Results 91 to 100 of about 4,126 (198)

Distinct Pattern of Atypical Megakaryocytes in VEXAS Syndrome

International Journal of Laboratory Hematology, EarlyView.
Andrew Y. Sung, Jackson W. Douglas, Olga K. Weinberg, Sharon K. Germans, Weina Chen   +4 more
wiley   +1 more source

SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination [PDF]

, 2014
published_or_final_versio
Akasaka, Bailly, Bi, Bi, Bienko, Bienko, Callegari, Centore, Ciccia, Cohn, Davies, Davis, Du, Durando, Emanuele, Friedberg, Garg, Ghosal, Haracska, Haracska, Haracska, Haracska, Hibbert, Hoege, Huang, Huang, Iorio-Morin, Jackson, Jinhua Han, Johnson, Juhasz, Jun Huang, Kannouche, Kim, Lee, Lehmann, Lehmann, Lehmann, Lin Hu, Liu, Lopes, Machida, Maher, Masutani, Masutani, McCulloch, Michael S.Y. Huen, Moldovan, Mosbech, Ohmori, Parnas, Plosky, Povlsen, Prakash, Prasad, Resch, Sale, Schmutz, Stelter, Takahashi, Terai, Ting Liu, Unk, Unk, Wan, Wang, Watanabe, Xue, Yanagihara, Yang, Yang, Yang, Zhiqiu Chen   +72 more
core   +2 more sources

A de novo evolved gene in the house mouse regulates female pregnancy cycles

, 2019
The de novo emergence of new genes has been well documented through genomic analyses. However, a functional analysis, especially of very young protein-coding genes, is still largely lacking.
Bekpen, C., Keshavarz, M., Krebs-Wheaton, R., Künzel, S., Skrabar, N., Tautz, D., Ullrich, K., Xie, C.   +7 more
core   +1 more source

The Challenging and Unique Diagnosis of VEXAS Syndrome: A Case Report

Journal of Investigative Medicine High Impact Case Reports
VEXAS syndrome, a myeloid-driven autoinflammatory disorder associated with somatic mutations in the UBA1 gene, was first described in 2020 and presents significant diagnostic challenges due to its complex clinical features, including hematological ...
Jowan Al-Nusair, Olivia Lim, Leena Alhusari, Abdelwahap Elghezewi, Mahmoud Abdallah, Mohamed Alshal, Toni Pacioles   +6 more
doaj   +1 more source

Successful Treatment of Refractory Sweet's Syndrome With Adalimumab in a Myelodysplastic Syndrome Patient

eJHaem, Volume 7, Issue 1, February 2026.
ABSTRACT We report a 69‐year‐old man diagnosed as myelodysplastic syndrome and administrated with azacitidine and selinexor treatment. Then he was revealed high fever and multiple tender erythematous papules involving his mouth, back, upper and lower extremities, which were diagnosed as Sweet's syndrome by skin biopsy.
Liya Ma, Yaojia Shen, Jie Chang, Shanshan Suo, Lu Wang, Weifang Zhu, Jianjun Qiao, Hongyan Tong   +7 more
wiley   +1 more source

Proteomic and Ubiquitinated Proteome Insights Into ER Stress Responses in Chinese Hamster Ovary Cells Under Mild Hypothermic Conditions

Biotechnology and Bioengineering, Volume 123, Issue 1, Page 5-25, January 2026.
Proteomic analysis of CHO cells under mild hypothermia (31°C) reveals ER stress responses, ubiquitination dynamics, and adaptive mechanisms. Magnetic immuno‐affinity enrichment and mass spectrometry highlight protein regulation differences in non‐producer versus producer cells, offering insights for optimising biopharmaceutical production of IgG1 and ...
David Ryan, Christiana‐Kondylo Sideri, Michael Henry, Selvaprakash Karuppuchamy, Esen Efeoglu, Paula Meleady   +5 more
wiley   +1 more source

The profile of clinical and laboratory features of Chinese VEXAS syndrome patients with hematological abnormalities: a single-center case series

Frontiers in Immunology
ObjectivesVEXAS syndrome is a recently characterized hemato-inflammatory disorder caused by somatic mutations in the X-linked UBA1 gene in hematopoietic cells, which remains poorly characterized in Chinese populations. This study aims to address this gap.
Xiang Ren, Xiang Ren, Xiang Ren, Min Wang, Min Wang, Min Wang, Jiali Huo, Jiali Huo, Jiali Huo, Yujiao Jia, Yujiao Jia, Jigang Xiao, Jigang Xiao, Neng Nie, Neng Nie, Neng Nie, Jinbo Huang, Jinbo Huang, Jinbo Huang, Jing Zhang, Jing Zhang, Jing Zhang, Xin Zhao, Xin Zhao, Xin Zhao, Liwei Fang, Liwei Fang, Liwei Fang, Guangxin Peng, Guangxin Peng, Guangxin Peng, Li Zhang, Li Zhang, Li Zhang, Fengkui Zhang, Fengkui Zhang, Fengkui Zhang, Yizhou Zheng, Yizhou Zheng, Yizhou Zheng, Jun Shi, Jun Shi, Jun Shi, Meili Ge, Meili Ge, Meili Ge   +45 more
doaj   +1 more source

Receptor Tyrosine Kinase Ubiquitination and De-Ubiquitination in Signal Transduction and Receptor Trafficking. [PDF]

, 2018
Receptor tyrosine kinases (RTKs) are membrane-based sensors that enable rapid communication between cells and their environment. Evidence is now emerging that interdependent regulatory mechanisms, such as membrane trafficking, ubiquitination, proteolysis
Basagiannis, Girnita, Jahangiri, Lund, McGrath, Ott, Smith, Wiborg   +7 more
core   +5 more sources

Erythropoiesis in health and disease: Distinguishing defective and ineffective erythropoiesis

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Erythropoiesis is a finely regulated process ensuring continuous red blood cell production to maintain oxygen delivery. Disruptions in this process give rise to defective erythropoiesis, characterized by impaired lineage commitment and progenitor development, and ineffective erythropoiesis (IE), marked by expansion of erythroid progenitors ...
Sara El Hoss, Maria A. Lizarralde‐Iragorri, Thiago Trovati Maciel, Olivier Hermine   +3 more
wiley   +1 more source

Rare primary vasculitis: update on multiple complex diseases and the new kids on the block

Advances in Rheumatology
Systemic vasculitis is a group of rare diseases that share an essential characteristic: inflammation of blood vessel walls. This injury occurs during the disease course, but specific features vary for each entity.
Joao Gabriel Dantas, Erika Biegelmeyer, Eduarda Bonelli Zarur, Frederico Augusto Gurgel Pinheiro   +3 more
doaj   +1 more source