Results 11 to 20 of about 23,643 (220)

EXPRESSION OF UBIQUITIN SPECIFIC PEPTIDASE GENES IN IRE1 KNOCKDOWN U87 GLIOMA CELLS UPON GLUCOSE DEPRIVATION [PDF]

Biotechnologia Acta, 2016
We have studied the effect of glucose deprivation on the expression of genes encoding for ubiquitin specific peptidases — USP and autophagy related 7 ATG7 in U87 glioma cells in relation to inhibition of inositol requiring enzyme-1 (IRE1).
O. H. Minchenko, O. O. Riabovol, O. V. Halkin, S. V. Danilovskyi, D. O. Minchenko, O. O. Ratushna   +5 more
doaj   +4 more sources

Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]

, 2016
Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James, Arias, Angelo, Cates, Charles, Cayanan, Geraldine, Fung, Jennifer, Greene, Lloyd, Karpel-Massler, Georg, Lamé, Michael, Nakayama Wong, Lynn, Rowland, Douglas, Sidorov, Maxim, Siegelin, Markus   +11 more
core   +14 more sources

lncRNAs combine and crosstalk with NSPc1 in ATRA-induced differentiation of U87 glioma cells. [PDF]

Oncol Lett, 2019
Nervous system polycomb 1 (NSPc1) is a member of the polycomb group (PcG) family of proteins and has been demonstrated to maintain the differentiation and pluripotency of stem cells. Long non-coding RNAs (lncRNAs) have been demonstrated to be involved in the control of pluripotency and differentiation in embryonic and pluripotent cells.
Liang Z, Wang Y, Li H, Sun Y, Gong Y.
europepmc   +4 more sources

Could Upregulated Hsp70 Protein Compensate for the Hsp90-Silence-Induced Cell Death in Glioma Cells? [PDF]

, 2014
The molecular chaperone heat shock protein 90 alpha (Hsp90α) has been recognized in various tumours including glioma. This pilot study using a proteomic approach analyses the downstream effects of Hsp90 inhibition using 17-allylamino-17 ...
Khan, Zarine Jamsher, Munje, Chinmay, Shervington, Amal A, Shervington, Leroy Alexander   +3 more
core   +4 more sources

Resveratrol represses YKL-40 expression in human glioma U87 cells [PDF]

BMC Cancer, 2010
Abstract Background Glioblastoma multiforme (GBM) is the most malignant intracranial tumour that develops in both adults and children. Microarray gene analyses have confirmed that the human YKL-40 gene is one of the most over-expressed genes in these tumours but not in normal brain tissue.
Kawai Nobuyuki, Miyake Keisuke, Okada Masaki, Diah Suwarni, Matsumoto Kensuke, Zhang Xiang, Murao Koji, Zhang Wei, Fei Zhou, Tamiya Takashi   +9 more
openaire   +3 more sources

Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells

BMC Cancer, 2018
Background Temozolomide (TMZ)-induced side effects and drug tolerance to human gliomas are still challenging issues now. Our previous studies showed that honokiol, a major bioactive constituent of Magnolia officinalis (Houpo), is safe for normal brain ...
Chung-Ching Chio, Kung-Yen Chen, Cheng-Kuei Chang, Jian-Ying Chuang, Chih-Chung Liu, Shing-Hwa Liu, Ruei-Ming Chen   +6 more
doaj   +1 more source

MicroRNA-34a Suppresses Cell Proliferation and Induces Apoptosis in U87 Glioma Stem Cells [PDF]

Technology in Cancer Research & Treatment, 2012
Tumor stem cells (TSCs) have been identified in many malignant tumors and are unique in their self-renewal, multi-differentiation and tumor growth maintenance capabilities. MicroRNAs (miRNAs) are small endogenous, non-coding RNAs that predominately modulate target gene expression at the post-transcriptional level.
Lihua, Sun, Zhifeng, Wu, Yun, Shao, Yi, Pu, Weifeng, Miu, Jianshe, Yao, Yiping, Wu, Zhengxiang, Yang   +7 more
openaire   +2 more sources

Shikonin kills glioma cells through necroptosis mediated by RIP-1.

PLoS ONE, 2013
Background and purposeShikonin was reported to induce necroptosis in leukemia cells, but apoptosis in glioma cell lines. Thus, it is needed to clarify whether shikonin could cause necroptosis in glioma cells and investigate its underlying mechanisms ...
Chuanjiang Huang, Yinan Luo, Jingwei Zhao, Fuwei Yang, Hongwei Zhao, Wenhai Fan, Pengfei Ge   +6 more
doaj   +1 more source

LncRNA‐H19 gene plays a significant role in regulating glioma cell function

Molecular Genetics & Genomic Medicine, 2021
Background Glioma is an aggressive adult primary cancer, and is characterized by low cure rate, poor prognosis, and high recurrence. The present study aimed to investigate the effect of lncRNA‐H19 gene silencing on glioma cell function.
Ping Liu, Xinqiong Huang, Haijun Wu, Guoling Yin, Liangfang Shen   +4 more
doaj   +1 more source

Activation of protease-activated receptor 2 reduces glioblastoma cell apoptosis [PDF]

, 2014
BACKGROUND: The pathogenesis of glioma is unclear. The disturbance of the apoptosis process plays a critical role in glioma growth. Factors regulating the apoptosis process are to be further understood. This study aims to investigate the role of protease
Chunlei Tian, Lei Wang, Ran Luo, Xiongwei Wang, Yuanxun Dong   +4 more
core   +1 more source