Results 141 to 150 of about 91,428 (363)

Posttranslational modifications of GLUT4 affect its subcellular localization and translocation [PDF]

, 2013
The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast ...
Bayer, Begum, Birnbaum, Bogan, Bogan, Bogan, Bryant, Cassie Welburn, Chang, Fujita, Garvey, Gill, Giorgino, Govers, Grasbon-Frodl, Gwyn Gould, Haga, Hardy, Herrmann, Hicke, Huang, Ing, James, James, Jessica Sadler, Jeyaraj, Karylowski, Kupriyanova, Lamb, Lau, Lawrence, Lawrence, Leto, Li, Liu, Livingstone, Mahajan, Marsh, Marshall, Marshall, Martin, Matunis, McCormick, Muller, Nia Bryant, Perera, Pessin, Pilch, Piper, Ren, Reusch, Saltiel, Semiz, Shi, Shi, Stöckli, Toh, Urbe, Vannucci, Varki, Watson, Williams, Yang, Yu, Zaarour   +64 more
core   +3 more sources

Novel Inhibitors of Rad6 Ubiquitin Conjugating Enzyme: Design, Synthesis, Identification, and Functional Characterization

Molecular Cancer Therapeutics, 2013
Protein ubiquitination is important for cell signaling, DNA repair, and proteasomal degradation, and it is not surprising that alterations in ubiquitination occur frequently in cancer.
M. Sanders, Ghali Brahemi, P. Nangia-Makker, V. Balan, M. Morelli, Hend Kothayer, A. Westwell, M. Shekhar   +7 more
semanticscholar   +1 more source

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source

Mechanism and disease-association of E2 conjugating enzymes:lessons from UBE2T and UBE2L3 [PDF]

, 2016
Ubiquitin signalling is a fundamental eukaryotic regulatory system, controlling diverse cellular functions. A cascade of E1, E2, and E3 enzymes is required for assembly of distinct signals, whereas an array of deubiquitinases and ubiquitin-binding ...
Alfano, Ali, Alpi, Alpi, Alter, Arno F. Alpi, Benirschke, Berndsen, Bogliolo, Boisson, Boisson, Brzovic, Buetow, Burroughs, Cantor, Ceccaldi, Charan, Chaugule, Chiu, Chong, Christensen, Christensen, Ciccia, Clague, Clague, Cole, Cook, Corson, Das, Das, Dawson, Devine, Dorsman, Dou, Dou, Dove, Dubois, Duda, Duxin, Eddins, Eletr, Eletr, Enchev, Fiesel, Flotho, Franke, Galanty, Gao, Garaycoechea, Garcia-Higuera, Gateva, Geisler, Gerlach, Grishin, Hamilton, Han, Hao, Hasebe, Hatakeyama, Heideker, Helen Walden, Hibbert, Hinks, Hira, Hodson, Hodson, Hu, Huang, Huang, Husnjak, Iguchi, Ikeda, Jin, Jostins, Juang, Kamadurai, Kane, Kar, Kazlauskaite, Kelsall, Kelsall, Kim, Kirisako, Kitada, Kondapalli, Koyano, Kulathu, Kumar, Kumar, Kumari, Langevin, Lechtenberg, Lewis, Li, Li, Li, Ling, Liu, Lobitz, Lopez-Martinez, Lorenz, Loveday, Mace, Machida, Mackay, Markson, Maure, McGinty, Meetei, Meetei, Meetei, Meindl, Metzger, Metzger, Michelle, Middleton, Mosedale, Mulder, Nakada, Nascimento, Nuber, Orozco, Page, Pao, Parker, Peltzer, Pelzer, Perkins, Petroski, Pickart, Plechanovová, Pontel, Pruneda, Pruneda, Rahman, Rajendra, Ravid, Rickard, Rickman, Rodrigo-Brenni, Rodrigo-Brenni, Ronchi, Rosado, Roy, Saha, Sarcevic, Scheffner, Schulman, Schumacher, Shchebet, Sheng, Sims, Singh, Sloper-Mould, Smogorzewska, Spratt, Spratt, Stahl, Stewart, Stieglitz, Streich, Sun, Tatham, Tokunaga, Trempe, Tsoi, Turco, Ueki, Valimberti, van Wijk, van Wijk, Viduth Chaugule, Virts, Vittal, Voutsadakis, Wang, Wang, Wang, Wauer, Wen, Wenzel, Wickliffe, Wiener, Windheim, Wood, Wooster, Xu, Yan, Yang, Yin, Yu, Zhang, Ziemba   +192 more
core   +5 more sources

