management of contingency
Jose L. Munoz-Gamarra   +2 more
openaire   +4 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Moduli spaces of instantons in flag manifold sigma models. Vortices in quiver gauge theories

open access: yesJournal of High Energy Physics
In this paper, we discuss lumps (sigma model instantons) in flag manifold sigma models. In particular, we focus on the moduli space of BPS lumps in general Kähler flag manifold sigma models. Such a Kähler flag manifold, which takes the form U n 1 + ⋯ + n
Toshiaki Fujimori   +2 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Regularity of weak solutions of the Navier-Stokes equations near the smooth boundary

open access: yesElectronic Journal of Differential Equations, 2005
Any weak solution u of the Navier-Stokes equations in a bounded domain satisfying the Prodi-Serrin's conditions locally near the smooth boundary cannot have singular points there.
Zdenek Skalak
doaj  

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