Results 311 to 320 of about 91,428 (363)

Dihydrotanshinone I Targets PGAM1 to Induce SYVN1‐Mediated Ubiquitination and Suppress Glycolysis in Hepatocellular Carcinoma

Phytotherapy Research, EarlyView.
DHT Induced SYVN1‐Mediated PGAM1 Degradation Blocks HCC Glycolysis. ABSTRACT Phosphoglycerate mutase 1 (PGAM1) is a glycolytic enzyme frequently overexpressed in hepatocellular carcinoma (HCC), contributing to tumor progression through aberrant glycolysis.
Ru Xu, Jiawei Dai, Ruijie Gong, Ruoxin Tu, Qiaozi Wang, Hongdan Zheng, Li Zhou, Shusheng Wang, Jiabin Cai, Haixiang Sun, Pingting Gao, Pengfei Gao   +11 more
wiley   +1 more source

Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases: a mendelian randomization analysis. [PDF]

Arch Dermatol Res
Wang X, Zhu Z.
europepmc   +1 more source

Nanozymes in Reactive Oxygen Species‐Dependent Diseases: From Design and Preclinical Studies to Clinical Translation Prospects

Small Structures, EarlyView.
Nanozymes emerge as promising therapeutic agents for reactive oxygen species (ROS)‐dependent diseases, offering advantages over traditional biocatalysts through enhanced stability, tunability, and targeting capabilities. This review explores their mechanisms, design strategies, and clinical progress, emphasizing precision medicine potential.
Lihong Zhou, Jingyu Yan, Chenying Cui, Yurong Xu, Kaifang Zhang, Meijun Du, Zhuowei Zhang, Xiuping Wu, Bing Li   +8 more
wiley   +1 more source

UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance. [PDF]

Oncogene
Rodriguez Tirado C, Wang C, Li X, Deng S, Gonzalez J, Johnson NA, Xu Y, Metang LA, Sundar Rajan M, Yang Y, Yin Y, Hofstad M, Raj GV, Zhang S, Lemoff A, He W, Fan J, Wang Y, Wang T, Mu P.   +19 more
europepmc   +1 more source

Expression of ubiquitin-conjugating enzyme E2T in colorectal cancers and clinical implications. [PDF]

Oncol Lett, 2020
Wu X, Liu G, Liu R, He J, Wang G, Zhang H, Liu T, Bai J, Cheng N, Qiu J.   +9 more
europepmc   +1 more source

Cooperative Function of Atg8‐ and TORC1‐Mediated Activities in Yeast

Yeast, EarlyView.
The atg8Δ mutant is sensitive to rapamycin, and both lipidation‐dependent and ‐independent functions of Atg8 are necessary for survival during impaired TORC1 activity. Atg8‐ and TORC1‐mediated functions may contribute to maintaining vacuolar functions.
Yumiko Oba, Miyuki Higuchi, Naoka Takahashi, Haruko Katsuta, Naoki Koike, Takashi Ushimaru, Yoko Kimura   +6 more
wiley   +1 more source

A Novel Confocal Scanning Protein-Protein Interaction Assay (PPI-CONA) Reveals Exceptional Selectivity and Specificity of CC0651, a Small Molecule Binding Enhancer of the Weak Interaction between the E2 Ubiquitin-Conjugating Enzyme CDC34A and Ubiquitin. [PDF]

Bioconjug Chem
Koszela J, Pham NT, Shave S, St-Cyr D, Ceccarelli DF, Orlicky S, Marinier A, Sicheri F, Tyers M, Auer M.   +9 more
europepmc   +1 more source

Role of NRP1/HDAC4/CREB/RIPK1 Axis in SARS‐CoV2 S1 Spike Subunit‐Induced Neuronal Toxicity

FASEB BioAdvances, EarlyView.
Extracellular SARS‐CoV2 Spike‐S1 protein via NRP1 internalizes in the cytosol of SH‐SY5Y cells. Once inside, it upregulates the epigenetic eraser HDAC4, which binds transcriptional factor CREB, causes RIPK1 up‐regulation, and therefore necroptotic cell death.
Luca Sanguigno, Natascia Guida, Mariarosaria Cammarota, Silvia Ruggiero, Angelo Serani, Francesca Galasso, Vincenzo Pizzorusso, Francesca Boscia, Luigi Formisano   +8 more
wiley   +1 more source

Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle

FASEB BioAdvances, EarlyView.
Current model on the effects of acute endurance exercise on the AS regulatory mechanism with key trans‐factors/RBPs (e.g., hnRNP‐A1, ‐A3, and TIA1). ABSTRACT Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome.
Alexander Ahn, Jeongjin J. Kim, Aaron L. Slusher, Jeffrey Y. Ying, Eric Y. Zhang, Andrew T. Ludlow   +5 more
wiley   +1 more source

Cdc34p Ubiquitin-Conjugating Enzyme Is a Component of the Tombusvirus Replicase Complex and Ubiquitinates p33 Replication Protein

, 2008
Zhenghe Li, Daniel Barajas, Tadas Panavas, D. Herbst, Peter D. Nagy   +4 more
openalex   +1 more source