Early SOX9 Activation Primes Hippo–YAP/TAZ Rewiring During Glioblastoma Stemness Acquisition [PDF]
Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.ABSTRACT Glioblastoma progression is driven by stemness acquisition and cellular plasticity, yet the temporal and spatial organization of these processes remains incompletely defined. In this study, single‐cell RNA sequencing, pseudotime reconstruction, spatial transcriptomics, and in vitro and in vivo functional assays were integrated to delineate the
Maimaitili Mijiti +15 more
wiley +2 more sources
Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy [PDF]
, 2011 Background: Even in the presence of oxygen, malignant cells often highly depend on glycolysis for energy generation, a phenomenon known as the Warburg effect.
Stefan Walenta +26 more
core +2 more sources
Contribution of 3q26-29 gene cluster to glioma invasion [PDF]
, 2015 Diffuse gliomas are the most common and lethal brain tumors. Cell invasion into the surrounding brain tissue is a hallmark feature of glioma. Understanding the mechanism of glioma invasion could lead to the discovery of novel therapeutic strategies to ...
Ramadoss, Archana
core +1 more source
Hypoxia helps glioma to fight therapy [PDF]
, 2009 Despite major improvements in the surgical management the prognosis for patients bearing malignant gliomas is still dismal. Malignant gliomas are notoriously resistant to treatment and the survival time of patients is between 3-8 years for low-grade and
Amberger-Murphy, Verena +1 more
core +2 more sources
, 2022 Dielectrophoresis have been widely used as rapid and label-free cell characterization and separation method in biology. Integration of an electrode array in a microchannel enabled high throughput yet low-cost alternative to conventional cell separation ...
Sharbati, Pouya, Elitaş, Meltem
core +1 more source
Overexpression of miR‑145 in U87 cells reduces glioma cell malignant phenotype and promotes survival after in vivo implantation [PDF]
, 2015 In the present study, we sought to elucidate the effect of miR‑145 on glioma cell progression and its mechanisms of action. We examined the effects of miR‑145 on proliferation and invasion of U87 glioma cells and on capillary tube formation.
Nguyen, Monique +7 more
core +2 more sources
Receptors for hyaluronic acid and poliovirus: a combinatorial role in glioma invasion? [PDF]
, 2012 BACKGROUND: CD44 has long been associated with glioma invasion while, more recently, CD155 has been implicated in playing a similar role. Notably, these two receptors have been shown closely positioned on monocytes.
James R Smith +11 more
core +2 more sources
PUMA mediated afatinib-induced apoptosis in glioma cells
, 2021 Introduction Afatinib exhibits a tumor-inhibiting effect in different cancers by inducing apoptosis; however, its pro-apoptosis role in glioma cells is still not fully understood. Material and methods In the current study, two glioma cell lines (U373-MG
Xinyue Sun +3 more
core +1 more source
The molecular role of non-canonical Notch signaling via Deltex-1 in high grade glioma [PDF]
, 2011 Glioblastoma Multiforme is a WHO grade IV brain tumor with glial characteristics leading to more years of life lost than any other cancer. A better understanding of GBM biology and valid animal models are the two key elements to improved therapeutic ...
Huber, Roland Martin
core +1 more source
DCEF-stimulated activation of Erk1/2, JNK, and p38 in U87 glioma cells.
, 2013 U87 glioma cells were stimulated with 200 mV/mm DCEF for 0, 15, 30, 45, or 60 minutes (A). The cell lysate was probed with antibodies specific for p-Akt, total Akt, p-Erk1/2, total Erk1/2, p-JNK, total JNK, p-p38, and total p38. Activation of Erk1/2, JNK,
Tunan Chen (402765) +5 more
core +1 more source