Results 191 to 200 of about 27,627 (205)

Molecular Basis of Lys-63-linked Polyubiquitination Inhibition by the Interaction between Human Deubiquitinating Enzyme OTUB1 and Ubiquitin-conjugating Enzyme UBC13

, 2012
Yusuke Sato, Atsushi Yamagata, Sakurako Goto‐Ito, Keiko Kubota, Rikako Miyamoto, Shinichiro Nakada, Shuya Fukai   +6 more
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Ubiquitin-conjugating enzyme genes in Oesophagostomum dentatum

Parasitology Research, 2006
Full-length genes representing different isoforms of the ubiquitin-conjugating enzyme UBC-2 were isolated from Oesophagostomum dentatum, cloned and sequenced. The alignment of their sequences (designated Od-ubc-2.1 to Od-ubc-2.3) revealed nucleotide variation at three positions within the predicted open reading frame of 444 bp.
Alasdair J. Nisbet, Youssef G. Abs EL-Osta, Pauline A. Cottee, Robin B. Gasser   +3 more
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Conformational Flexibility of a Ubiquitin Conjugation Enzyme (E2)

Biochemistry, 1999
Ubiquitination plays important roles in a variety of biological processes, such as DNA repair, cell cycle regulation, and p53-dependent processes. Despite intensive studies in ubiquitination, the mechanism of substrate recognition is still not well understood.
Binghui Shen, David J. Chen, Yuan Chen, Yate Ching Yuan, Qin Liu, Qin Liu   +5 more
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Ubiquitin-conjugating enzyme E2C: A potential cancer biomarker

The International Journal of Biochemistry & Cell Biology, 2014
The ubiquitin-conjugating enzymes 2C (UBE2C) is an integral component of the ubiquitin proteasome system. UBE2C consists of a conserved core domain containing the catalytic Cys residue and an N-terminal extension. The core domain is required for ubiquitin adduct formation by interacting with the ubiquitin-fold domain in the E1 enzyme, and contributes ...
Qihan Dong, Qihan Dong, Mu Yao, Chanlu Xie, Jianmin Wu, Christopher J. Powell   +5 more
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Characterization of the mouse ubiquitin-conjugating enzyme gene UbcM4

Mammalian Genome, 1999
The ubiquitination pathway targets not only normal (short-lived) intracellular eukaryotic proteins for degradation when appropriate, but also serves to eliminate mutant/misfolded proteins from the cell. An understanding of the molecular basis of the interaction between the ubiquitin-conjugating enzymes (E2s), ubiquitin protein ligases (E3s), and target
Stephen A. Rose, Philip A. Robinson, Helen C. Ardley, Ulrike Nuber, Alexander F. Markham, Martin Scheffner, Terry P. Moynihan   +6 more
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QRI8, a novel ubiquitin-conjugating enzyme in Saccharomyces cerevisiae

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1992
We have cloned and sequenced the gene encoding a novel ubiquitin-conjugating enzyme in Saccharomyces cerevisiae. Disruption of this gene shows that it is not essential for cell viability.
Estelle Decoster, Gérard Faye, Anne Vassal, Annick Boulet   +3 more
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Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3

Mammalian Genome, 1996
Ubiquitin-conjugating enzymes (E2s) are essential components of the post-translational protein ubiquitination pathway, mediating the transfer of activated ubiquitin to substrate proteins. We have identified a human gene, UBE2L3, localized on Chromosome (Chr) 22q11.
J. P. Leek, Philip A. Robinson, T. P. Moynihan, N. S. Brindle, J. Thompson, Alex F. Markham, H. C. Ardley   +6 more
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Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells

Trends in Biochemical Sciences, 1990
Covalent attachment of ubiquitin to cellular proteins is essential for cell viability and is catalysed by a set of distinct ubiquitin-conjugating enzymes. Individual members of this novel enzyme family mediate strikingly diverse functions, including DNA repair, cell cycle control, selective protein degradation and essential functions of the stress ...
Stefan Jentsch, Wolfgang Seufert, Hans-Albert Reins, Thomas Sommer   +3 more
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Location of ubiquitin conjugates and ubiquitin-conjugating enzymes in rabbit brain.

1991
The work reports the location of ubiquitin conjugates and ubiquitin-conjugating enzymes in homogenates of rabbit brain.
MAGNANI, MAURO, SERAFINI, GIORDANO, ANTONELLI, ANTONELLA, CRINELLI, RITA, Manuela Malatesta, Giancarlo Gazzanelli   +5 more
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BRUCE—a giant death-defying ubiquitin-conjugating enzyme

Trends in Cell Biology, 1998
Abstract HAUSER, H-P., BARDROFF, M., PYROWOLAKIS, G. and JENTSCH, S. (1998) A giant ubiquitin-conjugating enzyme related to IAP apoptosis inhibitors J. Cell Biol.
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