Results 31 to 40 of about 8,623,503 (244)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Low Altitude Airspace: how enterprises discover a new business dimension
GEOmedia, 2019 The development of Low Altitude Airspace activities is a great opportunity for many companies. Work carried out by drones (inspections, surveillance and control, mapping etc.) will be supported by other new activities and services that will pave the way ...
Chiara Mozzetti, Alberto Devitis
doaj
On a higher-order evolution equation with a Stepanov-bounded solution
International Journal of Mathematics and Mathematical Sciences, 2004 We study strong solutions u:ℝ→X, a Banach space X, of the nth-order evolution equation u(n)−Au(n−1)=f, an infinitesimal generator of a strongly continuous group A:D(A)⊆X→X, and a given forcing term f:ℝ→X.
Aribindi Satyanarayan Rao
doaj +1 more source
Remark on the Cauchy problem for the evolution p-Laplacian equation
Journal of Inequalities and Applications, 2017 In this paper, we prove that the semigroup S ( t ) $S(t)$ generated by the Cauchy problem of the evolution p-Laplacian equation ∂ u ∂ t − div ( | ∇ u | p − 2 ∇ u ) = 0 $\frac{\partial u}{\partial t}-\operatorname{div}(|\nabla u|^{p-2}\nabla u)=0$ ( p > 2
Liangwei Wang, Jngxue Yin, Jinde Cao
doaj +1 more source
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
The Astrophysical Journal LettersWe report the results of first ever spectropolarimetric analyses of the Galactic ultraluminous X-ray pulsar Swift J0243.6+6124 during the 2023 outburst using quasi-simultaneous IXPE, NICER, and NuSTAR observations.
Seshadri Majumder +4 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source