Results 21 to 30 of about 30,210 (297)
Ubiquitin in Motion: Structural Studies of the Ubiquitin-Conjugating Enzyme∼Ubiquitin Conjugate [PDF]
Biochemistry, 2011 Ubiquitination of proteins provides a powerful and versatile post-translational signal in the eukaryotic cell. The formation of a thioester bond between ubiquitin (Ub) and the active site of a ubiquitin-conjugating enzyme (E2) is critical for the transfer of Ub to substrates. Assembly of a functional ubiquitin ligase (E3) complex poised for Ub transfer
Jonathan N, Pruneda +4 more
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The ubiquitin-proteasome system is required for African swine fever replication. [PDF]
PLoS ONE, 2017 Several viruses manipulate the ubiquitin-proteasome system (UPS) to initiate a productive infection. Determined viral proteins are able to change the host's ubiquitin machinery and some viruses even encode their own ubiquitinating or deubiquitinating ...
Lucía Barrado-Gil +4 more
doaj +1 more source
Frontiers in Marine Science, 2022 Ubiquitination is an essential post-translational modification of proteins and involved in many physiological processes, including sperm differentiation, oocyte maturation, and embryonic development.
Kunhuang Han +7 more
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Expression Profiling of WSSV ORF 199 and Shrimp Ubiquitin Conjugating Enzyme in WSSV Infected [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 White spot syndrome virus (WSSV) is one of the major viral pathogens affecting shrimp aquaculture. Four proteins, WSSV199, WSSV 222, WSSV 249 and WSSV 403, from WSSV are predicted to encode a RING-H2 domain, which in presence of ubiquitin conjugating ...
K. Jeena +3 more
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UBE2C (ubiquitin-conjugating enzyme E2C) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on UBE2C (ubiquitin-conjugating enzyme E2C), with data on DNA, on the protein encoded, and where the gene is implicated.
Pallate, P, Berlingieri, MT, Fusco, A
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Structural Diversity of Ubiquitin E3 Ligase
Molecules, 2021 The post-translational modification of proteins regulates many biological processes. Their dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications that target lysine residue and regulate many cellular processes ...
Sachiko Toma-Fukai, Toshiyuki Shimizu
doaj +1 more source
Scientific Reports, 2021 The inducible Di-Cre system was used to delete the putative ubiquitin-conjugating enzyme 13 gene (ubc13) of Plasmodium falciparum to study its role in ubiquitylation and the functional consequence during the parasite asexual blood stage.
Supawadee Maneekesorn +6 more
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Mechanism and Disease Association With a Ubiquitin Conjugating E2 Enzyme: UBE2L3
Frontiers in Immunology, 2022 Ubiquitin conjugating enzyme E2 is an important component of the post-translational protein ubiquitination pathway, which mediates the transfer of activated ubiquitin to substrate proteins.
Xiaoxia Zhang +7 more
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Creation of a Pluripotent Ubiquitin-Conjugating Enzyme [PDF]
Molecular and Cellular Biology, 2001 We describe the creation of a pluripotent ubiquitin-conjugating enzyme (E2) generated through a single amino acid substitution within the catalytic domain of RAD6 (UBC2). This RAD6 derivative carries out the stress-related function of UBC4 and the cell cycle function of CDC34 while maintaining its own DNA repair function.
C, Ptak +5 more
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NEDD8-conjugating enzyme E2s: critical targets for cancer therapy
Cell Death Discovery, 2023 NEDD8-conjugating enzymes, E2s, include the well-studied ubiquitin-conjugating enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F (UBE2F).
Lisha Zhou +7 more
doaj +1 more source