Results 101 to 110 of about 91,428 (363)

Aged monkey brains reveal the role of ubiquitin-conjugating enzyme UBE2N in the synaptosomal accumulation of mutant huntingtin.

Human Molecular Genetics, 2015
Although misfolded proteins are ubiquitinated and cleared by the proteasome, they can accumulate in synapses in aged neurons to promote synaptic dysfunction in a variety of neurodegenerative diseases, including Huntington's disease (HD), which is caused ...
Peng Yin, Zhuchi Tu, An Yin, Ting Zhao, Sen Yan, Xiangyu Guo, Renbao Chang, L. Zhang, Yan Hong, Xiahe Huang, Jun Zhou, Yingchun Wang, Shihua Li, Xiao-Jiang Li   +13 more
semanticscholar   +1 more source

Current trends in single‐cell RNA sequencing applications in diabetes mellitus

FEBS Open Bio, EarlyView.
Single‐cell RNA sequencing is a powerful approach to decipher the cellular and molecular landscape at a single‐cell resolution. The rapid development of this technology has led to a wide range of applications, including the detection of cellular and molecular mechanisms and the identification and introduction of novel potential diagnostic and ...
Seyed Sajjad Zadian, Khodakaram Jahanbin, Shekoofeh Nikooei, Marzieh Rostaminejad, Arezoo Rahimi, Pedram Abdizadeh, Behnam Alipoor   +6 more
wiley   +1 more source

Regulation of lysosome integrity and lysophagy by the ubiquitin-conjugating enzyme UBE2QL1 [PDF]

Autophagy, 2019
Lysosomal membrane permeabilization or full rupture of lysosomes is a common and severe stress condition that is relevant for degenerative disease, infection and cancer. Cells respond with extensive ubiquitination of damaged lysosomes, which triggers selective macroautophagy/autophagy of the whole organelle, termed lysophagy.
Bojana Kravic, Christian Behrends, Hemmo Meyer   +2 more
openaire   +4 more sources

Ubiquitylation in ERAD: reversing to go forward? [PDF]

PLoS Biology, 2011
Proteins are co-translationally inserted into the endoplasmic reticulum (ER) where they undergo maturation. Homeostasis in the ER requires a highly sensitive and selective means of quality control.
Yien Che Tsai, Allan M Weissman
doaj   +1 more source

Inhibition of Ubc13-mediated ubiquitination by GPS2 regulates multiple stages of B cell development [PDF]

, 2016
Non-proteolytic ubiquitin signaling mediated by Lys63 ubiquitin chains plays a critical role in multiple pathways that are key to the development and activation of immune cells.
Aggarwal, Akira, Allman, Amanda Lopacinski, Anna C. Belkina, Baer, Banerji, Barbara S. Nikolajczyk, Bhoj, Bianchi, Bogdan Tanasa, Branigan, Cardamone, Cardamone, Cariappa, Carly T. Cederquist, Cederquist, Chen, Chen, Cheng, Chow, Chu, Chun, Cilloni, Ciriello, Claudia Lentucci, Compagno, Coornaert, Davis, DeFuria, Dengler, Diederichs, Dunne, Fabris, Fan, Flemming, Giltiay, Guo, Habelhah, Haslinger, Hayden, Ho, Holly E. Johnson, Honma, Horikawa, Ikeda, Iwai, Jakobsson, Jennifer Snyder-Cappione, Jiang, Jiang, Jin, Jin, Juang, Jumaa, Karin, Kato, Katz, Kobayashi, Kotecha, Landmann, Langmead, Lee, Lee, Li, Lino, Liu, M. Dafne Cardamone, Malynn, Marchant, Maspero, Michelle Chan, Minegishi, Moran, Nagy, Notley, Ochiai, Oeckinghaus, Ori, Panda, Pappu, Peng, Peng, Pickart, Pillai, Popovic, Pruneda, Pugh, Pulvino, Qiu, Rickert, Ruland, Saito, Sanyal, Sato, Schmidt-Supprian, Shah, Sherry Prasad, Skaug, Spain, Stefano Monti, Stephens, Stringer, Sun, Sun, Szydlowski, Tavares, Toubal, Touma, Valentina Perissi, Venteclef, Wang, Wasserman, Weigert, Wiener, Witt, Wu, Yamamoto, Yang, Yao, Zhang, Zhang, Zhang   +122 more
core   +1 more source

The ubiquitin-conjugating enzyme UBE2E3 and its import receptor importin-11 regulate the localization and activity of the antioxidant transcription factor NRF2

Molecular Biology of the Cell, 2015
This study describes a novel regulatory pathway for the master antioxidant transcription factor Nrf2. The ubiquitin-conjugating enzyme UBE2E3 and its nuclear transport receptor importin-11 coordinately promote the transcriptional activity of Nrf2 by ...
Kendra S. Plafker, S. Plafker
semanticscholar   +1 more source

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

Proceedings of the National Academy of Sciences of the United States of America, 1999
A RING finger-containing protein (AO7) that binds ubiquitin-conjugating enzymes (E2s) and is a substrate for E2-dependent ubiquitination was identified.
K. Lorick, J. P. Jensen, Shengyun Fang, A. Ong, S. Hatakeyama, A. Weissman   +5 more
semanticscholar   +1 more source

Acod1 Promotes PAD4 Ubiquitination via UBR5 Alkylation to Modulate NETosis and Exert Protective Effects in Sepsis

Advanced Science, EarlyView.
In this study, Acod1 knockout in CLP mice significantly increases peripheral blood NET levels, exacerbating inflammation, organ damage, and reducing survival. Further research shows that UBR5 interacts with PAD4, a key NET formation protein. Acod1/itaconate (ITA) enhances the enzymatic activity of UBR5 by alkylating the Cys2768 site, promoting the K48 ...
Huifan Liu, Guoqing Jing, Shujuan Wu, Min Yuan, Yingyue Dong, Xue Chen, Huimin Zhou, Hailong Gong, Jing Zuo, Xiaojing Wu, Xuemin Song   +10 more
wiley   +1 more source

E2 ubiquitin-conjugating enzymes regulate the deubiquitinating activity of OTUB1 [PDF]

Nature Structural & Molecular Biology, 2013
OTUB1 is a Lys48-specific deubiquitinating enzyme that forms a complex in vivo with E2 ubiquitin (Ub)-conjugating enzymes including UBC13 and UBCH5. OTUB1 binds E2~Ub thioester intermediates and prevents ubiquitin transfer, thereby noncatalytically inhibiting accumulation of polyubiquitin.
Michael J. Matunis, Xiangbin Zhang, Xiangbin Zhang, Cynthia Wolberger, Cynthia Wolberger, Reuven Wiener, Catherine M. Guzzo, Anthony T DiBello, Anthony T DiBello, Patrick M. Lombardi, Patrick M. Lombardi   +10 more
openaire   +3 more sources