Results 101 to 110 of about 4,126 (198)

Functional characterization of the RNA guided DRM2 DNA methyltransferase. Research done in the Faculty of Biology UW and IBB PAS. M.Sc. Thesis Supervisor: prof. dr hab. Ewa Bartnik. [PDF]

, 2016
DNA methylation in plants is in part controlled by small RNAs. A key player in RNA directed DNA methylation (RdDM) is Domain Rearranged Methyltransferase 2 (DRM2).
Elkomy, Mohamed A. B.
core  

Mapping VEXAS‐associated and rare UBA1 variants in the United Kingdom: Insights from patient cohorts and the general population

British Journal of Haematology, Volume 208, Issue 1, Page 116-128, January 2026.
VEXAS syndrome is a late‐onset inflammatory disorder with rheumatological and haematological features. Epidemiological studies of VEXAS syndrome so far have been limited. Analysis of various UK cohorts estimates the incidence of VEXAS to be 1.51/100 000, or 171 new cases in the population of men over the age of 50 who are being investigated for myeloid
Ana Martinez Rodriguez, Leon Chang, Dorota Rowczenio, Alexandra Smith, Ebun Omoyinmi, James A. Poulter, Andrew McGregor, Sebastian Francis, Roochi Trikha, Adam Al‐Hakim, Kar Lok Kong, David G. Kent, Helen Lachmann, Austin Kulasekararaj, Catherine Cargo, Sinisa Savic   +15 more
wiley   +1 more source

Research Progress in VEXAS Syndrome

罕见病研究
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome is an adult-onset, X-linked clonal autoinflammatory disease caused by somatic mutations in the UBA1 gene, characterized by systemic inflammation accompanied by hematologic clonal ...
JIN Xianghong, XU Jin, CHEN Miao, ZHUANG Junling, SHEN Min   +4 more
doaj   +1 more source

HECTD3 mediates an HSP90-dependent degradation pathway for protein kinase clients [PDF]

, 2017
Inhibition of the ATPase cycle of the HSP90 chaperone promotes ubiquitylation and proteasomal degradation of its client proteins, which include many oncogenic protein kinases.
Li, Zhaobo, Pearl, Laurence H, Prodromou, Chrisostomos, Savic, Velibor, Zhou, Lihong   +4 more
core   +2 more sources

Oral mucosal manifestations with identical mutations to the bone marrow in a patient with VEXAS syndrome

Rheumatology &Autoimmunity, Volume 6, Issue 1, Page 60-62, March 2026.
Lilian Vasaitis, Lena Blomstrand, Tatjana Pandzic, Miklos Gulyas, Panagiotis Baliakas, Viktor Ljungström   +5 more
wiley   +1 more source

Understanding Myelodysplasia and Inflammation Through the Lense of VEXAS Syndrome: A Review

Cells
VEXAS syndrome, a monogenic X-linked disorder resulting from mutations in the UBA1 gene, has emerged as a key model for unraveling the links between systemic inflammatory or autoimmune diseases (SIAD) and myelodysplastic syndromes (MD).
Louis Wolff, Leo Caratsch, Lin-Pierre Zhao, Sabine Blum, Denis Comte   +4 more
doaj   +1 more source

Mechanism and disease-association of E2 conjugating enzymes:lessons from UBE2T and UBE2L3 [PDF]

