A Ubiquitin-Conjugating Enzyme Is Essential for Developmental Transitions inDictyostelium [PDF]
Molecular Biology of the Cell, 1997 We have identified a developmentally essential gene,UbcB, by insertional mutagenesis. The encoded protein (UBC1) shows very high amino acid sequence identity to ubiquitin-conjugating enzymes from other organisms, suggesting that UBC1 is involved in protein ubiquitination and possibly degradation during Dictyostelium development.
Anson Nomura +3 more
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A human ubiquitin-conjugating enzyme homologous to yeast UBC8.
Journal of Biological Chemistry, 1994 Ubiquitin-conjugating enzymes catalyze the covalent attachment of ubiquitin to cellular substrates. Here we describe the isolation of a novel ubiquitin-conjugating enzyme from human placenta and the cloning of the corresponding cDNA. DNA sequencing revealed that this gene, UbcH2, encodes a protein with significant sequence similarity to yeast UBC8.
Peter K. Kaiser +8 more
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Three-dimensional structure of a ubiquitin-conjugating enzyme (E2).
Journal of Biological Chemistry, 1992 The x-ray crystal structure of a recombinant ubiquitin-conjugating enzyme (E2) encoded by the UBC1 gene of the plant Arabidopsis thaliana has been determined with the use of multiple isomorphous replacement techniques and refined at 2.4-A resolution by simulated annealing and restrained least-squares.
R.D. Vierstra +3 more
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Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c
Acta Pharmaceutica Sinica B, 2017 UbcH5c belongs to the ubiquitin-conjugating enzyme family and plays an important role in catalyzing ubiquitination during TNF-α--triggered NF-κB activation. Therefore, UbcH5c is a potent therapeutic target for the treatment of inflammatory and autoimmune diseases induced by aberrant activation of NF-κB. In this study, we established a stable expression
Honglin Li +3 more
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Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence
Redox Biology, 2018 Cellular senescence plays essential roles in tissue homeostasis as well as a host of diseases ranging from cancers to age-related neurodegeneration. Various molecular pathways can induce senescence and these different pathways dictate the phenotypic and metabolic changes that accompany the transition to, and maintenance of, the senescence state.
Kendra S. Plafker +3 more
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IL-1β turnover by the UBE2L3 ubiquitin conjugating enzyme and HECT E3 ligases limits inflammation. [PDF]
Nat Commun, 2023 Mishra V +13 more
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Rice ubiquitin-conjugating enzyme OsUbc13 negatively regulates immunity against pathogens by enhancing the activity of OsSnRK1a. [PDF]
Plant Biotechnol J, 2023 Liu J +6 more
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Ubiquitin-Conjugating Enzyme OsUBC11 Affects the Development of Roots via Auxin Pathway. [PDF]
Rice (N Y), 2023 Han Y +10 more
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Overexpression of Ubiquitin-Conjugating Enzyme E2C Is Associated with Worsened Prognosis in Prostate Cancer. [PDF]
Int J Mol Sci, 2022 Wu X +6 more
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Genome-wide characterization of ubiquitin-conjugating enzyme gene family explores its genetic effects on the oil content and yield of Brassica napus. [PDF]
Front Plant Sci, 2023 Yao S +8 more
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