Results 191 to 200 of about 30,210 (297)

Initial Characterization of a Conserved Active Site Residue for the Cdc34 Ubiquitin Conjugating Enzyme

, 2014
Arvin Akoopie
openalex   +1 more source

Redirecting the specificity of ubiquitination by modifying ubiquitin-conjugating enzymes.

, 1995
Mark Gosink, Richard D. Vierstra
openalex   +2 more sources

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network [PDF]

, 2009
Gabriel Markson, Christina Kiel, Russell Hyde, Stephanie E. Brown, Panagoula Charalabous, Anja Bremm, Jennifer I. Semple, Jonathan Woodsmith, Simon Duley, Kourosh Salehi‐Ashtiani, Marc Vidal, David Komander, Luís Serrano, Paul J. Lehner, Christopher M. Sanderson   +14 more
openalex   +1 more source

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Genome-wide identification of wheat Ubiquitin-conjugating enzyme gene family and its role in wheat powdery mildew disease resistance. [PDF]

BMC Plant Biol
Hu P, Zhang L, Xu J, Ren Y, Wang M, Luo W, Zhou K, Zhu X, Liu Z, Hu H, Li C.   +10 more
europepmc   +1 more source

Upregulation of ubiquitin-conjugating enzyme E2T (UBE2T) predicts poor prognosis and promotes hepatocellular carcinoma progression. [PDF]

Bioengineered, 2021
Ren X, Li A, Ying E, Fang J, Li M, Yu J.
europepmc   +1 more source

Hepatitis C Virus Downregulates Ubiquitin-Conjugating Enzyme E2S Expression To Prevent Proteasomal Degradation of NS5A, Leading to Host Cells More Sensitive to DNA Damage [PDF]

, 2018
Hang Pham, Tram Nguyen, Lap P. Nguyen, Sang‐Seop Han, Yun-Sook Lim, Soon B. Hwang   +5 more
openalex   +1 more source

Bioorthogonal Sonodynamic Plug‐and‐Play Targeting Chimeras (SDPTAC) for Precise Targeted Protein Degradation

Advanced Science, EarlyView.
Bioorthogonal SDPTAC harnesses US‐responsive Ce6‐TCO and Tz ligands via IEDDA click chemistry to assemble degraders in situ, generating ROS that selectively eliminate nuclear, cytosolic, and membrane proteins, thereby suppressing deep‐seated tumors in vivo.
Yuhan Bao, Yaojin Zhu, Xinhao Wei, Yuxin Fang, Jiayi Zhu, Fei Gao, Guoqiang Dong, Shipeng He, Chunquan Sheng   +8 more
wiley   +1 more source

StUBC13, a Ubiquitin-Conjugating Enzyme, Positively Regulates Salt and Osmotic Stresses in Potato. [PDF]

Int J Mol Sci
Fu X, Tang X, Zhang N, Si H.
europepmc   +1 more source

Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis. [PDF]

Mol Cancer, 2022
Qi S, Guan X, Zhang J, Yu D, Yu X, Li Q, Yin W, Cheng XD, Zhang W, Qin JJ.   +9 more
europepmc   +1 more source