, 2016
Ubiquitin signalling is a fundamental eukaryotic regulatory system, controlling diverse cellular functions. A cascade of E1, E2, and E3 enzymes is required for assembly of distinct signals, whereas an array of deubiquitinases and ubiquitin-binding ...
Alfano, Ali, Alpi, Alpi, Alter, Arno F. Alpi, Benirschke, Berndsen, Bogliolo, Boisson, Boisson, Brzovic, Buetow, Burroughs, Cantor, Ceccaldi, Charan, Chaugule, Chiu, Chong, Christensen, Christensen, Ciccia, Clague, Clague, Cole, Cook, Corson, Das, Das, Dawson, Devine, Dorsman, Dou, Dou, Dove, Dubois, Duda, Duxin, Eddins, Eletr, Eletr, Enchev, Fiesel, Flotho, Franke, Galanty, Gao, Garaycoechea, Garcia-Higuera, Gateva, Geisler, Gerlach, Grishin, Hamilton, Han, Hao, Hasebe, Hatakeyama, Heideker, Helen Walden, Hibbert, Hinks, Hira, Hodson, Hodson, Hu, Huang, Huang, Husnjak, Iguchi, Ikeda, Jin, Jostins, Juang, Kamadurai, Kane, Kar, Kazlauskaite, Kelsall, Kelsall, Kim, Kirisako, Kitada, Kondapalli, Koyano, Kulathu, Kumar, Kumar, Kumari, Langevin, Lechtenberg, Lewis, Li, Li, Li, Ling, Liu, Lobitz, Lopez-Martinez, Lorenz, Loveday, Mace, Machida, Mackay, Markson, Maure, McGinty, Meetei, Meetei, Meetei, Meindl, Metzger, Metzger, Michelle, Middleton, Mosedale, Mulder, Nakada, Nascimento, Nuber, Orozco, Page, Pao, Parker, Peltzer, Pelzer, Perkins, Petroski, Pickart, Plechanovová, Pontel, Pruneda, Pruneda, Rahman, Rajendra, Ravid, Rickard, Rickman, Rodrigo-Brenni, Rodrigo-Brenni, Ronchi, Rosado, Roy, Saha, Sarcevic, Scheffner, Schulman, Schumacher, Shchebet, Sheng, Sims, Singh, Sloper-Mould, Smogorzewska, Spratt, Spratt, Stahl, Stewart, Stieglitz, Streich, Sun, Tatham, Tokunaga, Trempe, Tsoi, Turco, Ueki, Valimberti, van Wijk, van Wijk, Viduth Chaugule, Virts, Vittal, Voutsadakis, Wang, Wang, Wang, Wauer, Wen, Wenzel, Wickliffe, Wiener, Windheim, Wood, Wooster, Xu, Yan, Yang, Yin, Yu, Zhang, Ziemba   +192 more
core   +5 more sources

Safety and effectiveness of the combination of 5‐azacitidine and ruxolitinib in VEXAS syndrome: A single‐centre experience

British Journal of Haematology, Volume 208, Issue 3, Page 1133-1137, March 2026.
Gregorio Maria Bergonzi, Enrico Cozzo, Alessandro Tomelleri, Costanza Piccolo, Gianluca Scorpio, Carmelo Gurnari, Francesca Romano, Marco Matucci‐Cerinic, Lorenzo Dagna, Massimo Bernardi, Luca Vago, Fabio Ciceri, Corrado Campochiaro, Elisa Diral   +13 more
wiley   +1 more source

An Apicoplast Localized Ubiquitylation System Is Required for the Import of Nuclear-encoded Plastid Proteins

, 2015
Apicomplexan parasites are responsible for numerous important human diseases including toxoplasmosis, cryptosporidiosis, and most importantly malaria.
Agrawal, Swati, Brooks, Carrie F., Chung, Duk-Won D., Ferdig, Michael T., Le Roch, Karine G., Ponts, Nadia, Prudhomme, Jacques, Rodrigues, Elisadra M., Striepen, Boris, Tan, John C., van Dooren, Giel G.   +10 more
core   +1 more source

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4 [PDF]

, 2014
The small ubiquitin-like modifier (SUMO) can form polymeric chains that are important signals in cellular processes such as meiosis, genome maintenance and stress response.
A Hershko, A Plechanovova, A Plechanovova, A Rojas-Fernandez, AM Weissman, AT Brunger, AT Namanja, CC Chang, CH Cheng, CM Hecker, CM Pickart, CW Liew, D Reverter, E Escobar-Cabrera, ES Johnson, F Ikeda, FM Lin, GNB Yip, H Sun, HD Ulrich, HY Sun, I Matic, J Marchant, J Prudden, J Song, J Song, J Xia, JD Schnell, JH Hurley, JL Battiste, JS Thrower, K Keusekotten, L Deng, M Ottiger, M Zweckstetter, MH Tatham, MH Tatham, MJ Eddins, MJ Eddins, MR Hansen, MS Rodriguez, N Sekiyama, N Zhang, O Kerscher, O Kerscher, Q Wang, R Bruderer, R Lescasse, R Mahajan, R Varadan, RT Hay, S-R Tzeng, SC Panchal, W Rieping, W-C Huang, XD Zhang, Y Shen, Y Xie   +57 more
core   +4 more sources