Results 111 to 120 of about 30,210 (297)

Role of the C‐terminus of Saccharomyces cerevisiae ubiquitin‐conjugating enzyme (Rad6) in substrate and ubiquitin‐protein‐ligase (E3‐R) interactions [PDF]

, 1994
Bilha Raboy, Richard G. Kulka
openalex   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Regulation of Ubiquitin-conjugating Enzymes by Glutathione Following Oxidative Stress [PDF]

, 1997
Jessica Jahngen-Hodge, Martin S. Obin, Xin Gong, Fu Shang, Thomas Nowell, Junxian Gong, Hajiya Abasi, Jeffrey B. Blumberg, Allen Taylor   +8 more
openalex   +1 more source

UBC13 is an RNF213‐associated E2 ubiquitin‐conjugating enzyme, and Lysine 63‐linked ubiquitination by the RNF213‐UBC13 axis is responsible for angiogenic activity

, 2021
Toshiyuki Habu, Kouji H. Harada
openalex   +1 more source

Microcystin‐LR Triggers Renal Tubular Ferroptosis Through Epigenetic Repression of GPX4: Implications for Environmental Nephrotoxicity

Advanced Science, EarlyView.
MC‐LR stabilizes DNMT1/3a by blocking their ubiquitin‐mediated degradation, leading to Gpx4 promoter hypermethylation and E2F4/NCoR‐associated transcriptional repression, which drives renal tubular ferroptosis in mice. Pharmacological inhibition of DNA methylation (SGI‐1027) or ferroptosis (Fer‐1) disrupts this DNMT‐GPX4 axis, thereby alleviating MC‐LR‐
Shaoru Zhang, Qi Gao, Yi Peng, Huan Zhang, Qi Shen, Meihong Guo, Yuqing Gong, Lei Chu, Weidong Wu, Yanting Wen, Wangsen Cao, Yong Wang, Lihui Wang   +12 more
wiley   +1 more source

Targeting histone deacetylase 4/ubiquitin‐conjugating enzyme 9 impairs DNA repair for radiosensitization of hepatocellular carcinoma cells in mice [PDF]

, 2017
Chiao‐Ling Tsai, Weilin Liu, Feng‐Ming Hsu, Po‐Sheng Yang, Ruoh‐Fang Yen, Kai‐Yuan Tzen, Ann‐Lii Cheng, Pei‐Jer Chen, Jason Chia‐Hsien Cheng   +8 more
openalex   +1 more source

A20 Facilitates Oxaliplatin Sensitivity in Colorectal Cancer Through Monoubiquitylation of IKK‐β

Advanced Science, EarlyView.
This study demonstrates that the expression of A20, a ubiquitin‐editing enzyme, is positively correlated with oxaliplatin sensitivity in colorectal cancer (CRC). Mechanistically, A20 enhances oxaliplatin sensitivity by inhibiting NF‐κB nuclear translocation through monoubiquitination of IKK‐β.
Fan Luo, Ting Yang, Jiaxin Cao, Qun Chen, Zhenhai Lu, Feiteng Lu, Chaozhuo Lin, Zengfei Xia, Yuanzhong Yang, Peng Li, Wenjuan Ma, Min Luo, Rongxin Zhang   +12 more
wiley   +1 more source

Inhibition of UBE2C Promotes Parkin‐Mediated K63‐Linked Ubiquitination of TOP2A to Induce Senescence and Increase Sensitivity of Doxorubicin in Breast Cancer

Advanced Science
Breast cancer is now the second most commonly diagnosed cancer and the most common female malignancy. Chemotherapy‐based adjuvant therapy after surgery and neoadjuvant therapy before surgery are cornerstones of breast cancer treatment. Doxorubicin is one
Yihui Yang, Wan Li, Hong Yang, Fang Xu, Sen Zhang, Wanxin Cao, Xiaoxue Li, Xu Zhang, Xiangyin Chi, Hongquan Wang, Guanhua Du, Yumin Wang, Jinhua Wang   +12 more
doaj   +1 more source

Elevated growth temperature decreases levels of the PEX5 peroxisome-targeting signal receptor and ameliorates defects of Arabidopsis mutants with an impaired PEX4 ubiquitin-conjugating enzyme [PDF]

, 2015
Yun‐Ting Kao, Bonnie Bartel
openalex   +1 more source

ABCF1 is a novel E2 ubiquitin-conjugating enzyme that controls Toll-like receptor-mediated innate immune responses and cytokine storm during sepsis

, 2021
Hitesh Arora
openalex   +1 more source