UBE2C (ubiquitin-conjugating enzyme E2C) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on UBE2C (ubiquitin-conjugating enzyme E2C), with data on DNA, on the protein encoded, and where the gene is implicated.
Pallate, P, Berlingieri, MT, Fusco, A
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Expression Profiling of WSSV ORF 199 and Shrimp Ubiquitin Conjugating Enzyme in WSSV Infected [PDF]
Asian-Australasian Journal of Animal Sciences, 2012 White spot syndrome virus (WSSV) is one of the major viral pathogens affecting shrimp aquaculture. Four proteins, WSSV199, WSSV 222, WSSV 249 and WSSV 403, from WSSV are predicted to encode a RING-H2 domain, which in presence of ubiquitin conjugating ...
K. Jeena +3 more
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miR-379-5p affects breast cancer cell behavior by targeting UBE2E3 ubiquitin conjugating enzyme. [PDF]
PLoS OneMicroRNAs (miRNAs) play an increasingly recognized role in modulating cancer development. Due to their function in regulating gene expression, miRNAs can suppress or promote tumorigenesis. miR-379-5p expression is downregulated in multiple human cancers,
Schroder AK +5 more
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Phoresis and Enhanced Diffusion Compete in Enzyme Chemotaxis [PDF]
Nano Lett. 2018, 18, 4, 2711-2717, 2021 Chemotaxis of enzymes in response to gradients in the concentration of their substrate has been widely reported in recent experiments, but a basic understanding of the process is still lacking. Here, we develop a microscopic theory for chemotaxis, valid for enzymes and other small molecules.
arxiv +1 more source
Scientific Reports, 2021 The inducible Di-Cre system was used to delete the putative ubiquitin-conjugating enzyme 13 gene (ubc13) of Plasmodium falciparum to study its role in ubiquitylation and the functional consequence during the parasite asexual blood stage.
Supawadee Maneekesorn +6 more
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Structural Diversity of Ubiquitin E3 Ligase
Molecules, 2021 The post-translational modification of proteins regulates many biological processes. Their dysfunction relates to diseases. Ubiquitination is one of the post-translational modifications that target lysine residue and regulate many cellular processes ...
Sachiko Toma-Fukai, Toshiyuki Shimizu
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Targeting CDC34 E2 ubiquitin conjugating enzyme for lung cancer therapy. [PDF]
EBioMedicine, 2020 Zhang S, Sun Y.
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Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination [PDF]
Structure, 2019 Ubiquitin-conjugating enzymes (E2s) govern key aspects of ubiquitin signaling. Emerging evidence suggests that the activities of E2s are modulated by posttranslational modifications; the structural underpinnings, however, are largely unclear. Here, we unravel the structural basis and mechanistic consequences of a conserved autoubiquitination event near
Henning Urlaub +12 more
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Ubiquitin conjugating enzymes participate in polyglutamine protein aggregation [PDF]
BMC Cell Biology, 2007 Abstract Background Protein aggregation is a hallmark of several neurodegenerative diseases including Huntington's disease and Parkinson's disease. Proteins containing long, homopolymeric stretches of glutamine are especially prone to form aggregates.
Lynn Boyd +7 more
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Ubiquitin-conjugating enzyme E2T promotes tumor stem cell characteristics and migration of cervical cancer cells by regulating the GRP78/FAK pathway. [PDF]
Open Life Sci, 2021 Ubiquitin-conjugating enzyme E2T (UBE2T) functions as an E2 ubiquitin-conjugating enzyme in the ubiquitin-proteasome degradation system and mediates cellular processes, such as cell cycle, proliferation, and differentiation.
Liu Y, Ji W, Yue N, Zhou W.
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