Results 101 to 110 of about 27,627 (205)

Strangers in a foreign land: 'Yeastizing' plant enzymes [PDF]

arXiv
Expressing plant metabolic pathways in microbial platforms is an efficient, cost-effective solution for producing many desired plant compounds. As eukaryotic organisms, yeasts are often the preferred platform. However, expression of plant enzymes in a yeast frequently leads to failure because the enzymes are poorly adapted to the foreign yeast cellular
arxiv  

A series of xanthenes inhibiting Rad6 function and Rad6-Rad18 interaction in the PCNA ubiquitination cascade

iScience, 2022
Summary: Ubiquitination of proliferating cell nuclear antigen (PCNA) triggers pathways of DNA damage tolerance, including mutagenic translesion DNA synthesis, and comprises a cascade of reactions involving the E1 ubiquitin-activating enzyme Uba1, the E2 ...
Gabriel Fenteany, Gaurav Sharma, Paras Gaur, Attila Borics, Edit Wéber, Ernő Kiss, Lajos Haracska   +6 more
doaj  

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain [PDF]

, 2000
Li Deng, Chen Wang, Erika Spencer, Liyong Yang, Amy Braun, Jianxin You, Clive A. Slaughter, Cecile M. Pickart, Zhijian J. Chen   +8 more
openalex   +1 more source

The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin

Neurobiology of Disease, 2018
Huntington's disease (HD) is caused by a CAG repeat expansion that encodes a polyglutamine (polyQ) expansion in the HD disease protein, huntingtin (HTT). PolyQ expansion promotes misfolding and aggregation of mutant HTT (mHTT) within neurons.
Bo Wang, Li Zeng, Sean A. Merillat, Svetlana Fischer, Joseph Ochaba, Leslie M. Thompson, Sami J. Barmada, Kenneth M. Scaglione, Henry L. Paulson   +8 more
doaj  

IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation. [PDF]

Nat Commun, 2023
Mishra V, Crespo-Puig A, McCarthy C, Masonou T, Glegola-Madejska I, Dejoux A, Dow G, Eldridge MJG, Marinelli LH, Meng M, Wang S, Bennison DJ, Morrison R, Shenoy AR.   +13 more
europepmc   +1 more source

Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase [PDF]

, 2000
Françoise Reymond, C Wirbelauer, Wilhelm Krek   +2 more
openalex   +1 more source

Rice ubiquitin-conjugating enzyme OsUbc13 negatively regulates immunity against pathogens by enhancing the activity of OsSnRK1a. [PDF]

Plant Biotechnol J, 2023
Liu J, Nie B, Yu B, Xu F, Zhang Q, Wang Y, Xu W.   +6 more
europepmc   +1 more source

Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9 [PDF]

, 2000
Yufei Shi, Minjing Zou, Nadir R. FARID, Malcolm C. Paterson   +3 more
openalex   +1 more source

Reaction-conditioned De Novo Enzyme Design with GENzyme [PDF]

arXiv
The introduction of models like RFDiffusionAA, AlphaFold3, AlphaProteo, and Chai1 has revolutionized protein structure modeling and interaction prediction, primarily from a binding perspective, focusing on creating ideal lock-and-key models. However, these methods can fall short for enzyme-substrate interactions, where perfect binding models are rare ...
arxiv  

Ubiquitin-Conjugating Enzyme OsUBC11 Affects the Development of Roots via Auxin Pathway. [PDF]

Rice (N Y), 2023
Han Y, Zhang C, Sha H, Wang X, Yu Y, Liu J, Zhao G, Wang J, Qiu G, Xu X, Fang J.   +10 more
europepmc   +1 more source