Ubiquitin-specific Protease 7 Is a Regulator of Ubiquitin-conjugating Enzyme UbE2E1*

Journal of Biological Chemistry, 2013
Background: USP7 is a ubiquitin-specific protease that regulates the turnover of target proteins in the cell. Results: UbE2E1 was identified to interact with USP7 through its ASTS motif.
Feroz Sarkari, K. Wheaton, Anthony La Delfa, Majda Mohamed, Faryal Shaikh, R. Khatun, C. Arrowsmith, L. Frappier, V. Saridakis, Y. Sheng   +9 more
semanticscholar   +1 more source

Irisin Attenuates Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension via Ubiquitin‐Mediated Regulation of ENO1

Advanced Science, EarlyView.
Irisin is a crucial plasma biomarker and promising therapeutic target that reflects disease severity, pulmonary vascular remodeling status and clinical outcome in patients with pulmonary arterial hypertension (PAH). As a novel protective factor, irisin is downregulated in PAH. By ubiquitination, irisin promotes Enolase 1 degradation and suppresses cell
Na Sun, Yong‐Bing Wang, Jing Huang, Run‐Wei Deng, Hui‐Yu He, Lei Gao, Xuan Gao, You‐Li Fan, Yan Cong, Yao‐Lei Guo, Yi‐Qiang Chen, Gui‐Jia Wang, Shao‐Hong Fang, Xia Gu, Bo Yu, Bing‐Xiang Wu   +15 more
wiley   +1 more source

Legionella effector MavC targets the Ube2N~Ub conjugate for noncanonical ubiquitination

Nature Communications, 2020
The Legionella pneumophila effector MavC inhibits the human ubiquitin-conjugating enzyme Ube2N. Here, the authors combine NMR, X-ray crystallography and biochemical assays and show that MavC catalyses the intramolecular transglutaminase reaction between ...
Kedar Puvar, Shalini Iyer, Jiaqi Fu, Sebastian Kenny, Kristos I. Negrón Terón, Zhao-Qing Luo, Peter S. Brzovic, Rachel E. Klevit, Chittaranjan Das   +8 more
doaj   +1 more source

Dissecting Distinct Roles of NEDDylation E1 Ligase Heterodimer APPBP1 and UBA3 Reveals Potential Evolution Process for Activation of Ubiquitin-related Pathways. [PDF]

, 2018
Despite the similar enzyme cascade in the Ubiquitin and Ubiquitin-like peptide(Ubl) conjugation, the involvement of single or heterodimer E1 activating enzyme has been a mystery.
Gaieb, Zied, Kung, Raphael, Le, Frank, Liao, Jiayu, Malik-Chaudhry, Harbani Kaur, Morikis, Dimitrios, Reyes, Michael, Saavedra, Amanda   +7 more
core  

The MALDI TOF E2/E3 ligase assay as universal tool for drug discovery in the ubiquitin pathway [PDF]

, 2017
In many diseases, components of the ubiquitin system - such as E2/E3 ligases and deubiquitylases - are dysregulated. The ubiquitin system has therefore become an emergent target for the treatment of a number of diseases, including cancer ...
Barlow, Victoria, De Cesare, Virginia, Hastie, Charles, Johnson, Clare, Knebel, Axel, Trost, Matthias   +5 more
core   +4 more sources

The Ubiquitin-conjugating Enzyme (E2) Ube2w Ubiquitinates the N Terminus of Substrates*

Journal of Biological Chemistry, 2013
Background: Some proteins are ubiquitinated on their N terminus, yet the enzymes that facilitate N-terminal ubiquitination are unknown. Results: Ube2w has a novel active site and ubiquitinates the N terminus of substrates.
K. Scaglione, V. Basrur, Naila S. Ashraf, John R. Konen, K. Elenitoba-Johnson, Sokol V. Todi, H. Paulson   +6 more
semanticscholar   +1 more source