Results 11 to 20 of about 91,279 (227)
Journal of Biological Chemistry, 2012 Background: A deubiquitinating enzyme OTUB1 inhibits Lys-63-linked ubiquitination by binding to a ubiquitin-conjugating enzyme UBC13. Results: A mechanism of human OTUB1-UBC13 interaction was revealed by human OTUB1-UBC13-MMS2 complex structure and ...
Yusuke Sato +6 more
openalex +2 more sources
Fission yeast 26S proteasome mutants are multi-drug resistant due to stabilization of the pap1 transcription factor [PDF]
, 2012 Here we report the result of a genetic screen for mutants resistant to the microtubule poison methyl benzimidazol-2-yl carbamate (MBC) that were also temperature sensitive for growth.
A Varshavsky +28 more
core +18 more sources
Targeting neddylation E2s: a novel therapeutic strategy in cancer
Journal of Hematology & Oncology, 2021 Ubiquitin-conjugating enzyme E2 M (UBE2M) and ubiquitin-conjugating enzyme E2 F (UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part in posttranslational modification and change the activity of target proteins.
Yi-Chao Zheng +6 more
doaj +1 more source
International Journal of Molecular Sciences, 2020 Owing to a sessile lifestyle in nature, plants are routinely faced with diverse hostile environments such as various abiotic and biotic stresses, which lead to accumulation of free radicals in cells, cell damage, protein denaturation, etc., causing ...
Weigang Liu +8 more
semanticscholar +1 more source
The ubiquitin-proteasome system is required for African swine fever replication. [PDF]
PLoS ONE, 2017 Several viruses manipulate the ubiquitin-proteasome system (UPS) to initiate a productive infection. Determined viral proteins are able to change the host's ubiquitin machinery and some viruses even encode their own ubiquitinating or deubiquitinating ...
Lucía Barrado-Gil +4 more
doaj +1 more source
Communications Biology, 2020 Histones modulate gene expression by chromatin compaction, regulating numerous processes such as differentiation. However, the mechanisms underlying histone degradation remain elusive.
A. Fatima +12 more
semanticscholar +1 more source
Frontiers in Marine Science, 2022 Ubiquitination is an essential post-translational modification of proteins and involved in many physiological processes, including sperm differentiation, oocyte maturation, and embryonic development.
Kunhuang Han +7 more
doaj +1 more source
PLoS Pathogens, 2020 Senecavirus A (SVA), discovered in 2002, is an emerging pathogen of swine that has since been reported in numerous pork producing countries. To date, the mechanism of SVA replication remains poorly understood.
Liang Li +5 more
semanticscholar +1 more source
EMBO Journal, 2021 The assembly of a specific polymeric ubiquitin chain on a target protein is a key event in the regulation of numerous cellular processes. Yet, the mechanisms that govern the selective synthesis of particular polyubiquitin signals remain enigmatic.
Lukas Pluska +11 more
semanticscholar +1 more source
Expression Profiling of WSSV ORF 199 and Shrimp Ubiquitin Conjugating Enzyme in WSSV Infected [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 White spot syndrome virus (WSSV) is one of the major viral pathogens affecting shrimp aquaculture. Four proteins, WSSV199, WSSV 222, WSSV 249 and WSSV 403, from WSSV are predicted to encode a RING-H2 domain, which in presence of ubiquitin conjugating ...
K. Jeena +3 more
doaj +1 more source