Results 161 to 170 of about 8,536 (192)

QKI ensures splicing fidelity during cardiogenesis by engaging the U6 tri-snRNP to activate splicing at weak 5ʹ splice sites

Akinyi MV, Yao W, Zeman J, Hipp C, Bartsch D, Heaven L, Le Roux CA, Starner AC, Yuan F, Bartels MD, Zhao F, Ha HL, Sharma R, Choudhary B, Biayna J, Brandes RP, Dumbović G, Ray A, Wittig I, Muench C, Sattler M, Van Nostrand EL, Kurian L.   +22 more
europepmc   +1 more source

Competing 5’ splice sites of SRC1/HEH1 are marked for alternative splicing by U5 and U6 snRNAs during the B to Bact transition of the spliceosome

Banyal AK, Choudhuri P, Pillai BR, Varikkapulakkal A, Mishra SK.   +4 more
europepmc   +1 more source

Analysis of yeast PRP8 protein and its role in U5 SNRNP assembly

, 2005
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Protein-RNA interactions in 20S U5 snRNPs

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1991
The interaction of the U5-specific polypeptides with U5 snRNA was investigated by comparison of the differential accessibility towards nucleases and dimethylsulfate of defined regions of U5 snRNA in purified 20S and 10S U5 snRNPs. While 20S U5 snRNPs contain eight U5-specific proteins in addition to the common proteins, the 10S U5 snRNPs contain only ...
M, Bach, R, Lührmann
openaire   +2 more sources

Roles of the U5 snRNP in spliceosome dynamics and catalysis

Biochemical Society Transactions, 2004
Most protein-coding genes in eukaryotes are interrupted by non-coding intervening sequences (introns), which must be precisely removed from primary gene transcripts (pre-mRNAs) before translation of the message into protein. Intron removal by pre-mRNA splicing occurs in the nucleus and is catalysed by complex ribonucleoprotein machines called ...
I A, Turner, C M, Norman, M J, Churcher, A J, Newman   +3 more
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Isolation of U5 snRNP particles.

Cytobios, 1989
A method for the isolation of intact U5 small nuclear RNP particles from HeLa cells has been developed. The procedure includes nuclear extraction of the particles at moderate ionic strength, fractionation in agarose gels, electrophoretic transfer on DEAE cellulose paper and elution with ammonium chloride.
Pironcheva, G., Zhelev, N., Russev, G.
openaire   +1 more source

A U1/U4/U5 snRNP Complex Induced by a 2′- O -Methyl-Oligoribonucleotide Complementary to U5 snRNA

Science, 1996
Nuclear messenger RNA splicing involves multiple interactions between the five spliceosomal small nuclear ribonucleoprotein particles (snRNPs) U1, U2, U4, U5, and U6 and numerous spliceosomal proteins. Here it is shown that binding of a 2′- O -methyl-oligoribonucleotide complementary to U5 small nuclear RNA (snRNA ...
G, Ast, A M, Weiner
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U5 snRNP particles bind pre-messenger RNA in vitro.

Cytobios, 1989
The ability of purified U5 small nuclear RNP particles (U5 snRNPs) to bind in vitro pre-mRNA of the human beta-globin gene was investigated. The transcript which contained sequences, corresponding to the second intron and fragments of the second and third exons of the gene was bound to U5 snRNP particles in the presence of antibodies specific against ...
G L, Pironcheva, G, Russev
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Phylogenic Analysis of Cellular Life Forms Using U5 Snrnp Components

Journal of Applied Bioinformatics & Computational Biology, 2013
Phylogenic Analysis of Cellular Life Forms Using U5 Snrnp Components The conserved sequences of certain molecules in existing cellular life forms, like those reside in RNA splicing, are suitable for phylogenetic analysis. In view of the growing interests in the field of primate’s evolution, protein components of the U5 snRNP were analyzed using NCBI ...
openaire   +1 more source

SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome.

RNA (New York, N.Y.), 1995
Pre-spliceosomes, formed in HeLa nuclear extracts and isolated by sedimentation on glycerol gradients, were chased into spliceosomes, the macromolecular enzyme that catalyzes intron removal. We demonstrate that the pre-spliceosome to spliceosome transition was dependent on ATP hydrolysis and required both a U-rich small nuclear ribonucleoprotein (U ...
R F, Roscigno, M A, Garcia-Blanco
openaire   +1 more source