Results 21 to 30 of about 23,643 (220)

Indirubin exerts anticancer effects on human glioma cells by inducing apoptosis and autophagy

AMB Express, 2020
Glioma causes significant mortality across the world and the most aggressive type of brain cancer. The incidence of glioma is believed to increase in the next few decades and hence more efficient treatment strategies need to be developed for management ...
Zhaohui Li, Han Wang, Jun Wei, Liang Han, Zhigang Guo   +4 more
doaj   +1 more source

Axitinib induces senescence-associated cell death and necrosis in glioma cell lines: The proteasome inhibitor, bortezomib, potentiates axitinib-induced cytotoxicity in a p21(Waf/Cip1) dependent manner. [PDF]

, 2017
Glioblastoma is associated with a poor overall survival despite new treatment advances. Antiangiogenic strategies targeting VEGF based on tyrosine kinase inhibitors (TKIs) are currently undergoing extensive research for the treatment of glioma.
Amantini, C, BERNARDINI, Giovanni, CARDINALI, CLAUDIO, MORELLI, MARIA BEATRICE, Nabissi, M, SANTONI, Angela, Santoni, G., Santoni, M   +7 more
core   +1 more source

Retinol dehydrogenase 10 promotes metastasis of glioma cells via the transforming growth factor-β/SMAD signaling pathway

Chinese Medical Journal, 2019
. Background:. Glioma is the most common primary malignant tumor in the central nervous system. Because of the resistance of glioma to chemoradiotherapy and its aggressive growth, the survival rate of patients with glioma has not improved.
Feng Guan, Zhuang Kang, Liang Wang, Ke Wang, Bei-Bei Mao, Wei-Cheng Peng, Bo-Lun Zhang, Zhen-Yang Lin, Jun-Ting Zhang, Zhi-Qiang Hu, Peng Lyu   +10 more
doaj   +1 more source

Radiosensitization of gliomas by intracellular generation of 5-fluorouracil potentiates prodrug activator gene therapy with a retroviral replicating vector. [PDF]

, 2014
A tumor-selective non-lytic retroviral replicating vector (RRV), Toca 511, and an extended-release formulation of 5-fluorocytosine (5-FC), Toca FC, are currently being evaluated in clinical trials in patients with recurrent high-grade glioma (NCT01156584,
Gruber, Harry E, Hiraoka, Kei, Inagaki, Akihito, Iwamoto, Keisuke S, Jolly, Douglas J, Kamijima, Shuichi, Kasahara, Noriyuki, McBride, William H, Micewicz, Ewa, Robbins, Joan M, Takahashi, Masamichi, Valdes, Gilmer   +11 more
core   +2 more sources

Knockdown of DCLK1 Inhibits Proliferation, Migration and Invasion of Glioma Cells

Zhongliu Fangzhi Yanjiu, 2020
Objective To investigate the effects of DCLK1 on the proliferation, migration and invasion of glioma cells and their mechanisms. Methods The mRNA and protein expression of DCLK1 in glioma tissues and glioma cell lines U87 and A172 were detected by RT ...
YU Jie, YANG Feng, DENG Jian, HU Linwang
doaj   +1 more source

Lectin from Dioclea violacea induces autophagy in U87 glioma cells

International Journal of Biological Macromolecules, 2019
The antitumor activity of DVL, a lectin purified from Dioclea violacea seeds, on the U87 human glioma cell line was evaluated and compared with Canavalia ensiformis lectin (ConA). Treatment with DVL (10-100 μg/mL; 24-96 h) induced alterations in cell morphology, decreased cell numbers and clonogenic survival in a time- and concentration-dependent ...
Ana Paula M, Nascimento, Ingrid A V, Wolin, Priscilla G, Welter, Isabella A, Heinrich, Alfeu, Zanotto-Filho, Vinicius J S, Osterne, Claudia F, Lossio, Mayara T L, Silva, Kyria S, Nascimento, Benildo S, Cavada, Rodrigo B, Leal   +10 more
openaire   +2 more sources

Effect of RNA interference-mediated S100A9 gene silencing on proliferation and self-renewal of U87 glioma stem cells in vitro

Di-san junyi daxue xuebao, 2019
Objective To investigate the effect of S100A9 gene silencing on proliferation and self-renewal ability of human U87 glioma stem cells. Methods Human U87 glioma stem cells were infected with shRNA-S100A9 lentivirus for S100A9 gene silencing, and the ...
CHEN Chen, CHEN Song, HUO Gang
doaj   +1 more source

Overexpression of Large-Conductance Calcium-Activated Potassium Channels in Human Glioblastoma Stem-Like Cells and Their Role in Cell Migration [PDF]

, 2017
Glioblastomas (GBMs) are brain tumors characterized by diffuse invasion of cancer cells into the healthy brain parenchyma, and establishment of secondary foci. GBM cells abundantly express large-conductance, calcium-activated potassium (BK) channels that
Abdullaev, Bao, Bednarczyk, Beier, Brenner, Brescia, Buttigieg, Calogero, Catacuzzeno, Catacuzzeno, Catacuzzeno, Catacuzzeno, Chen, Choy, Cuddapah, Eckel-Passow, Edalat, Eskandari, Fioretti, Fioretti, Gu, Holland, Inoue, Kyle, Liu, Maher, Maugeri-Saccà, Maugeri-Saccà, McFerrin, Meera, Park, Ransom, Ruggieri, Sforna, Sforna, Shruti, Siemen, Sontheimer, Soria, Soroceanu, Steinle, Torres, Turner, Wang, Weaver, Weiger, Wondergem, Wu, Yu, Zhang   +49 more
core   +1 more source

Investigating the role of Hedgehog/GLI1 signaling in glioblastoma cell response to temozolomide. [PDF]

, 2018
Resistance to chemotherapy substantially hinders successful glioblastoma (GBM) treatment, contributing to an almost 100% mortality rate. Resistance to the frontline chemotherapy, temozolomide (TMZ), arises from numerous signaling pathways that are ...
Day, Emily S, Gleghorn, Jason P, Ioele, Stephen A, Melamed, Jilian R, Morgan, Joshua T, Sims-Mourtada, Jennifer   +5 more
core   +1 more source

A Novel Therapeutic Strategy for the Treatment of Glioma, Combining Chemical and Molecular Targeting of Hsp90a [PDF]

, 2011
Hsp90α's vital role in tumour survival and progression, together with its highly inducible expression profile in gliomas and its absence in normal tissue and cell lines validates it as a therapeutic target for glioma.
Adi Mehta, Altieri, Amal Shervington, Bagatell, Basso, Bisht, Boado, Brader, Braga-Basaria, Burger, Chang, Chatterjee, Chinmay Munje, Chiosis, Clarke, Cohen-Saidon, Cruickshanks, Duerfeldt, Elbashir, Eustace, Gaspar, Gazitt, Goetz, Graner, Han, Isaacs, Jane, Kamal, Kamal, Karkoulis, Koren, Kumar, Lang, Lanneau, Leroy Shervington, Li, Luo, McAnuff, McCollum, Padmini, Porter, Pu, Pu, Sauvageot, Schiffelers, Shervington, Shim, Siegelin, Solit, Sreedhar, Stommel, Walsh, Whitesell, Yang, Yen, Yu   +55 more
core   +2 more sources