Results 121 to 130 of about 91,428 (363)

Regulation of p53 by the Ubiquitin-conjugating Enzymes UbcH5B/C in Vivo [PDF]

Journal of Biological Chemistry, 2004
p53 levels are regulated by ubiquitination and 26 S proteasome-mediated degradation. p53 is a substrate for the E3 ligase Mdm2, however, the ubiquitin-conjugating enzymes (E2s) involved in p53 ubiquitination in intact cells have not been defined previously.
Saville, Mark K., Sparks, Alison, Xirodimas, Dimitris P., Wardrop, Julie, Stevenson, Lauren F., Bourdon, Jean-Christophe, Woods, Yvonne L., Lane, David P.   +7 more
openaire   +4 more sources

SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities [PDF]

, 1997
Traversal from G1 to S-phase in cycling cells of budding yeast is dependent on the destruction of the S-phase cyclin/CDK inhibitor SIC1. Genetic data suggest that SIC1 proteolysis is mediated by the ubiquitin pathway and requires the action of CDC34 ...
Deshaies, Raymond J., Feldman, R. M. Renny, Verma, Rati   +2 more
core  

Ubiquitin-conjugating Enzyme Cdc34 and Ubiquitin Ligase Skp1-Cullin-F-box Ligase (SCF) Interact through Multiple Conformations*

Journal of Biological Chemistry, 2014
Background: The ubiquitin-conjugating enzyme Cdc34 rapidly associates with ubiquitin ligase SCF to achieve processive ubiquitination. Results: Protein cross-linking was used to capture native Cdc34-SCF complexes.
Daniella Sandoval, Spencer Hill, A. Ziemba, Steven M. Lewis, B. Kuhlman, Gary Kleiger   +5 more
semanticscholar   +1 more source

Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA

Advanced Science, EarlyView.
Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin, Runyu Cao, Xuemei Bai, Jiahua Yuan, Wanwei Sun, Yi Zheng, Xiaopeng Qi, Wei Zhao, Bingyu Liu, Chengjiang Gao   +9 more
wiley   +1 more source

The Ubc3 (Cdc34) Ubiquitin-Conjugating Enzyme Is Ubiquitinated and Phosphorylated In Vivo [PDF]

Molecular and Cellular Biology, 1994
The transition from G1 to S phase of the cell cycle in Saccharomyces cerevisiae requires the activity of the Ubc3 (Cdc34) ubiquitin-conjugating enzyme. S. cerevisiae cells lacking a functional UBC3 (CDC34) gene are able to execute the Start function that initiates the cell cycle but fail to form a mitotic spindle or enter S phase.
Breck Byers, Loretta Goetsch, Mark G. Goebl   +2 more
openaire   +3 more sources

Combinatory effect of BRCA1 and HERC2 expression on outcome in advanced non-small-cell lung cancer [PDF]

, 2016
BACKGROUND: BRCA1 is a main component of homologous recombination and induces resistance to platinum in preclinical models. It has been studied as a potential predictive marker in lung cancer. Several proteins modulate the function of BRCA1.
Bonanno, Laura, Costa Ribalta, Carlota, Favaretto, Adolfo, Gimenez-Capitan, Ana, Majem, Margarita, Massuti, Bartomeu, Molina-Vila, Miquel Angel, Pallares, Cinta, Rodriguez, Ignacio, Rosell, Rafael, Rugge, Massimo, Sanchez, Jose-Javier, Taron, Miquel, Universitat Autònoma de Barcelona, Vergnenegre, Alain   +14 more
core   +8 more sources

Natural Allelic Variations in IbCHYR1–IbZnFR Complex Regulate Fusarium Root Rot Resistance in Sweet Potato

Advanced Science, EarlyView.
FfRlpA2, a conserved Fusarium effector, functions as a protease inhibitor by hijacking the E3 ubiquitin ligase IbCHYR1 to degrade the resistance factor IbZnFR, thereby promoting Fusarium pathogenicity. Conversely, the high dosage Pro::IbZnFRHap2 allele was associated with resistance to root rot disease.
Huan Zhang, Zhuoru Dai, Xiaochen Zhang, Meiqi Shang, Xiaoru Gao, Ruiqi Ma, Limeng Zhao, Xiaoli Zhang, Qingchang Liu, Hong Zhai, Shaopei Gao, Ning Zhao, Qinghe Cao, Qiang Li, Shaozhen He   +14 more
wiley   +1 more source

Deciphering the substrate specificity of ubiquitin conjugating enzymes

, 2014
Presentation of my 3rd rotation project on the Wellcome Trust PhD programme. Work supervised by Prof. Ronald T. Hay (Gene Regulation and Expression, College of Life Sciences, University of Dundee).
Madeira, Fábio, Hay, Ronald T.
openaire   +2 more sources

Enhancing Specificity, Precision, Accessibility, Flexibility, and Safety to Overcome Traditional CRISPR/Cas Editing Challenges and Shape Future Innovations

Advanced Science, EarlyView.
CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi, Mohamed Ramadan, Lu Yu, Fengjiao Hui, Amjad Hussain, Xiaofeng Zhou, Yu Yu, Xianlong Zhang, Shuangxia Jin   +8 more
wiley   +1 more source

A human ubiquitin-conjugating enzyme homologous to yeast UBC8.

Journal of Biological Chemistry, 1994
Ubiquitin-conjugating enzymes catalyze the covalent attachment of ubiquitin to cellular substrates. Here we describe the isolation of a novel ubiquitin-conjugating enzyme from human placenta and the cloning of the corresponding cDNA. DNA sequencing revealed that this gene, UbcH2, encodes a protein with significant sequence similarity to yeast UBC8.
Peter K. Kaiser, L. Hofferer, C Sachsenmaier, Rainer Schneider, Barbara Kofler, Wolfgang Seufert, Stefan Jentsch, Herbert Herzog, Manfred Schweiger   +8 more
openaire   +3 more sources