Results 21 to 30 of about 91,279 (227)
Scientific Reports, 2021 The inducible Di-Cre system was used to delete the putative ubiquitin-conjugating enzyme 13 gene (ubc13) of Plasmodium falciparum to study its role in ubiquitylation and the functional consequence during the parasite asexual blood stage.
Supawadee Maneekesorn +6 more
doaj +1 more source
Structural Diversity of Ubiquitin E3 Ligase
Molecules, 2021 The post-translational modification of proteins regulates many biological processes. Their dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications that target lysine residue and regulate many cellular processes ...
Sachiko Toma-Fukai, Toshiyuki Shimizu
doaj +1 more source
Ubiquitin-Conjugating Enzyme E2 D2
Definitions, 2020 Ubiquitin-conjugating enzyme E2 D2 (147 aa, ~17 kDa) is encoded by the human UBE2D2 gene. This protein is involved in the covalent attachment of ubiquitin to protein substrates.
semanticscholar +1 more source
Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2 [PDF]
, 1995 UbcH2 encodes a human ubiquitin conjugating enzyme (E2) able to conjugate ubiquitin to histone H2A in an E3 independent manner in vitro, which indicates that UbcH2 directly interacts with its substrates.
Kaiser, Peter +3 more
core +1 more source
Characterization of a Dominant Negative Mutant of the Cell Cycle Ubiquitin-conjugating Enzyme Cdc34 [PDF]
, 1995 The yeast Saccharomyces cerevisiae CDC34 gene encodes a ubiquitin-conjugating enzyme that is required for the cell cycle G(1)/S transition. We show here that a dominant negative Cdc34 protein is generated by simultaneously replacing both Cys and Leu with
Banerjee, Amit +2 more
core +2 more sources
NEDD8-conjugating enzyme E2s: critical targets for cancer therapy
Cell Death Discovery, 2023 NEDD8-conjugating enzymes, E2s, include the well-studied ubiquitin-conjugating enzyme E2 M (UBE2M) and the poorly characterized ubiquitin-conjugating enzyme E2 F (UBE2F).
Lisha Zhou +7 more
doaj +1 more source
Dynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge network [PDF]
, 2012 Ubiquitination relies on a subtle balance between selectivity and promiscuity achieved through specific interactions between ubiquitin-conjugating enzymes (E2s) and ubiquitin ligases (E3s).
Bonvin, Alexandre M. J. J. +4 more
core +3 more sources
Ubiquitin-Conjugating Enzyme Gene
Definitions, 2020 Genes encoding enzymes that catalyze the second step in the ubiquitination reaction via the transfer of ubiquitin from E1 ubiquitin-activating enzymes to themselves.
semanticscholar +1 more source
E3-ubiquitin ligases and recent progress in osteoimmunology
Frontiers in Immunology, 2023 Ubiquitin-mediated proteasomal degradation is a post-transcriptional protein modification that is comprised of various components including the 76-amino acid protein ubiquitin (Ub), Ub-activating enzyme (E1), Ub-conjugating enzyme (E2), ubiquitin ligase (
Yosuke Asano +8 more
doaj +1 more source
SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication. [PDF]
, 2016 Accumulating evidence suggests that viruses hijack cellular proteins to circumvent the host immune system. Ubiquitination and SUMOylation are extensively studied posttranslational modifications (PTMs) that play critical roles in diverse biological ...
Gong, P +9 more
core +1 more source