The Lysine Deprotonation Mechanism in a Ubiquitin Conjugating Enzyme. [PDF]
J Phys Chem BUbiquitination is a biochemical reaction in which a small protein, ubiquitin (Ub), is covalently linked to a lysine on a target protein. This type of post-translational modification can signal for protein degradation, DNA repair, or inflammation response.
Wathan AJ +3 more
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Ubiquitin-Conjugating Enzymes in Cancer [PDF]
Cells, 2021 The ubiquitin-mediated degradation system is responsible for controlling various tumor-promoting processes, including DNA repair, cell cycle arrest, cell proliferation, apoptosis, angiogenesis, migration and invasion, metastasis, and drug resistance. The
Quyen Thu Bui +4 more
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Unraveling the Role of Ubiquitin-Conjugating Enzyme UBE2T in Tumorigenesis: A Comprehensive Review [PDF]
CellsUbiquitin-conjugating enzyme E2 T (UBE2T) is a crucial E2 enzyme in the ubiquitin-proteasome system (UPS), playing a significant role in the ubiquitination of proteins and influencing a wide range of cellular processes, including proliferation ...
Chang Gao +7 more
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The role of ubiquitin-conjugating enzyme in the process of spermatogenesis [PDF]
Reproductive Biology and EndocrinologyThe ubiquitination is crucial for controlling cellular homeostasis and protein modification, in which ubiquitin-conjugating enzyme (E2) acts as the central player in the ubiquitination system.
Peng Lv, Jihong Liu, Xiaming Liu
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Ubiquitin-conjugating enzyme E2C (UBE2C) is a prognostic indicator for cholangiocarcinoma [PDF]
European Journal of Medical Research, 2023 Cholangiocarcinoma is the most common malignant bile duct tumor in Southeast Asia. The special location of cholangiocarcinoma leads to it being difficult to diagnose.
Khaa Hoo Ong +10 more
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The Ubiquitin Conjugating Enzyme UbcD1 is Required for Notch Signaling Activation During Drosophila Wing Development [PDF]
Frontiers in Genetics, 2021 Notch signaling pathway plays crucial roles in animal development. Protein ubiquitination contributes to Notch signaling regulation by governing the stability and activity of major signaling components.
Fengchao Zhang +3 more
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Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3 [PDF]
MedCommPeriodontitis is a chronic periodontal inflammatory disease caused by periodontal pathogens commonly seen in adults. Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a potential drug ...
Wenhua Kuang +14 more
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Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c
Acta Pharmaceutica Sinica B, 2017 UbcH5c belongs to the ubiquitin-conjugating enzyme family and plays an important role in catalyzing ubiquitination during TNF-α--triggered NF-κB activation. Therefore, UbcH5c is a potent therapeutic target for the treatment of inflammatory and autoimmune
Fangshu Wu +3 more
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miR-379-5p affects breast cancer cell behavior by targeting UBE2E3 ubiquitin conjugating enzyme. [PDF]
PLoS ONEMicroRNAs (miRNAs) play an increasingly recognized role in modulating cancer development. Due to their function in regulating gene expression, miRNAs can suppress or promote tumorigenesis. miR-379-5p expression is downregulated in multiple human cancers,
Araya K Schroder +5 more
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