Results 21 to 30 of about 3,812 (167)
Characterization of ubiquitin-activating enzyme Uba1 in the nucleus by its mammalian temperature-sensitive mutant. [PDF]
PLoS ONE, 2014 Temperature-sensitive (ts) CHO-K1 mutant tsTM3 exhibits chromosomal instability and cell-cycle arrest in the S to G2 phases with decreased DNA synthesis at the nonpermissive temperature, 39°C.
Kimihiko Sugaya +4 more
doaj +1 more source
EMJ Hematology, 2023 BACKGROUND AND AIMS In 2020, three somatic mutations in the X-linked gene UBA1, coding for an essential ubiquitin activating enzyme, were reported to cause VEXAS syndrome, a novel haemato-inflammatory disease that manifests with both cytopenias and autoinflammation.1 The mutations alter the start codon (M41) of the cytoplasmic isoform of UBA1 ...
Sakuma, Maki +6 more
openaire +1 more source
Prognostic Impact of UBA1 Expression in Breast Cancer. [PDF]
J CancerKoch J +7 more
europepmc +2 more sources
An adaptive stress response that confers cellular resilience to decreased ubiquitination
Nature Communications, 2023 Ubiquitination is a post-translational modification initiated by the E1 enzyme UBA1, which transfers ubiquitin to ~35 E2 ubiquitin-conjugating enzymes. While UBA1 loss is cell lethal, it remains unknown how partial reduction in UBA1 activity is endured ...
Liam C. Hunt +16 more
doaj +1 more source
Uba1 functions in Atg7- and Atg3-independent autophagy [PDF]
Nature Cell Biology, 2013 Autophagy is a conserved process that delivers components of the cytoplasm to lysosomes for degradation. The E1 and E2 enzymes encoded by Atg7 and Atg3 are thought to be essential for autophagy involving the ubiquitin-like protein Atg8. Here, we describe an Atg7- and Atg3-independent autophagy pathway that facilitates programmed reduction of cell size ...
Chang, Tsun-Kai +6 more
openaire +5 more sources
Evolution of the ubiquitin-activating enzyme Uba1 (E1) [PDF]
Physica A: Statistical Mechanics and its Applications, 2017 Ubiquitin tags diseased proteins and initiates an enzyme conjugation cascade, which has three stages. The first-stage enzyme Uba1 (E1) has evolved only modestly from slime mold to humans, and is > 14 times larger than Ub. Here we use critical point thermodynamic scaling theory to connect Uba1 (E1) evolution from yeast and slime mold to fruit flies ...
Allan, Douglas C., Phillips, J. C.
openaire +2 more sources
VEXAS syndrome in myelodysplastic syndrome with autoimmune disorder
Experimental Hematology & Oncology, 2021 VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is a newly-described adult-onset inflammatory syndrome characterized by vacuoles in myeloid and erythroid precursor cells and somatic mutations affecting methionine-41 (p.Met41) in
Huijun Huang +12 more
doaj +1 more source
Acetylated Ubiquitin Modulates the Catalytic Activity of the E1 Enzyme Uba1 [PDF]
Biochemistry, 2021 Ubiquitin (Ub) signaling requires the covalent passage of Ub among E1, E2, and E3 enzymes. The choice of E2 and E3 enzymes combined with multiple rounds of the cascade leads to the formation of polyubiquitin chains linked through any one of the seven lysines on Ub. The linkage type and length act as a signal to trigger important cellular processes such
Rachel E. Lacoursiere, Gary S. Shaw
openaire +2 more sources
Journal of Immunology Research, 2020 Background. Ubiquitin-like modifier activating enzyme 1 (UBA1) is the first and major E1 activating enzyme in ubiquitin activation, the initial step of the ubiquitin-proteasome system.
Jiawei Liao +6 more
doaj +1 more source
UBA1 and DNMT3A mutations in VEXAS syndrome. A case report and literature review [PDF]
Modern Rheumatology Case Reports, 2021 ABSTRACT Vacuoles, E1 enzyme, X linked, autoinflammatory, somatic (VEXAS) syndrome is a recently described X-linked autoinflammatory condition associated with somatic mutation of the ubiquitin-like modifier activating enzyme 1 (UBA1) gene.
Farah Shaukat +3 more
openaire +2 more sources