Results 11 to 20 of about 27,627 (205)

Mechanism and Disease Association With a Ubiquitin Conjugating E2 Enzyme: UBE2L3 [PDF]

Frontiers in Immunology, 2022
Ubiquitin conjugating enzyme E2 is an important component of the post-translational protein ubiquitination pathway, which mediates the transfer of activated ubiquitin to substrate proteins. UBE2L3, also called UBcH7, is one of many E2 ubiquitin conjugating enzymes that participate in the ubiquitination of many substrate proteins and regulate many ...
Xiaoxia Zhang, Xiaoxia Zhang, Chengdong Huo, Chengdong Huo, Yating Liu, Ruiliang Su, Yang Zhao, Yumin Li   +7 more
openaire   +4 more sources

Conformational Dynamics Modulate Activation of the Ubiquitin Conjugating Enzyme Ube2g2 [PDF]

ACS Omega, 2017
The ubiquitin conjugating enzyme Ube2g2 together with its cognate E3 ligase gp78 catalyzes the synthesis of lysine-48 polyubiquitin chains constituting signals for the proteasomal degradation of misfolded proteins in the endoplasmic reticulum. Here, we employ NMR spectroscopy in combination with single-turnover diubiquitin formation assays to examine ...
Pearl Magala, William E. Bocik, Ananya Majumdar, Joel R. Tolman   +3 more
openaire   +4 more sources

Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c

Acta Pharmaceutica Sinica B, 2017
UbcH5c belongs to the ubiquitin-conjugating enzyme family and plays an important role in catalyzing ubiquitination during TNF-α--triggered NF-κB activation. Therefore, UbcH5c is a potent therapeutic target for the treatment of inflammatory and autoimmune diseases induced by aberrant activation of NF-κB. In this study, we established a stable expression
Honglin Li, Junsheng Zhu, Fangshu Wu, Lili Zhu   +3 more
openaire   +4 more sources

Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence

Redox Biology, 2018
Cellular senescence plays essential roles in tissue homeostasis as well as a host of diseases ranging from cancers to age-related neurodegeneration. Various molecular pathways can induce senescence and these different pathways dictate the phenotypic and metabolic changes that accompany the transition to, and maintenance of, the senescence state.
Kendra S. Plafker, Katarzyna Zyla, William Berry, Scott M. Plafker   +3 more
openaire   +5 more sources

Unraveling the Role of Ubiquitin-Conjugating Enzyme UBE2T in Tumorigenesis: A Comprehensive Review. [PDF]

Cells
Ubiquitin-conjugating enzyme E2 T (UBE2T) is a crucial E2 enzyme in the ubiquitin-proteasome system (UPS), playing a significant role in the ubiquitination of proteins and influencing a wide range of cellular processes, including proliferation ...
Gao C, Liu YJ, Yu J, Wang R, Shi JJ, Chen RY, Yang GJ, Chen J.   +7 more
europepmc   +2 more sources

The Ubiquitin Conjugating Enzyme UbcD1 is Required for Notch Signaling Activation During Drosophila Wing Development. [PDF]

Front Genet, 2021
Notch signaling pathway plays crucial roles in animal development. Protein ubiquitination contributes to Notch signaling regulation by governing the stability and activity of major signaling components.
Zhang F, Chen Y, Shen J, Zhang J.
europepmc   +2 more sources

Targeting neddylation E2s: a novel therapeutic strategy in cancer

Journal of Hematology & Oncology, 2021
Ubiquitin-conjugating enzyme E2 M (UBE2M) and ubiquitin-conjugating enzyme E2 F (UBE2F) are the two NEDD8-conjugating enzymes of the neddylation pathway that take part in posttranslational modification and change the activity of target proteins.
Yi-Chao Zheng, Yan-Jia Guo, Bo Wang, Chong Wang, M. A. A. Mamun, Ya Gao, Hong-Min Liu   +6 more
doaj   +1 more source

Molecular Characteristics of Scylla paramamosain Ubiquitin-Conjugating Enzyme E2 and Expression Analysis During Oogenesis

Frontiers in Marine Science, 2022
Ubiquitination is an essential post-translational modification of proteins and involved in many physiological processes, including sperm differentiation, oocyte maturation, and embryonic development.
Kunhuang Han, Kunhuang Han, Yanbin Dai, Yanbin Dai, Ziping Zhang, Congwen Rao, Li Zhou, Yilei Wang   +7 more
doaj   +1 more source

The ubiquitin-proteasome system is required for African swine fever replication. [PDF]

PLoS ONE, 2017
Several viruses manipulate the ubiquitin-proteasome system (UPS) to initiate a productive infection. Determined viral proteins are able to change the host's ubiquitin machinery and some viruses even encode their own ubiquitinating or deubiquitinating ...
Lucía Barrado-Gil, Inmaculada Galindo, Diego Martínez-Alonso, Sergio Viedma, Covadonga Alonso   +4 more
doaj   +1 more source

Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3. [PDF]

MedComm (2020)
Periodontitis is a chronic periodontal inflammatory disease caused by periodontal pathogens commonly seen in adults. Eupalinolide B (EB) is a sesquiterpenoid natural product extracted from Eupatorium lindleyanum and has been reported as a potential drug ...
Kuang W, Zhuge R, Song P, Yi L, Zhang S, Zhang Y, Wong YK, Chen R, Zhang J, Wang Y, Liu D, Gong Z, Wang P, Ouyang X, Wang J.   +14 more
europepmc   +2 more sources