Results 41 to 50 of about 3,812 (167)

UBA1 dysfunction in VEXAS and cancer

Oncotarget
UBA1, an X-linked gene, encodes one of the only two ubiquitin E1 enzymes, playing a pivotal role in initiating one of the most essential post-translational modifications. In late 2020, partial loss-of-function mutations in UBA1 within hematopoietic stem and progenitor cells were found to be responsible for VEXAS Syndrome, a previously unidentified ...
Sakuma, Maki, Haferlach, Torsten, Walter, Wencke   +2 more
openaire   +2 more sources

Case Report: Coexistence of Multiple Myeloma and Auricular Chondritis in VEXAS Syndrome

Frontiers in Immunology, 2022
Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome is an inflammatory disorder caused by somatic UBA1 variants, which are sometimes associated with hematological disorders, including myelodysplastic syndrome (MDS).
Haruki Matsumoto, Yuya Fujita, Masahiko Fukatsu, Takayuki Ikezoe, Kohei Yokose, Tomoyuki Asano, Naomi Tsuchida, Naomi Tsuchida, Naomi Tsuchida, Ayaka Maeda, Shuhei Yoshida, Honami Hashimoto, Jumpei Temmoku, Naoki Matsuoka, Makiko Yashiro-Furuya, Shuzo Sato, Mai Murakami, Hidenori Sato, Chiharu Sakuma, Kazumasa Kawashima, Norshalena Shakespear, Yuri Uchiyama, Yuri Uchiyama, Hiroshi Watanabe, Yohei Kirino, Naomichi Matsumoto, Kiyoshi Migita   +26 more
doaj   +1 more source

UBA1 Mutations Identify a Rare but Distinct Subtype of Myelodysplastic Syndromes

Blood, 2023
Background Mutations in UBA1 are associated with VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome, an adult-onset inflammatory disorder (Beck DB et al. NEJM 2020). Approximately 40% of VEXAS patients are also diagnosed with myelodysplastic syndromes (MDS).
Sirenko, M, Bernard, E, Creignou, M, Domenico, D, Farina, A, Ossa, JEA, Kosmider, O, Hasserjian, R, Jädersten, M, Germing, U, Sanz, G, van de Loosdrecht, AA, Gurnari, C, Follo, MY, Thol, F, Zamora, L, Pellagatti, A, Elias, HK, Haase, D, Ganster, C, Ades, L, Tobiasson, M, Palomo, L, Della Porta, MG, Huberman, K, Fenaux, P, Belickova, M, Savona, MR, Klimek, VM, Santos, FPS, Boultwood, J, Kotsianidis, I, Santini, V, Francesc Solé, Platzbecker, U, Heuser, M, Valent, P, Finelli, C, Voso, MT, Shih, LY, Ogawa, S, Fontenay, M, Jansen, JH, Cervera, J, Ebert, BL, Bejar, R, Greenberg, PL, Gattermann, N, Malcovati, L, Cazzola, M, Beck, DB, Lindberg, EH, Papaemmanuil, E   +52 more
openaire   +3 more sources

Yeast Augmented Network Analysis (YANA): a new systems approach to identify therapeutic targets for human genetic diseases [v1; ref status: indexed, http://f1000r.es/3gk]

F1000Research, 2014
Genetic interaction networks that underlie most human diseases are highly complex and poorly defined. Better-defined networks will allow identification of a greater number of therapeutic targets.
David J. Wiley, Ilona Juan, Hao Le, Xiaodong Cai, Lisa Baumbach, Christine Beattie, Gennaro D'Urso   +6 more
doaj   +1 more source

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage [PDF]

Cell Cycle, 2012
The cellular DNA damage response (DDR) machinery that maintains genomic integrity and prevents severe pathologies, including cancer, is orchestrated by signaling through protein modifications. Protein ubiquitylation regulates repair of DNA double-strand breaks (DSBs), toxic lesions caused by various metabolic as well as environmental insults such as ...
Pavel Moudry, Claudia Lukas, Libor Macurek, Hana Hanzlikova, Zdenek Hodny, Jiri Lukas, Jiri Bartek   +6 more
openaire   +2 more sources

Uba1: A Potential Ubiquitin-like Activator Protein of Urm1 in Toxoplasma gondii

International Journal of Molecular Sciences, 2022
We had shown in our previous study that TgUrm1 (ubiquitin-related Modifier 1) was involved in the regulation of anti-oxidant stress in Toxoplasma gondii by conjugating with TgAhp1. It is generally believed that Urm1 binds to target proteins through a mechanism involving Uba (ubiquitin-like activator protein).
Xiao, Qianqian, Li, Jinxuan, Chen, Junpeng, Tan, Qianqian, Chen, Xiao, Li, Hongmei, Zhao, Xiaomin, Zhang, Xiao   +7 more
openaire   +2 more sources

Ubiquitin-Like Modifier Activating Enzyme 1 as a Novel Diagnostic and Prognostic Indicator That Correlates With Ferroptosis and the Malignant Phenotypes of Liver Cancer Cells

Frontiers in Oncology, 2020
PurposeFerroptosis is a type of cell death that is iron dependent, a characteristic that distinguishes it from necrosis, apoptosis, and autophagy. However, the ferroptotic mechanisms for hepatitis B virus-associated hepatocellular carcinoma (HCC) remain ...
Yiru Shan, Guang Yang, Haixia Huang, Yehan Zhou, Xiangyu Hu, Qiuhong Lu, Peng Guo, Jun Hou, Li Cao, Fuhua Tian, Qi Pan, Qi Pan   +11 more
doaj   +1 more source